成果

創薬等先端技術支援基盤プラットフォーム(BINDS)の支援実施者による支援技術に関する研究成果と、BINDSの支援を受けた外部研究者の研究成果(論文)を紹介しています。

開発されたデータベースやツール

ケミカルシーズ・リード 探索ユニット

インシリコユニット

プラットフォーム機能最適化ユニット

BINDS支援技術に関する研究成果(論文)

BINDSの支援を受けた研究成果(論文)

TakashiKatayama, ShintaroKinugawa, ShingoTakada, TakaakiFurihata, ArataFukushima, TakashiYokota, ToshihisaAnzai, MitsueHibino, HideyoshiHarashima, YumaYamada (2019)  A mitochondrial delivery system using liposome-based nanocarriers that target myoblast cells Science Direct. :in press,  DOI:https://doi.org/10.1016/j.mito.2019.07.005
Takahiro Jomori, Yasumasa Hara, Miho Sasaoka, Kazuo Harada, Andi Setiawan, Kazumasa Hirata, Atsushi Kimishima, Masayoshi Arai (2019)  Mycobacterium smegmatis alters the production of secondary metabolites by marine-derived Aspergillus niger Journal of Natural Medicines . :18,  1-7 DOI:https://doi.org/10.1007/s11418-019-01345-0
NaohiroKatagiri, SatoruNagatoishi, KouheiTsumoto, HideyaEndo (2019)  Structural features of methionine aminopeptidase2-active corepeptide essential for binding with S100A4 Biochemical and Biophysical Research Communications. :in press,  DOI:https://doi.org/10.1016/j.bbrc.2019.07.006
HiroyukiMiyachi, TomohiroYuzuriha, RyotaroTabata, SyoheiFukuda, KazutoNunomura, BangzhongLin, TadayukiKobayashi, KenjiIshimoto, TakefumiDoi, KeisukeTachibana (2019)  Structural development of 1H-pyrazolo-[3,4-b]pyridine-4-carboxylic acid derivatives as human peroxisome proliferator-activated receptor alpha (PPARα)-selective agonists Bioorganic & Medicinal Chemistry Letters. :in press,  DOI:https://doi.org/10.1016/j.bmcl.2019.06.062
Dimitri Schritt, Songling Li, John Rozewicki, Kazutaka Katoh, Kazuo Yamashita, Wayne Volkmuth, Guy Cavetc and Daron M. Standley (2019)  Repertoire Builder: high-throughput structural modeling of B and T cell receptors Royal Society of Chemistry. DOI:DOI: 10.1039/c9me00020h
Masaya Mori , Yuuta Fujikawa , Manami Kikkawa , Moeho Shino , Mei Sawane , Shiho Sato and Hideshi Inoue (2019)  A highly selective fluorogenic substrate for imaging glutathione Stransferase P1: development, and cellular applicability to epigenetic studies Chem. Comm.. DOI:DOI: 10.1039/x0xx00000x
Masayoshi Arai (2019)  Exploring Bioactive Marine Natural Products and Identification of Their Molecular Targets Springer. 291-303 DOI:https://doi.org/10.1007/978-981-13-6244-6_12
Suguru Yoshida,Takamitsu Hosoya  (2019)  Target Identification of Bioactive Compounds by Photoaffinity Labeling Using Diazido Probes Springer. 335-355 DOI:https://doi.org/10.1007/978-981-13-6244-6_14
Hiromichi Tanaka ,Hideyuki Konishi , Kei Manabe  (2019)  Palladium-Catalyzed One-Step Synthesis of Symmetrical Diaryl Sulfones from Aryl Halides and a Sulfur Dioxide Surrogate The Chemical Society of Japan. DOI:https://doi.org/10.1246/cl.190300
T. Shimo, K.Tachibana, Y. Kawawaki, Y. Watahiki, T. Ishigaki, Y. Nakatsuji, T. Hara, J. Kawakami ,S. Obika (2019)  Enhancement of exon skipping activity by reduction in secondary structure content of LNA-based splice-switching oligonucleotides ChemComm. 1-3 DOI:DOI: 10.1039/C8CC09648A
Jumpei Kondo , Masahiro Inoue  (2019)  Application of Cancer Organoid Model for Drug Screening and Personalized Therapy cells. 5 :8,  470-470 DOI:http://dx.doi.org/10.3390/cells8050470
Hidenori Hirai, Kyoko Matoba, Emiko Mihara, Takao Arimori , Junichi Takagi (2019)  Crystal structure of a mammalian Wnt–frizzled complex Nature Structural & Molecular Biologyvolume. :26,  372-379 DOI:https://doi.org/10.1038/s41594-019-0216-z
John Rozewicki, Songling Li, Karlou Mar Amada, Daron M. Standley, and Kazutaka Katoh (2019)  MAFFT-DASH: integrated protein sequence and structural alignment Nucleic Acids Research. 1 DOI:doi: 10.1093/nar/gkz342
Boonmin Poh, Hideto Koso, Hiroyuki Momota, Takashi Komori, Yutaka Suzuki, Nobuaki Yoshida, Yasushi Ino, Tomoki Todo, Sumiko Watanabe (2019)  Foxr2 promotes formation of CNS-embryonal tumors in a Trp53-deficient background Neuro-Oncology. noz067 1-28 DOI:https://doi.org/10.1093/neuonc/noz067
Daiki Hayashi, Ryosuke Tsumagari, Ke Liu, Shuji Ueda, Minoru Yamanoue,Fumio Sakane and Yasuhito Shirai (2019)  Screening of subtype-specific activators and inhibitors for diacylglycerol kinase The Journal of Biochemistry. 1-6 DOI:10.1093/jb/mvz008
Yosuke Sakata, Kosuke Yabunaka, Yuko Kobayashi, Hirohisa Omiya, Naoki Umezawa , Hye-Sook Kim, Yusuke Wataya, Yoshimi Tomita, Yosuke Hisamatsu, Nobuki Kato, Hirokazu Yagi, Tadashi Satoh, Koichi Kato¶, Haruto Ishikawa, and Tsunehiko Higuchi (2019)  Potent Antimalarial Activity of Two Arenes Linked with Triamine Designed To Have Multiple Interactions with Heme ACS Medicinal. Chemistry. Letters. 9 :10,  980-985 DOI:10.1021/acsmedchemlett.8b00222
Sebastian A. Andrei, Pim de Vink, Eline Sijbesma, Ling Han, Prof. Luc Brunsveld, Prof. Nobuo Kato, Prof. Christian Ottmann, Dr. Yusuke Higuchi (2019)  Rationally Designed Semisynthetic Natural Product Analogues for Stabilization of 14‐3‐3 Protein–Protein Interactions A Journal of the German Chemical Society. 57 :41,  13470-13474 DOI:10.1002/anie.201806584 PMID:30025189 
Akinobu Senoo, Satoru Nagatoishi, Anna Moberg, Linnea Nygren Babol, Tomoya Mitani, Takumi Tashima, Shota Kudo, Kouhei Tsumoto (2019)  Inhibition of homophilic dimerization and disruption of cell adhesion by P-cadherin-specific small molecules from SPR-based assays Chemical communications . 54 :42,  5350-5353 DOI: 10.1039/C8CC01964A
Taito Matsuda, Takashi Irie, Shutaro Katsurabayashi, Yoshinori Hayashi, Tatsuya Nagai, Nobuhiko Hamazaki, Aliya Mari D Adefuin, Fumihito Miura, Takashi Ito, Hiroshi Kimura, Katsuhiko Shirahige, Tadayuki Takeda, Katsunori Iwasaki, Takuya Imamura, Kinichi Nakashima (2019)  Pioneer factor NeuroD1 rearranges transcriptional and epigenetic profiles to execute microglia-neuron conversion. Neuron. 3 :101,  472-485 DOI:10.1016/j.neuron.2018.12.010. PMID:30638745