成果

創薬等先端技術支援基盤プラットフォーム(BINDS)の支援実施者による支援技術に関する研究成果と、BINDSの支援を受けた外部研究者の研究成果(論文)を紹介しています。

開発されたデータベースやツール

ケミカルシーズ・リード 探索ユニット

インシリコユニット

プラットフォーム機能最適化ユニット

BINDS支援技術に関する研究成果(論文)

Sakamoto M., Suzuki, H., Yura, K. (2019)  Relationship between conformation shift and disease related variation sites in ATP-binding cassette transporter proteins. Biophysics and Physicobiology. 16 68-79 DOI:doi: 10.2142/biophysico.16.0_68
Hiromitsu Araki, Fumihito Miura, Akira Watanabe, Chikako Morinaga, Fumiyo Kitaoka, Yuko Kitano, Noriko Sakai, Yumiko Shibata, Motoki Terada, So Goto, Shinya Yamanaka, Masayo Takahashi, Takashi Ito (2019)  Base-Resolution Methylome of Retinal Pigment Epithelial Cells Used in the First Trial of Human Induced Pluripotent Stem Cell-Based Autologous Transplantation. Stem Cell Reports. 13 :4,  761-774 DOI:10.1016/j.stemcr.2019.08.014 PMID:31564644 
Fumihito Miura, Yukiko Shibata, Miki Miura, Yuhei Sangatsuda, Osamu Hisano, Hiromitsu Araki, Takashi Ito (2019)  Highly efficient single-stranded DNA ligation technique improves low-input whole-genome bisulfite sequencing by post-bisulfite adaptor tagging. Nucleic Acids Research. 47 :15,  e85- DOI:10.1093/nar/gkz435 PMID:31114914 

BINDSの支援を受けた研究成果(論文)

Takayuki Kato , Fumiaki Makino , Takanori Nakane , Naoya Terahara , Takeshi Kaneko , Yuko Shimizu , Sohei Motoki , Isamu Ishikawa, Koji Yonekura, and Keiichi Namba (2020)  Structure of the native supercoiled flagellar hook as a universal joint Microsc. Microanal. 25 998-999 DOI: DOI: https://doi.org/10.1017/S1431927619005725
Takayuki Kato, Fumiaki Makino, Tomoko Miyata, Péter Horváth & Keiichi Namba  (2019)  Structure of the native supercoiled flagellar hook as a universal joint Nat. commun.. 10 DOI:https://doi.org/10.1038/s41467-019-13252-9
Yurika Yamada, Keiichi Namba & Takashi Fujii  (2020)  Cardiac muscle thin filament structures reveal calcium regulatory mechanism Nat. commun.. 11 DOI:https://doi.org/10.1038/s41467-019-14008-1
Hiroyuki Terashima,Chinatsu Tatsumi,Akihiro Kawamoto,Keiichi Namba,Tohru Minamino, andKatsumi Imada (2020)  In Vitro Autonomous Construction of the Flagellar Axial Structure in Inverted Membrane Vesicles Biomolecules. 10 :1,  DOI:https://doi.org/10.3390/biom10010126
Masahiro Hiraizumi, Keitaro Yamashita, Tomohiro Nishizawa, Osamu Nureki (2019)  Cryo-EM structures capture the transport cycle of the P4-ATPase flippase Science . 365 1149-1155 DOI:https://doi.org/10.1126/science.aay3353
Yuhei Araiso, Akihisa Tsutsumi, Jian Qiu, Kenichiro Imai, Takuya Shiota, Jiyao Song, Caroline Lindau, Lena-Sophie Wenz, Haruka Sakaue, Kaori Yunoki, Shin Kawano, Junko Suzuki, Marilena Wischnewski, Conny Schütze, Hirotaka Ariyama, Toshio Ando, Thomas Becker, Trevor Lithgow, Nils Wiedemann, Nikolaus Pfanner, Masahide Kikkawa & Toshiya Endo  (2019)  Structure of the mitochondrial import gate reveals distinct preprotein paths Nature. 575 395-401 DOI:https://doi.org/10.1038/s41586-019-1680-7
Jumpei Morimoto*Yasuhiro FukudaDaisuke KurodaTakumu WatanabeFumihiko YoshidaMizue AsadaToshikazu NakamuraAkinobu SenooSatoru NagatoishiKouhei TsumotoShinsuke Sando (2019)  A Peptoid with Extended Shape in Water J. Am. Chem. Soc.. 141 :37,  14612-14623 DOI:doi: 10.1021/jacs.9b04371
Kouhei Yoshida Satoru Nagatoishi Daisuke Kuroda Nanao Suzuki Takeshi Murata Kouhei Tsumoto (2019)  Phospholipid Membrane Fluidity Alters Ligand Binding Activity of a G Protein-Co biochemistry. 58 504-508 DOI:doi: 10.1021/acs.biochem.8b01194
Kazuhiro Nishiyama, Takuro Numaga‐Tomita, Yasuyuki Fujimoto, Tomohiro Tanaka, Chiemi Toyama, Akiyuki Nishimura, Tomohiro Yamashita, Naoya Matsunaga, Satoru Koyanagi, Yasu‐Taka Azuma, Yuko Ibuki, Koji Uchida, Shigehiro Ohdo, |Motohiro Nishida (2019)  Ibudilast attenuates doxorubicin‐induced cytotoxicity bysuppressing formation of TRPC3 channel and NADPH oxidase2 protein complexes Br J Pharmacol.. 176 3723-3738 DOI:doi: 10.1111/bph.14777
Takuya Yokoyama, Masaki Yukuhiro, Yuka Iwasaki, Chika Tanaka, Kazunari Sankoda, Risa Fujiwara, Atsushi Shibuta, Taishi Higashi, Keiichi Motoyama, Hidetoshi Arima, Kazumasa Yoshida, Nozomi Sugimoto, Hiroyuki Morimoto, Hidetaka Kosako, Takashi Ohshima & Masatoshi Fujita  (2019)  Identification of candidate molecular targets of the novel antineoplastic antimitotic NP-10 SCIENTIFIC REPORTS. 9 DOI:doi: 10.1038/s41598-019-53259-2
Tatsuhiro Igawa, Shuhei Kishikawa, Yoshito Abe, Tomohiro Yamashita, Saki Nagai, Mitsunori Shiroishi, Chinatsu Shinozaki, Hiroyuki Tanaka, Hidetoshi Tozaki-Saitoh, Makoto Tsuda, Kazuhide Inoue, and Tadashi Ueda (2019)  Evidence for detection of rat P2X4 receptor expressed on cells by generating monoclonal antibodies recognizing the native structure Purinergic Signal. 15 :1,  27-35 DOI:doi: 10.1007/s11302-019-09646-5
Shota Yamamoto Tomohiro Yamashita Mayu Ito Jose M.M. Caaveiro Nobuaki Egashira Hidetoshi Tozaki‐Saitoh Makoto Tsuda (2019)  New pharmacological effect of fulvestrant to prevent oxaliplatin‐induced neurodegeneration and mechanical allodynia in rats Int. J. cancer. 145 :8,  2017-2113 DOI:doi: 10.1002/ijc.32043
Shindo N, Fuchida H Sato H, Watari K, Shibata T, Kuwata K, Miura C, Okamoto K, Hatsuyama Y, Tokunag K, Sakamoto S, Morimoto S, Abe Y, Shiroishi M, Caaveiro JMM, Ueda T, Tamura T, Matsunaga N, Nakao T, Koyanagi S, Ohdo S, Yamaguchi Y, Hamachi I, Ono M, Ojida A. (2019)  Selective and Reversible Modification of Kinase Cysteines with Chlorofluoroacetamides. Nature Chem Biol. 15 250-258 DOI:doi: 0.1038/s41589-018-0204-3
Naoya Matsunaga, Yuya Yoshida, Naoki Kitajou, Akira Shiraishi, Naoki Kusunose, Satoru Koyanagi, Shigehiro Ohdo (2019)  Microcurrent stimulation activates the circadian machinery in mice Biochemical and Biophysical Research Communications. 513 :2,  293-299 DOI:doi: 10.1016/j.bbrc.2019.02.022
Rina Maeda, Shinsuke Sato, Shunsuke Obata, Tomo Ohno, Kaori Hashiya, Toshikazu Bando, Hiroshi Sugiyama (2019)  Molecular Characteristics of DNA-Alkylating PI Polyamides Targeting RUNX Transcription Factors J. Am. Chem. Soc.. 141 :10,  4257-4263 DOI:doi: 10.1021/jacs.8b08813
Riyo Maruki Imamura, Kazuo Kumagai, Hirofumi Nakano,Takayoshi Okabe, Tetsuo Nagano, and Hirotatsu Kojima (2019)  Inexpensive High-Throughput Screening of Kinase Inhibitors Using One-Step Enzyme-Coupled Fluorescence Assay SLAS Discovery. 24 :243,  284-294 DOI:DOI: 10.1177/2472555218810139
MasatoOgura, HaruhisaKikuchi, NorshalenaShakespear, ToshiyukiSuzuki, JunkoYamaki, Miwako K.Homma, YoshiteruOshima, YoshimiHomma (2019)  Prenylated quinolinecarboxylic acid derivative prevents neuronal cell death through inhibition of MKK4 Biochem Pharmacol.. 162 109-122 DOI:doi: 10.1016/j.bcp.2018.10.008.
Koji Sato, Naonori Kumagai and Norio Suzuki (2019)  Alteration of the DNA Methylation Signature of Renal Erythropoietin-Producing Cells Governs the Sensitivity to Drugs Targeting the Hypoxia-Response Pathway in Kidney Disease Progression Front. Genet. DOI:doi: 10.3389/fgene.2019.01134
Kosuke Ohsawa, Masato Sugai, Linnan Zhang, Yuichi Masuda, Masahito Yoshida, and Takayuki Doi (2019)  Total Synthesis and Structural Revision of Cyclotetrapeptide Asperterrestide A J.Org Chem. 84 6765-6779 DOI:doi: 10.1021/acs.joc.9b00526
Masahito Yoshida Kenta Adachi Hayato Murase Hiroshi Nakagawa Takayuki Doi (2019)  Parallel Synthesis and Biological Evaluation of Destruxin E Analogs Modified with a Side Chain in the α‐Hydroxycarboxylic Acid Moiety Eur.J. Org.Chem.. 84 1669-1676 DOI:Eur.J. Org.Chem.
Hiroko Izumi-Nakaseko, Masachika Fujiyoshi, Mihoko Hagiwara-Nagasawa, Ai Goto, Koki Chiba, Ryuichi Kambayashi, Atsuhiko T. Naito, Kentaro Ando, Yasunari Kanda, Itsuko Ishii, Atsushi Sugiyama (2019)  Dasatinib can Impair Left Ventricular Mechanical Function But May Lack Proarrhythmic Effect: A Proposal of Non-clinical Guidance for Predicting Clinical Cardiovascular Adverse Events of Tyrosine Kinase Inhibitors Cardiovasc Toxicol. . 1-13 DOI:doi: 10.1007/s12012-019-09538-5
Tomii K, Santos HJ, Nozaki T (2019)  Genome-Wide Analysis of Known and Potential Tetraspanins in Entamoeba histolytica Genes. 10 :11,  DOI:https://doi.org/10.3390/genes10110885
Kazuhisa Miyake, Ayuko Sakane, YukoTsuchiya, Ikuko Sagawa, YokoTomida, Jiro Kasahara, Issei Imoto, ShioWatanabe, Daisuke Higo, Kenji Mizuguchi & Takuya Sasaki (2019)  Actin Cytoskeletal Reorganization Function of JRAB/MICAL-L2 Is Fine-tuned by Intramolecular Interaction between First LIM Zinc Finger and C-terminal Coiled-coil Domains SCIENTIFIC REPORTS. 9 DOI:doi:10.1038/s41598-019-49232-8
Herbert J. Santos Kenichiro Imai Takashi Makiuchi Kentaro Tomii Paul Horton Akira Nozawa Kenta Okada Yuzuru Tozawa Tomoyoshi Nozaki (2019)  Novel lineage‐specific transmembrane β‐barrel proteins in the endoplasmic reticulum of Entamoeba histolytica The FEBS Journal. 286 :17,  3416-3432 DOI:https://doi.org/10.1111/febs.14870
Yuko Tsuchiya, Kei Taneishi, and Yasushige Yonezawa (2019)  Autoencoder-Based Detection of Dynamic Allostery Triggered by Ligand Binding Based on Molecular Dynamics J.Chem.Inf.Model.. 59 :9,  4043-4051 DOI:https://doi.org/10.1021/acs.jcim.9b00426
Yoshinori Fukasawa & Kentaro Tomii  (2019)  Accurate Classification of Biological and non-Biological Interfaces in Protein Crystal Structures using Subtle Covariation Signals SCIENTIFIC REPORTS. 9 DOI:https://doi.org/10.1038/s41598-019-48913-8
Hiroki Tanaka, Shoko Sato, Masako Koyama, Tomoya Kujirai, Hitoshi Kurumizaka (2019)  Biochemical and structural analyses of the nucleosome containing human histone H2A.J The Journal of Biochemistry. :in press,  1-25 DOI:https://doi.org/10.1093/jb/mvz109
Fumika Yakushiji,Aoi Ishikawa,Akira Katsuyama,Satoshi Ichikawa (2019)  Development of cyclic peptide derivatives from the N-terminal region of LANA for targeting the nucleosome acidic patch Bioorganic & Medicinal Chemistry Letters. :in press,  DOI:https://doi.org/10.1016/j.bmcl.2019.126839
Makoto Tsuda (2019)  Microglia-Mediated Regulation of Neuropathic Pain: Molecular and Cellular Mechanisms Biological and Pharmaceutical Bulletin. 42 :12,  1959-1968 DOI: https://doi.org/10.1248/bpb.b19-00715
Hiroko Kobayashi, Takeshi Sangawa, Katsuki Takebe, Naomi Motoyoshi, Tadashi Itagaki, Mamoru Suzuki (2019)  X-Ray Crystallographic Structure of Hericium erinaceus Ribonuclease, RNase He1 in Complex with Zinc Biological and Pharmaceutical Bulletin. 42 :12,  2054-2061 DOI:https://doi.org/10.1248/bpb.b19-00532
Hidetoshi Kono, Shun Sakuraba, Hisashi Ishida (2019)  Free energy profile for unwrapping outer superhelical turn of CENP-A nucleosome Biophysics and Physicobiology . 16 337-343 DOI:https://doi.org/10.2142/biophysico.16.0_337
Kei Moritsugu, Tsubasa Ito, Akinori Kidera (2019)  Allosteric response to ligand binding: Molecular dynamics study of the N-terminal domains in IP3 receptor Biophysics and Physicobiology . 16 232-239 DOI:https://doi.org/10.2142/biophysico.16.0_232
Kosuke Ohsawa, Hongbin Zhao, Takuya Tokunaga, Carys Thomas, A. Ganesan, Yuichi Masuda, Takayuki Doi (2019)  Stereoselective Synthesis of Protected l-allo-Enduracididine and l-Enduracididine via Asymmetric Nitroaldol Reaction Syn thesis. :51,  A-G DOI:DOI: 10.1055/s-0039-1691522
Tatsuya Furuichi, Manami Tsukamoto, Masaki Saito, Yuriko Sato, Nobuyasu Oiji, Kazuhiro Yagami, Ryutaro Fukumura, Yoichi Gondo, Long Guo, Shiro Ikegawa, Yu Yamamori, Kentaro Tomii (2019)  Crim1C140S mutant mice reveal the importance of cysteine 140 in the internal region 1 of CRIM1 for its physiological functions Mammalian Genome. 11-12 :30,  329-338 DOI:https://doi.org/10.1007/s00335-019-09822-3
Haruki Inada, Keisuke Furukawa, Masatoshi Shibuya, and Yoshihiko Yamamoto (2019)  One-pot, two-step synthesis of unnatural α-amino acids involving the exhaustive aerobic oxidation of 1,2-diols Chemical communications . 1-5 DOI: DOI: 10.1039/C9CC07889D.
Masashi Tachibana, Nobumasa Watanabe4, Yuzo Koda, Yukako Oya, Osamu Kaminuma, Kazufumi Katayama, Zifei Fan, Fuminori Sakurai, Kenji Kawabata5, Takachika Hiroi4, Hiroyuki Mizuguchi (2019)  Ablation of IL-17A leads to severe colitis in IL-10-deficient mice: implications of myeloid-derived suppressor cells and NO production International immunology. 1-46 DOI:https://doi.org/10.1093/intimm/dxz076
Yasumitsu Sakamoto, Yoshiyuki Suzuki, Akihiro Nakamura, Yurie Watanabe, Mizuki Sekiya, Saori Roppongi, Chisato Kushibiki, Ippei Iizuka, Osamu Tani, Hitoshi Sakashita, Koji Inaka, Hiroaki Tanaka, Mitsugu Yamada, Kazunori Ohta, Nobuyuki Honma, Yosuke Shida, Wataru Ogasawara, Mayumi Nakanishi-Matsui, Takamasa Nonaka, Hiroaki Gouda , Nobutada Tanaka  (2019)  Fragment-based discovery of the first nonpeptidyl inhibitor of an S46 family peptidase Scientific Reports. :in press,  DOI:https://doi.org/10.1038/s41598-019-49984-3
Saori Roppongi, Yoshiyuki Suzuki, Chika Tateoka, Mayu Fujimoto, Saori Morisawa, Ippei Iizuka, Akihiro Nakamura, Nobuyuki Honma, Yosuke Shida, Wataru Ogasawara, Nobutada Tanaka, Yasumitsu Sakamoto,Takamasa Nonaka  (2019)  Crystal structures of a bacterial dipeptidyl peptidase IV reveal a novel substrate recognition mechanism distinct from that of mammalian orthologues Scientific Reports. :in press,  DOI:DOI:10.1038/s41598-018-21056-y
Hiroshi Watanabe, Kimiko Kuroki, Chisato Yamada, Yukari Saburi, Naoyoshi Maeda, Katsumi Maenaka (2019)  Therapeutic effects of soluble human leukocyte antigen G2 isoform in lupus-prone MRL/lpr mice Human Immunology. :in press,  1-5 DOI:https://doi.org/10.1016/j.humimm.2019.11.002
Ryotaro Koike, Mutsuki Amano, Kozo Kaibuchi and Motonori Ota (2019)  Protein kinases phosphorylate long disordered regions in intrinsically disordered proteins Protein Science. 1-8 DOI:DOI10.1002/pro.3789
Yusuke Yoshikawa,Airi Ishibashi,Kenichi Murai,Yasufumi Kaneda,Keisuke Nimura,Mitsuhiro Arisawa (2019)  Design and Synthesis of a Phenyl C-Glycoside Derivative of Spliceostatin A and its Biological Evaluation toward Prostate Cancer Treatment Tetrahedron Letters. 60 :51,  DOI:https://doi.org/10.1016/j.tetlet.2019.151313
Shoya Shiromizu, Tomoaki Yamauchi, Naoki Kusunose, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo (2019)  Dosing Time-Dependent Changes in the Anti-tumor Effect of xCT Inhibitor Erastin in Human Breast Cancer Xenograft Mice Biological and Pharmaceutical Bulletin. 11 :42,  1921-1925 DOI: https://doi.org/10.1248/bpb.b19-00546
Suguru Morimoto, Masataka Tsuda, Heeyoun Bunch, Hiroyuki Sasanuma, Caroline Austin and Shunichi Takeda (2019)  Type II DNA Topoisomerases Cause Spontaneous Double-Strand Breaks in Genomic DNA Genes. 11 :10,  868- DOI:https://doi.org/10.3390/genes10110868
Shohei YOSHIOKA, Tsunayoshi Takehara, Tsuyoshi MATSUZAKI, Takeyuki Suzuki, Hirofumi Tsujino, Tadayuki Uno, Y Tsutumi, Kenichi Murai, Hiromichi Fujioka and Mitsuhiro Arisawa  (2019)  Direct Synthesis of Dialkylaryl-vinylsilane Derivatives: Metathesis of Dialkylaryl-iso-propenylsilane and Its Application to Tetracyclic Silacycle Dye Synthesis Chemical communications . 55 14070-14073 DOI: 10.1039/C9CC06777A.
Takumi Okuda , Yusuke Kawashima , Yuuya Kasahara , Tatsuya Takagi , Junpei Yamamoto , Shigenori Iwai , Satoshi Obika (2019)  Inhibiting guanine oxidation and enhancing excess-electron-transfer efficiency of a pyrene-modified oligonucleotide by introducing an electron-donating group on pyrene Chemical Communications. 55 14062-14065 DOI:DOI: 10.1039/C9CC06498B
Yoshiaki Shimazu, Kensuke Tono, Tomoyuki Tanaka, Yasuaki Yamanaka, Takanori Nakane, Chihiro Mori, Kanako Terakado Kimura, Takaaki Fujiwara, Michihiro Sugahara, Rie Tanaka, R. Bruce Doak, Tatsuro Shimamura, So Iwata, Eriko Nango, and Makina Yabashi (2019)  High-viscosity sample-injection device for serial femtosecond crystallography at atmospheric pressure Journal of Applied Crystallography. 52 1280-1288 DOI:https://doi.org/10.1107/S1600576719012846
Mohammad Bozlul Karim, Shigehiko Kanaya and Md. Altaf-Ul-Amin (2019)  Implementation of BiClusO and its comparison with other biclustering algorithms Applied Network Science. 4:79 1-15 DOI:https://doi.org/10.1007/s41109-019-0180-x
Kanako Nozawa-Kumada, Shungo Ito, Koto Noguchi, Masanori Shigeno and Yoshinori Kondo (2019)  Super electron donor-mediated reductive desulfurization reactions Chemical communications . 55 12968-12971 DOI:10.1039/c9cc06775b
Kanako Nozawa-Kumada, Kosuke Nakamura, Satoshi Kurosu, Yuki Iwakawa, Charline Denneval, Masanori Shigeno, Yoshinori Kondo (2019)  Tetramethylammonium Fluoride Tetrahydrate-Mediated Transition Metal-Free Coupling of Aryl Iodides with Unactivated Arenes in Air Chemical and Pharmaceutical Bulletin. 67 :10,  1042-1045 DOI:doi.org/10.1248/cpb.c19-00452
Akane Fujii Osamu Nakagawa Yuki Kishimoto Yusuke Nakatsuji Natsumi Nozaki Satoshi Obika (2019)  Triplex‐forming Abilities and Fluorescent Properties of Oligonucleotides Containing Phenoxazine Artificial Nucleobases CHEM BIO CHEM. :in press,  DOI:doi.org/10.1002/cbic.201900536
M. Saotome, N. Horikoshi, K. Urano, T. Kujirai, H. Yuzurihara, H. Kurumizaka W. Kagawa (2019)  Structure determination of the nucleosome core particle by selenium SAD phasing Acta Crystallographica Section D. 75 :10,  1-6 DOI:https://doi.org/10.1107/S2059798319012713
Miki Okada-Iwabu, Masato Iwabu, Toshimasa Yamauchi, Takashi Kadowaki (2019)  Drug development research for novel adiponectin receptor-targeted antidiabetic drugs contributing to healthy longevity Diabetology International. 4 :19,  237-244 DOI:https://doi.org/10.1007/s13340-019-00409-6
AnamikaSharma, Rotimi Sheyi, Ashish Kumar, Ayman El-Faham, Beatriz G. de la Torre, and Fernando Albericio (2019)  Investigating Triorthogonal Chemoselectivity. Effect of Azide Substitution on the Triazine Core Organic letters. 21 7888-7892 DOI: https://doi.org/10.1021/acs.orglett.9b02878
Takahisa Taniguchi , Nozomi Saito , Ryohei Doi , Arato Kimoto , Naoyuki Hoshiya , Katsumasa Fujiki , Satoshi Shuto , Hiromichi Fujioka , Mitsuhiro Arisawa , and Yoshihiro Sato  (2019)  Nickel Nanoparticle-Catalyzed Carboxylation of Unsaturated Hydrocarbon with CO2 Using Sulfur-Modified Au-Supported Nickel Material chemistry letters. 48 :11,  1406-1409 DOI:https://doi.org/10.1246/cl.190650
Ayumu Kawase ,Hirotaka Omura ,Takayuki Doi , and Hirokazu Tsukamoto  (2019)  Palladium(0)-Catalyzed [4+2] Annulation of Salicylaldehydes and Propargyl Carbonates to Produce 3,4-Dihydro-2-Methylene-2H-1-Benzopyran-4-Ols chemistry letters. 48 :11,  1402-1405 DOI:https://doi.org/10.1246/cl.190642
Jyuan C. Sanchez, Melissa Carrillo, Suraj Pandey, Moraima Noda, Luis Aldama, Denisse Feliz, Elin Claesson, Weixiao Yuan Wahlgren, Gregory Tracy, Phu Duong, Angela C. Nugent, Andrew Field, Vukica Šrajer, Christopher Kupitz, So Iwata, Eriko Nango, Rie Tanaka, Tomoyuki Tanaka, Luo Fangjia, Kensuke Tono, Shigeki Owada, Sebastian Westenhoff, Marius Schmidt, and Emina A. Stojković (2019)  High-resolution crystal structures of a myxobacterial phytochrome at cryo and room temperatures Structural Dynamics . 54701 :6,  1-9 DOI:https://doi.org/10.1063/1.5120527
YukiKanado, YuyaTsurudome, YujiOmata, SaiYasukochi, NaokiKusunose, TakahiroAkamine, NaoyaMatsunaga, SatoruKoyanagi, ShigehiroOhdo (2019)  Estradiol regulation of P-glycoprotein expression in mouse kidney and human tubular epithelial cells, implication for renal clearance of drugs Biochemical and Biophysical Research Communications. 519 :3,  613-619 DOI:https://doi.org/10.1016/j.bbrc.2019.09.021
Hideyuki Konishi, Kei Manabe (2019)  Recent progress on catalytic Heck carbonylations using carbon monoxide surrogates Tetrahedron Letters. 60 :42,  1-7 DOI:https://doi.org/10.1016/j.tetlet.2019.151147
Péter Horváth, Takayuki Kato, Tomoko Miyata and Keiichi Namba (2019)  Structure of Salmonella Flagellar Hook Reveals Intermolecular Domain Interactions for the Universal Joint Function Biomolecules. 9 :9,  462-462 DOI:https://doi.org/10.3390/biom9090462
Yuuri Yasuoka, Masahito Matsumoto, Ken Yagi, and Yasushi Okazaki (2019)  Evolutionary History of GLIS Genes Illuminates their Roles in Cell Reprogramming and Ciliogenesis Molecular Biology and Evolution. :msz205,  1-10 DOI:https://doi.org/10.1093/molbev/msz205
Yuta Ito, Akihiro Touyama, Minako Uku, Hiromichi Egami, Yoshitaka Hamashima (2019)  Thiocyanation of Aromatic and Heteroaromatic Compounds with 1-Chloro-1,2-benziodoxol-3-(1H)-one and (Trimethylsilyl)isothiocyanate Chemical and Pharmaceutical Bulletin. 9 :67,  1015-1018 DOI:https://doi.org/10.1248/cpb.c19-00352
Keisuke Tachibana, Masuo Kondoh (2019)  A Method to Prepare Claudin-Modulating Recombinant Proteins Springer Nature. :in press,  DOI:https://doi.org/10.1007/7651_2019_258
M. Takenoya, T. Shimamura, R. Yamanaka, Y. Adachi, S. Ito, Y. Sasaki, A. Nakamura and S. Yajima (2019)  Structural basis for the substrate recognition of aminoglycoside 7′′-phosphotransferase-Ia from Streptomyces hygroscopicus Acta Crystallographica Section F. :F75,  599-607 DOI: https://doi.org/10.1107/S2053230X19011105
Rui Tang, Atsushi Kimishima, Ryosuke Ishida, Andi Setiawan, Masayoshi Arai (2019)  Selective cytotoxicity of epidithiodiketopiperazine DC1149B, produced by marine-derived Trichoderma lixii on the cancer cells adapted to glucose starvation Journal of Natural Medicines . 1-7 DOI:https://doi.org/10.1007/s11418-019-01357-w
Yoshito Zamami, Takahiro Niimura, Naoto Okada, et al (2019)  Factors Associated With Immune Checkpoint Inhibitor–Related Myocarditis Operations Research Letters. 5 :11,  1635-1637 DOI:doi:10.1001/jamaoncol.2019.3113
Ashutosh Kumar, Kam Y. J. Zhang (2019)  Improving ligand 3D shape similarity-based pose prediction with a continuum solvent model Journal of Computer-Aided Molecular Design. 33 :12,  1045-1055 DOI: https://doi.org/10.1007/s10822-019-00220-0 PMID:31463704  
Hideo Fukuhara, Yuri Ito, Miyuki Sako, Mizuho Kajikawa, Koki Yoshida, Fumio Seki, Mwila Hilton Mwaba, Takao Hashiguchi, Masa-aki Higashibata, Toyoyuki Ose, Kimiko Kuroki, Makoto Takeda and Katsumi Maenaka (2019)  Specificity of Morbillivirus Hemagglutinins to Recognize SLAM of Different Species Viruses. 11 :8,  DOI:https://doi.org/10.3390/v11080761
"Takeru Chigira,Satoru Nagatoishi,Hiroyuki Takeda,Tetsuro Yoshimaru, Toyomasa Katagiri,Kouhei Tsumoto" (2019)  Biophysical characterization of the breast cancer-related BIG3-PHB2 interaction: Effect of non-conserved loop region of BIG3 on the structure and the interaction Biochemical and Biophysical Research Communications. 518 :1,  183-189 DOI:https://doi.org/10.1016/j.bbrc.2019.08.028
Hirofumi Tsujino,Tadayuki Uno,Taku Yamashita,Masafumi Katsuda,Kazuki Takada,Takeshi Saiki,Shotaro Maeda,Akira Takagi,Shigeaki Masuda,Yasuhiko Kawano,Kanji Meguro,Shuji Akai (2019)  Correlation of indoleamine-2,3-dioxigenase 1 inhibitory activity of 4,6-disubstituted indazole derivatives and their heme binding affinity Bioorganic & Medicinal Chemistry Letters. 29 :19,  DOI:https://doi.org/10.1016/j.bmcl.2019.08.011
Zichang Xu, Songling Li, John Rozewicki, Kazuo Yamashita, Shunsuke Teraguchi, Takeshi Inoue, Ryo Shinnakasu, Sarah Leach, Tomohiro Kurosaki and Daron M. Standley (2019)  Functional clustering of B cell receptors using sequence and structural features The Royal Society of Chemistry. 4 769-778 DOI:10.1039/c9me00021f
Eiki Yamashita, Atsushi Nakagawa (2019)  SPring-8 BL44XU, a synchrotron radiation beamline for biological macromolecular assemblies, operated by the Institute for Protein Research, Osaka University Biophysical Reviews. 11 :4,  521-523 DOI:https://doi.org/10.1007/s12551-019-00557-8
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