成果

創薬等先端技術支援基盤プラットフォーム(BINDS)の支援実施者による支援技術に関する研究成果と、BINDSの支援を受けた外部研究者の研究成果(論文)を紹介しています。

開発されたデータベースやツール

ケミカルシーズ・リード 探索ユニット

インシリコユニット

プラットフォーム機能最適化ユニット

BINDS支援技術に関する研究成果(論文)

Hiromitsu Araki, Fumihito Miura, Akira Watanabe, Chikako Morinaga, Fumiyo Kitaoka, Yuko Kitano, Noriko Sakai, Yumiko Shibata, Motoki Terada, So Goto, Shinya Yamanaka, Masayo Takahashi, Takashi Ito (2019)  Base-Resolution Methylome of Retinal Pigment Epithelial Cells Used in the First Trial of Human Induced Pluripotent Stem Cell-Based Autologous Transplantation. Stem Cell Reports. 13 :4,  761-774 DOI:10.1016/j.stemcr.2019.08.014 PMID:31564644 
Fumihito Miura, Yukiko Shibata, Miki Miura, Yuhei Sangatsuda, Osamu Hisano, Hiromitsu Araki, Takashi Ito (2019)  Highly efficient single-stranded DNA ligation technique improves low-input whole-genome bisulfite sequencing by post-bisulfite adaptor tagging. Nucleic Acids Research. 47 :15,  e85- DOI:10.1093/nar/gkz435 PMID:31114914 

BINDSの支援を受けた研究成果(論文)

Hiroshi Watanabe, Kimiko Kuroki, Chisato Yamada, Yukari Saburi, Naoyoshi Maeda, Katsumi Maenaka (2019)  Therapeutic effects of soluble human leukocyte antigen G2 isoform in lupus-prone MRL/lpr mice Human Immunology. :in press,  1-5 DOI:https://doi.org/10.1016/j.humimm.2019.11.002
Ryotaro Koike, Mutsuki Amano, Kozo Kaibuchi and Motonori Ota (2019)  Protein kinases phosphorylate long disordered regions in intrinsically disordered proteins Protein Science. 1-23 DOI:DOI10.1002/pro.3789
Yusuke Yoshikawa,Airi Ishibashi,Kenichi Murai,Yasufumi Kaneda,Keisuke Nimura,Mitsuhiro Arisawa (2019)  Design and Synthesis of a Phenyl C-Glycoside Derivative of Spliceostatin A and its Biological Evaluation toward Prostate Cancer Treatment Tetrahedron Letters. :in press,  DOI:https://doi.org/10.1016/j.tetlet.2019.151313
Shoya Shiromizu, Tomoaki Yamauchi, Naoki Kusunose, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo (2019)  Dosing Time-Dependent Changes in the Anti-tumor Effect of xCT Inhibitor Erastin in Human Breast Cancer Xenograft Mice Biological and Pharmaceutical Bulletin. 11 :42,  1921-1925 DOI: https://doi.org/10.1248/bpb.b19-00546
Suguru Morimoto, Masataka Tsuda, Heeyoun Bunch, Hiroyuki Sasanuma, Caroline Austin andShunichi Takeda (2019)  Type II DNA Topoisomerases Cause Spontaneous Double-Strand Breaks in Genomic DNA Genes. 11日 :10,  868- DOI:https://doi.org/10.3390/genes10110868
Shohei YOSHIOKA, Tsunayoshi Takehara, Tsuyoshi MATSUZAKI, Takeyuki Suzuki, Hirofumi Tsujino, Tadayuki Uno, Y Tsutumi, Kenichi Murai, Hiromichi Fujioka and Mitsuhiro Arisawa  (2019)  Direct Synthesis of Dialkylaryl-vinylsilane Derivatives: Metathesis of Dialkylaryl-iso-propenylsilane and Its Application to Tetracyclic Silacycle Dye Synthesis Chemical communications . DOI: 10.1039/C9CC06777A.
Takumi Okuda , Yusuke Kawashima , Yuuya Kasahara , Tatsuya Takagi , Junpei Yamamoto , Shigenori Iwai , Satoshi Obika (2019)  Inhibiting guanine oxidation and enhancing excess-electron-transfer efficiency of a pyrene-modified oligonucleotide by introducing an electron-donating group on pyrene Chemical Communications. :in press,  DOI:DOI: 10.1039/C9CC06498B
Yoshiaki Shimazu, Kensuke Tono, Tomoyuki Tanaka, Yasuaki Yamanaka, Takanori Nakane, Chihiro Mori, Kanako Terakado Kimura, Takaaki Fujiwara, Michihiro Sugahara, Rie Tanaka, R. Bruce Doak, Tatsuro Shimamura, So Iwata, Eriko Nango, and Makina Yabashi (2019)  High-viscosity sample-injection device for serial femtosecond crystallography at atmospheric pressure Journal of Applied Crystallography. 52 DOI:https://doi.org/10.1107/S1600576719012846
Mohammad Bozlul Karim, Shigehiko Kanaya and Md. Altaf-Ul-Amin (2019)  Implementation of BiClusO and its comparison with other biclustering algorithms Applied Network Science. :in press,  DOI:https://doi.org/10.1007/s41109-019-0180-x
Kanako Nozawa-Kumada, Shungo Ito, Koto Noguchi, Masanori Shigeno and Yoshinori Kondo (2019)  Super electron donor-mediated reductive desulfurization reactions Chemical communications . :in press,  DOI:10.1039/c9cc06775b
Kanako Nozawa-Kumada, Kosuke Nakamura, Satoshi Kurosu, Yuki Iwakawa, Charline Denneval, Masanori Shigeno, Yoshinori Kondo (2019)  Tetramethylammonium Fluoride Tetrahydrate-Mediated Transition Metal-Free Coupling of Aryl Iodides with Unactivated Arenes in Air Chemical and Pharmaceutical Bulletin. 67 :10,  1042-1045 DOI:doi.org/10.1248/cpb.c19-00452
Akane Fujii Osamu Nakagawa Yuki Kishimoto Yusuke Nakatsuji Natsumi Nozaki Satoshi Obika (2019)  Triplex‐forming Abilities and Fluorescent Properties of Oligonucleotides Containing Phenoxazine Artificial Nucleobases CHEM BIO CHEM. :in press,  DOI:doi.org/10.1002/cbic.201900536
M. Saotome, N. Horikoshi, K. Urano, T. Kujirai, H. Yuzurihara, H. Kurumizaka W. Kagawa (2019)  Structure determination of the nucleosome core particle by selenium SAD phasing Acta Crystallographica Section D. 75 :10,  1-6 DOI:https://doi.org/10.1107/S2059798319012713
Miki Okada-Iwabu, Masato Iwabu, Toshimasa Yamauchi, Takashi Kadowaki (2019)  Drug development research for novel adiponectin receptor-targeted antidiabetic drugs contributing to healthy longevity Diabetology International. 4 :19,  237-244 DOI:https://doi.org/10.1007/s13340-019-00409-6
AnamikaSharma, Rotimi Sheyi, Ashish Kumar, Ayman El-Faham, Beatriz G. de la Torre, and Fernando Albericio (2019)  Investigating Triorthogonal Chemoselectivity. Effect of Azide Substitution on the Triazine Core Organic letters. :in press,  DOI: https://doi.org/10.1021/acs.orglett.9b02878
Takahisa Taniguchi , Nozomi Saito , Ryohei Doi , Arato Kimoto , Naoyuki Hoshiya , Katsumasa Fujiki , Satoshi Shuto , Hiromichi Fujioka , Mitsuhiro Arisawa , and Yoshihiro Sato  (2019)  Nickel Nanoparticle-Catalyzed Carboxylation of Unsaturated Hydrocarbon with CO2 Using Sulfur-Modified Au-Supported Nickel Material chemistry letters. :in press,  DOI:https://doi.org/10.1246/cl.190650
Ayumu Kawase ,Hirotaka Omura ,Takayuki Doi , and Hirokazu Tsukamoto  (2019)  Palladium(0)-Catalyzed [4+2] Annulation of Salicylaldehydes and Propargyl Carbonates to Produce 3,4-Dihydro-2-Methylene-2H-1-Benzopyran-4-Ols chemistry letters. :in press,  DOI:https://doi.org/10.1246/cl.190642
Jyuan C. Sanchez, Melissa Carrillo, Suraj Pandey, Moraima Noda, Luis Aldama, Denisse Feliz, Elin Claesson, Weixiao Yuan Wahlgren, Gregory Tracy, Phu Duong, Angela C. Nugent, Andrew Field, Vukica Šrajer, Christopher Kupitz, So Iwata, Eriko Nango, Rie Tanaka, Tomoyuki Tanaka, Luo Fangjia, Kensuke Tono, Shigeki Owada, Sebastian Westenhoff, Marius Schmidt, and Emina A. Stojković (2019)  High-resolution crystal structures of a myxobacterial phytochrome at cryo and room temperatures Structural Dynamics . 54701 :6,  1-9 DOI:https://doi.org/10.1063/1.5120527
YukiKanado, YuyaTsurudome, YujiOmata, SaiYasukochi, NaokiKusunose, TakahiroAkamine, NaoyaMatsunaga, SatoruKoyanagi, ShigehiroOhdo (2019)  Estradiol regulation of P-glycoprotein expression in mouse kidney and human tubular epithelial cells, implication for renal clearance of drugs Biochemical and Biophysical Research Communications. :in press,  DOI:https://doi.org/10.1016/j.bbrc.2019.09.021
Hideyuki Konishi, Kei Manabe (2019)  Recent progress on catalytic Heck carbonylations using carbon monoxide surrogates Tetrahedron Letters. :in press,  DOI:https://doi.org/10.1016/j.tetlet.2019.151147
Péter Horváth, Takayuki Kato, Tomoko Miyata and Keiichi Namba (2019)  Structure of Salmonella Flagellar Hook Reveals Intermolecular Domain Interactions for the Universal Joint Function Biomolecules. 9 :9,  462-462 DOI:https://doi.org/10.3390/biom9090462
Yuuri Yasuoka, Masahito Matsumoto, Ken Yagi, and Yasushi Okazaki (2019)  Evolutionary History of GLIS Genes Illuminates their Roles in Cell Reprogramming and Ciliogenesis Molecular Biology and Evolution. :msz205,  1-31 DOI:https://doi.org/10.1093/molbev/msz205
Yuta Ito, Akihiro Touyama, Minako Uku, Hiromichi Egami, Yoshitaka Hamashima (2019)  Thiocyanation of Aromatic and Heteroaromatic Compounds with 1-Chloro-1,2-benziodoxol-3-(1H)-one and (Trimethylsilyl)isothiocyanate Chemical and Pharmaceutical Bulletin. 9 :67,  1015-1018 DOI:https://doi.org/10.1248/cpb.c19-00352
Keisuke Tachibana, Masuo Kondoh (2019)  A Method to Prepare Claudin-Modulating Recombinant Proteins Springer Nature. :in press,  DOI:https://doi.org/10.1007/7651_2019_258
M. Takenoya, T. Shimamura, R. Yamanaka, Y. Adachi, S. Ito, Y. Sasaki, A. Nakamura and S. Yajima (2019)  Structural basis for the substrate recognition of aminoglycoside 7′′-phosphotransferase-Ia from Streptomyces hygroscopicus Acta Crystallographica Section F. :F75,  599-607 DOI: https://doi.org/10.1107/S2053230X19011105
Rui Tang, Atsushi Kimishima, Ryosuke Ishida, Andi Setiawan, Masayoshi Arai (2019)  Selective cytotoxicity of epidithiodiketopiperazine DC1149B, produced by marine-derived Trichoderma lixii on the cancer cells adapted to glucose starvation Journal of Natural Medicines . :in press,  DOI:https://doi.org/10.1007/s11418-019-01357-w
Yoshito Zamami, Takahiro Niimura, Naoto Okada, et al (2019)  Factors Associated With Immune Checkpoint Inhibitor–Related Myocarditis Operations Research Letters. :in press,  DOI:doi:10.1001/jamaoncol.2019.3113
Ashutosh Kumar, Kam Y. J. Zhang (2019)  Improving ligand 3D shape similarity-based pose prediction with a continuum solvent model Journal of Computer-Aided Molecular Design. :in press,  DOI: https://doi.org/10.1007/s10822-019-00220-0
Hideo Fukuhara, Yuri Ito, Miyuki Sako, Mizuho Kajikawa, Koki Yoshida, Fumio Seki, Mwila Hilton Mwaba, Takao Hashiguchi, Masa-aki Higashibata, Toyoyuki Ose, Kimiko Kuroki, Makoto Takeda and Katsumi Maenaka (2019)  Specificity of Morbillivirus Hemagglutinins to Recognize SLAM of Different Species Viruses. 11 :8,  DOI:https://doi.org/10.3390/v11080761
"Takeru Chigira,Satoru Nagatoishi,Hiroyuki Takeda,Tetsuro Yoshimaru, Toyomasa Katagiri,Kouhei Tsumoto" (2019)  Biophysical characterization of the breast cancer-related BIG3-PHB2 interaction: Effect of non-conserved loop region of BIG3 on the structure and the interaction Biochemical and Biophysical Research Communications. 1-7 DOI:https://doi.org/10.1016/j.bbrc.2019.08.028
Hirofumi Tsujino,Tadayuki Uno,Taku Yamashita,Masafumi Katsuda,Kazuki Takada,Takeshi Saiki,Shotaro Maeda,Akira Takagi,Shigeaki Masuda,Yasuhiko Kawano,Kanji Meguro,Shuji Akai (2019)  Correlation of indoleamine-2,3-dioxigenase 1 inhibitory activity of 4,6-disubstituted indazole derivatives and their heme binding affinity Bioorganic & Medicinal Chemistry Letters. 1-6時 DOI:https://doi.org/10.1016/j.bmcl.2019.08.011
Zichang Xu, Songling Li, John Rozewicki, Kazuo Yamashita, Shunsuke Teraguchi, Takeshi Inoue, Ryo Shinnakasu, Sarah Leach, Tomohiro Kurosaki and Daron M. Standley (2019)  Functional clustering of B cell receptors using sequence and structural features The Royal Society of Chemistry. DOI:10.1039/c9me00021f
Eiki Yamashita, Atsushi Nakagawa (2019)  SPring-8 BL44XU, a synchrotron radiation beamline for biological macromolecular assemblies, operated by the Institute for Protein Research, Osaka University Biophysical Reviews. :in press,  1-3 DOI:https://doi.org/10.1007/s12551-019-00557-8
TakashiKatayama, ShintaroKinugawa, ShingoTakada, TakaakiFurihata, ArataFukushima, TakashiYokota, ToshihisaAnzai, MitsueHibino, HideyoshiHarashima, YumaYamada (2019)  A mitochondrial delivery system using liposome-based nanocarriers that target myoblast cells Science Direct. :in press,  DOI:https://doi.org/10.1016/j.mito.2019.07.005
Takahiro Jomori, Yasumasa Hara, Miho Sasaoka, Kazuo Harada, Andi Setiawan, Kazumasa Hirata, Atsushi Kimishima, Masayoshi Arai (2019)  Mycobacterium smegmatis alters the production of secondary metabolites by marine-derived Aspergillus niger Journal of Natural Medicines . :18,  1-7 DOI:https://doi.org/10.1007/s11418-019-01345-0
NaohiroKatagiri, SatoruNagatoishi, KouheiTsumoto, HideyaEndo (2019)  Structural features of methionine aminopeptidase2-active corepeptide essential for binding with S100A4 Biochemical and Biophysical Research Communications. :in press,  DOI:https://doi.org/10.1016/j.bbrc.2019.07.006
HiroyukiMiyachi, TomohiroYuzuriha, RyotaroTabata, SyoheiFukuda, KazutoNunomura, BangzhongLin, TadayukiKobayashi, KenjiIshimoto, TakefumiDoi, KeisukeTachibana (2019)  Structural development of 1H-pyrazolo-[3,4-b]pyridine-4-carboxylic acid derivatives as human peroxisome proliferator-activated receptor alpha (PPARα)-selective agonists Bioorganic & Medicinal Chemistry Letters. :in press,  DOI:https://doi.org/10.1016/j.bmcl.2019.06.062
Dimitri Schritt, Songling Li, John Rozewicki, Kazutaka Katoh, Kazuo Yamashita, Wayne Volkmuth, Guy Cavetc and Daron M. Standley (2019)  Repertoire Builder: high-throughput structural modeling of B and T cell receptors Royal Society of Chemistry. DOI:DOI: 10.1039/c9me00020h
Masaya Mori , Yuuta Fujikawa , Manami Kikkawa , Moeho Shino , Mei Sawane , Shiho Sato and Hideshi Inoue (2019)  A highly selective fluorogenic substrate for imaging glutathione Stransferase P1: development, and cellular applicability to epigenetic studies Chem. Comm.. DOI:DOI: 10.1039/x0xx00000x
Masayoshi Arai (2019)  Exploring Bioactive Marine Natural Products and Identification of Their Molecular Targets Springer. 291-303 DOI:https://doi.org/10.1007/978-981-13-6244-6_12
Suguru Yoshida,Takamitsu Hosoya  (2019)  Target Identification of Bioactive Compounds by Photoaffinity Labeling Using Diazido Probes Springer. 335-355 DOI:https://doi.org/10.1007/978-981-13-6244-6_14
Hiromichi Tanaka ,Hideyuki Konishi , Kei Manabe  (2019)  Palladium-Catalyzed One-Step Synthesis of Symmetrical Diaryl Sulfones from Aryl Halides and a Sulfur Dioxide Surrogate The Chemical Society of Japan. DOI:https://doi.org/10.1246/cl.190300
T. Shimo, K.Tachibana, Y. Kawawaki, Y. Watahiki, T. Ishigaki, Y. Nakatsuji, T. Hara, J. Kawakami ,S. Obika (2019)  Enhancement of exon skipping activity by reduction in secondary structure content of LNA-based splice-switching oligonucleotides ChemComm. 1-3 DOI:DOI: 10.1039/C8CC09648A
Jumpei Kondo , Masahiro Inoue  (2019)  Application of Cancer Organoid Model for Drug Screening and Personalized Therapy cells. 5 :8,  470-470 DOI:http://dx.doi.org/10.3390/cells8050470
Hidenori Hirai, Kyoko Matoba, Emiko Mihara, Takao Arimori , Junichi Takagi (2019)  Crystal structure of a mammalian Wnt–frizzled complex Nature Structural & Molecular Biologyvolume. :26,  372-379 DOI:https://doi.org/10.1038/s41594-019-0216-z
John Rozewicki, Songling Li, Karlou Mar Amada, Daron M. Standley, and Kazutaka Katoh (2019)  MAFFT-DASH: integrated protein sequence and structural alignment Nucleic Acids Research. 1 DOI:doi: 10.1093/nar/gkz342
Boonmin Poh, Hideto Koso, Hiroyuki Momota, Takashi Komori, Yutaka Suzuki, Nobuaki Yoshida, Yasushi Ino, Tomoki Todo, Sumiko Watanabe (2019)  Foxr2 promotes formation of CNS-embryonal tumors in a Trp53-deficient background Neuro-Oncology. noz067 1-28 DOI:https://doi.org/10.1093/neuonc/noz067
Daiki Hayashi, Ryosuke Tsumagari, Ke Liu, Shuji Ueda, Minoru Yamanoue,Fumio Sakane and Yasuhito Shirai (2019)  Screening of subtype-specific activators and inhibitors for diacylglycerol kinase The Journal of Biochemistry. 1-6 DOI:10.1093/jb/mvz008
Yosuke Sakata, Kosuke Yabunaka, Yuko Kobayashi, Hirohisa Omiya, Naoki Umezawa , Hye-Sook Kim, Yusuke Wataya, Yoshimi Tomita, Yosuke Hisamatsu, Nobuki Kato, Hirokazu Yagi, Tadashi Satoh, Koichi Kato¶, Haruto Ishikawa, and Tsunehiko Higuchi (2019)  Potent Antimalarial Activity of Two Arenes Linked with Triamine Designed To Have Multiple Interactions with Heme ACS Medicinal. Chemistry. Letters. 9 :10,  980-985 DOI:10.1021/acsmedchemlett.8b00222
Sebastian A. Andrei, Pim de Vink, Eline Sijbesma, Ling Han, Prof. Luc Brunsveld, Prof. Nobuo Kato, Prof. Christian Ottmann, Dr. Yusuke Higuchi (2019)  Rationally Designed Semisynthetic Natural Product Analogues for Stabilization of 14‐3‐3 Protein–Protein Interactions A Journal of the German Chemical Society. 57 :41,  13470-13474 DOI:10.1002/anie.201806584 PMID:30025189 
Akinobu Senoo, Satoru Nagatoishi, Anna Moberg, Linnea Nygren Babol, Tomoya Mitani, Takumi Tashima, Shota Kudo, Kouhei Tsumoto (2019)  Inhibition of homophilic dimerization and disruption of cell adhesion by P-cadherin-specific small molecules from SPR-based assays Chemical communications . 54 :42,  5350-5353 DOI: 10.1039/C8CC01964A
Taito Matsuda, Takashi Irie, Shutaro Katsurabayashi, Yoshinori Hayashi, Tatsuya Nagai, Nobuhiko Hamazaki, Aliya Mari D Adefuin, Fumihito Miura, Takashi Ito, Hiroshi Kimura, Katsuhiko Shirahige, Tadayuki Takeda, Katsunori Iwasaki, Takuya Imamura, Kinichi Nakashima (2019)  Pioneer factor NeuroD1 rearranges transcriptional and epigenetic profiles to execute microglia-neuron conversion. Neuron. 101 :3,  472-485 DOI:10.1016/j.neuron.2018.12.010. PMID:30638745