成果

創薬等先端技術支援基盤プラットフォーム(BINDS)の支援実施者による支援技術に関する研究成果と、BINDSの支援を受けた外部研究者の研究成果(論文)を紹介しています。

BINDS支援技術に関する研究成果(論文)

Terada N, Karim MR, Izawa T, Kuwamura M, Yamate J. (2018)  Expression of β-catenin in regenerating renal tubules of the cisplatin-induced kidney failure in rats. Clinical and Experimental Nephrology. DOI:10.1007/s10157-018-1583-1
Pervin M, Karim MR, Kuramochi M, Izawa T, Kuwamura M, Yamate J.  (2018)  Macrophage populations and expression of regulatory inflammatory factors in hepatic macrophage-depleted rat livers under lipopolysaccharide (LPS) treatment. Toxicologic Pathology. DOI:10.1177/0192623318776898 PMID:29938593 
Kaneko H, Ikawa T, Yamamoto Y, Arulmozhiraja S, Tokiwa H, Akai S (2018)  3-(Triflyloxy)benzynes Enable the Regiocontrolled Cycloaddition of Cyclic Ureas to Synthesize 1,4-Benzodiazepine Derivatives Synlett. 7 :29,  943-948 DOI:10.1055/s-0036-1591924
Shirakura K, Ishiba R, Kashio T, Sakai M, Fukushima Y, Yamamoto N, Manabe S, Shigesada N, Tanaka T, Hino N, Aird WC, Doi T, Okada Y (2018)  Endothelial Robo4 regulates IL-6 production by endothelial cells and monocytes via a crosstalk mechanism in inflammation Biochem Biophys Res Commun. 1 :495,  801-806 DOI:10.1016/j.bbrc.2017.11.067
Suroto DA, Kitani S, Miyamoto KT, Sakihama Y, Arai M, Ikeda H, Nihira T (2017)  Activation of cryptic phthoxazolin A production in Streptomyces avermitilis by the disruption of autoregulator-receptor homologue AvaR3 Journal of Bioscience and Bioengineering. 6 :124,  611-617 DOI:10.1016/j.jbiosc.2017.06.014
Takubo K, Mohamed A, Ide T, Saito K, Ikawa T, Yoshimitsu T, Akai S (2017)  Regioselective Rearrangement of 4,4-Disubstituted 2-Hydroxycyclohexa- 2,5-dienones under Deoxyfluorination Conditions J. Org. Chem.. 24 :82,  13141-13151 DOI:10.1021/acs.joc.7b02208
Watari A, Kodaka M, Matsuhisa K, Sakamoto Y, Hisaie K, Kawashita N, Takagi T, Yamagishi Y, Suzuki H, Tsujino H, Yagi K, Kondoh M (2017)  Identification of claudin-4 binder that attenuates tight junction barrier function by TR-FRET-based screening assay Sci Rep.. :7,  DOI:10.1038/s41598-017-15108-y
Kishimoto Y, Fujii A, Nakagawa O, Nagata T, Yokota T, Hari Y, Obika S (2017)  Synthesis and thermal stabilities of oligonucleotides containing 2’-O,4’-C-methylene bridged nucleic acid with a phenoxazine base Org. Biomol. Chem.. :15,  8145-8152 DOI:10.1039/c7ob01874f
Takamoto K, Ohno S, Hyogo N, Fujioka H, Arisawa M (2017)  Ruthenium-Catalyzed 1,6-Aromatic Enamide−Silylalkyne Cycloisomerization: Approach to 2,3-Disubstituted Indoles J. Org. Chem. . 16 :82,  8733-8742 DOI:10.1021/acs.joc.7b01288
Yoshioka S, Fujii Y, Fujino H, Uno T, Fujioka H, Arisawa M (2017)  One-pot Enyne Metathesis/Diels–Alder/Oxidation to Six-membered Silacycles with a Multi-ring Core: Discovery of Novel Fluorophores Chem. Commun. :53,  5970-5973 DOI:10.1039/C7CC02788E
Akiyama T, Taniguchi T, Saito N, Doi R, Honma T, Tamenori Y, Ohki Y, Takahashi N, Fujioka H, Sato Y, Arisawa M (2017)  Ligand-Free Suzuki–Miyaura Coupling Using Ruthenium(0) Nanoparticles and a Continuously Irradiating Microwave System Green Chem.. :19,  3357-3369 DOI:10.1039/C7GC01166K
Yoshikawa Y, Yamakawa M, Kobayashi T, Suzuki K, Arisawa M, Fujioka H (2017)  First Asymmetric Total Synthesis and Insight into the Structure of Laurenidificin Eur. J. Org. Chem.. :19,  2715-2718 DOI:10.1002/ejoc.201700321
Ohno S, Takamoto K, Fujioka H, Arisawa M (2017)  Cycloisomerization between Aryl Enol Ether and Silylalkynes under Ruthenium Hydride Catalysis: Synthesis of 2,3-Disubstituted Benzofurans Org. Lett.. 9 :19,  2422-2425 DOI:10.1021/acs.orglett.7b00985
Ikawa T, Masuda S, Nakajima H, Akai S (2017)  2-(Trimethylsilyl)phenyl Trimethylsilyl Ethers as Stable and Readily Accessible Benzyne Precursors J. Org. Chem.. 8 :82,  4242-4253 DOI:10.1021/acs.joc.7b00238
Ehara H, Yokoyama T, Shigematsu H, Yokoyama S, Shirouzu M, Sekine SI (2017)  Structure of the complete elongation complex of RNA polymerase II with basal factors Science. 6354 :357,  921-924 DOI:10.1126/science.aan8552 PMID:28775211 
Takeda H, Zhou W, Kido K, Suno R, Iwasaki T, Kobayashi T, Sawasaki T. (2017)  CP5 system, for simple and highly efficient protein purification with a C-terminal designed mini tag PLoS One. :12,  DOI:10.1371/journal.pone.0178246. PMID:28542437 
Yoda T, Hosokawa M, Takahashi K, Sakanashi C, Takeyama H, Kambara H. (2017)  Site-specific gene expression analysis using an automated tissue micro-dissection punching system. Sientific report. 1 :7,  4325- DOI:10.1038/s41598-017-04616-6.
Kato D., Osakabe A., Arimura Y., Mizukami Y., Horikoshi N., Saikusa K., Akashi S., Nishimura Y., Park S-Y., Nogami J., Maehara K., Ohkawa Y., Matsumoto A., Kono H., Inoue R., Sugiyama M., and Kurumizaka H. (2017)  Crystal structure of the overlapping dinucleosome composed of hexasome and octasome. Science. 356 :6334,  205-208 DOI:10.1126/science.aak9867 PMID:28408607 
Shirai A, Kawaguchi T, Shimojo H, Muramatsu D, Ishida-Yonetani M, Nishimura Y, Kimura H, Nakayama JI, Shinkai Y. (2017)  Impact of nucleic acid and methylated H3K9 binding activities of Suv39h1 on its heterochromatin assembly. eLife. 6 23517- DOI:10.7554/eLife.25317 PMID:28760201 
Okuda M., Nakazawa, Y., Guo C., Ogi T., and Nishimura Y.  (2017)  CommonTFIIH recruitment mechanism in global genome and transcription-coupled repair subpathways Nucleic Acids Res.. 45 :22,  13043-13055 DOI:10.1093/nar/gkx970 PMID:29069470 
Yoshitake Nishiyama, Satoshi Yokoshima, Tohru Fukuyama (2017)  Synthesis of Cardiopetaline via a Wagner_Meerwein Rearrangement without Preactivation of the Pivotal Hydroxy Group Org. Lett.. 19 5833-5835 DOI:10.1021/acs.orglett.7b02812
Shun Tanimura, Satoshi Yokoshima, Tohru Fukuyama (2017)  Total Synthesis of Huperzine Q Org. Lett.. 19 3684-3686 DOI:10.1021/acs.orglett.7b01633
Haruhiko Hattori, Satoshi Yokoshima, Tohru Fukuyama (2017)  Total Syntheses of Aurachins_A and B Total Syntheses of Aurachins_A and B Angew. Chem. Int. Ed.. 56 6980-6983 DOI:10.1002/anie.201702204
Ide T, Shimizu K, Kawato Y, Egami H, Hamashima Y. (2017)  α-Functionalization of TetrahHeterocyclesydroisoquinolines with Activated Alkyl Bromides under Photoredox Catalysis Heterocycles. :95,  738-747 DOI:0.3987/COM-16-S(S)73
Ota Y, Kawato Y, Egami H, Hamashima Y. (2017)  Enantioselective Allyl-, and Allenylboration of Aldehydes Catalyzed by Chiral Hydroxyl Carboxylic Acid Synlett. :28,  976-980 DOI:10.1055/s-0036-1588690
Ide T, Masuda S, Kawato Y, Egami H, Hamashima Y. (2017)  Benzylic C–H Trifluoromethylation via Photoenol Organic Letters. :19,  4452-4455 DOI:10.1021/acs.orglett.7b01971
Nagao Y, Hisanaga T, Egami H, Kawato Y, Hamashima Y. (2017)  Desymmetrization of Bisallylic Amides through Catalytic Enantioselective Bromocyclization with BINAP Monoxide Chemistry – A European Journal. :23,  16758-16762 DOI:10.1002/chem.201704847
Konishi H, Fukuda M, Ueda T, Manabe K.  (2017)  Palladium-Catalyzed External-CO-Free Reductive Carbonylation of Bromoarenes Organic Syntheses. 94 66-76 DOI:10.15227/orgsyn.094.0066
Yamaguchi M, Manabe K. (2017)  Three-Step Synthesis of 2,5,7-Trisubstituted Indoles from N-Acetyl-2,4,6-trichloroaniline Using Pd-Catalyzed Site-Selective Cross-Coupling Organic & Biomolecular Chemistry. 15 6645-6655 DOI:10.1039/C7OB01547J
Konishi H, Matsubara M, Mori K, Tokiwa T, Arulmozhiraja S, Yamamoto Y, Ishikawa Y, Hashimoto H, Shigeta Y, Tokiwa H, Manabe K.  (2017)  Mechanistic Insight into Weak-Base-Catalyzed Generation of Carbon Monoxide from Phenyl Formate and Its Application to Catalytic Carbonylation at Room Temperature without Use of External Carbon Monoxide Gas Advanced Synthesis & Catalysis. 359 3592-3601 DOI:10.1002/adsc.201700751
Yamaguchi M, Suzuki K, Sato Y, Manabe K. (2017)  Palladium-Catalyzed Direct C3-Selective Arylation of N-Unsubstituted Indoles with Aryl Chlorides and Triflates Organic Letters. 19 5388-5391 DOI:10.1021/acs.orglett.7b02669
Nakamura T., Oda T., Fukasawa Y., Tomii K. (2018)  Template-based quaternary structure prediction of proteins using enhanced profile-profile alignments Proteins. 86 274-282 DOI:10.1002/prot.25432 PMID:29178285 
Yamada K.D., Kunishima N., Matsuura Y., Nakai K., Naitow H., Fukasawa Y., Tomii K. (2017)  Designing better diffracting crystals of biotin carboxyl carrier protein from Pyrococcus horikoshii by a mutation based on the crystal-packing propensity of amino acids Acta crystallographica. Section D, Structural biology. 73 757-766 DOI:10.1107/S2059798317010932 PMID:28876239 
Oda T., Lim K., Tomii K. (2017)  Simple adjustment of the sequence weight algorithm remarkably enhances PSI-BLAST performance BMC Bioinformatics. 18 :1,  288- DOI:10.1186/s12859-017-1686-9 PMID:28578660 
Fukasawa Y., Oda T., Tomii K., Imai K. (2017)  Origin and Evolutionary Alteration of the Mitochondrial Import System in Eukaryotic Lineages Molecular biology and evolution. 34 :7,  1574-1586 DOI:10.1093/molbev/msx096 PMID:28369657 
MATSUI K, MAEGAWA Y, WAKI M, INAGAKI S, YAMAMOTO Y (2018)  Transfer hydrogenation of nitrogen heterocycles using recyclable rhodium catalyst immobilized on bipyridine-periodic mesoporous organosilica Catalysis Science & Technology. 8 :2,  534-539 DOI:10.1039/C7CY02167D
YAMAMOTO Y, MURAYAMA T, JIANG J, YASUI T, SHIBUYA M (2018)  The vinylogous Catellani reaction: A combined computational and experimental study Chemical Science. 9 :5,  1191-1199 DOI:10.1039/C7SC04265E
YAMAMOTO Y (2017)  Recent Topics of Cp*RuCl-Catalyzed Annulation Reactions Tetrahedron Letters. 58 :40,  3787-3794 DOI:10.1016/j.tetlet.2017.08.040
YAMAMOTO Y, OKUDE Y, MORI S, SHIBUYA M (2017)  Combined Experimental and Computational Study on Ruthenium(II)-Catalyzed Reactions of Diynes with Aldehydes and N,N-Dimethylformamide The Journal of Organic Chemistry. 82 :15,  7964-7973 DOI:10.1021/acs.joc.7b01229
FUJITA S, SHIBUYA M, YAMAMOTO Y (2017)  Intramolecular Hydroalkoxylation/Reduction and Hydroamination/Reduction of Unactivated Alkynes Using a Silane-Iodine Catalytic System Synthesis. 49 :18,  4199-4204 DOI:10.1055/s-0036-1588436
YAMAMOTO Y, NISHIMURA K, MORI S, SHIBUYA M (2017)  Assembly of a Benzo-Fused Bridged Ketone Scaffold from 1,5,10-Enediynes through One-Pot Ruthenium-Catalyzed Cyclization/Iodine-Mediated Oxidative Ring Expansion Angewandte Chemie International Edition. 56 :20,  5494-5497 DOI:10.1002/anie.201700493
Mizutani, H., Sugawara, H., Buckle, A.M., Sangawa, T., Miyazono, K., Ohtsuka, J., Nagata, K., Shijima, T., Nosaki, S., Xu, Y., Wang, D., Hu, X., Tanokura, M., Yura, K. (2017)  REFOLDdb: a new and sustainable gateway to experimental protocols for protein refolding BMC Structural Biology. 4 :17,  1-8 DOI:10.1186/s12900-017-0074-z PMID:28438161 

BINDSの支援を受けた研究成果(論文)

Kaneko N, Iwasaki T, Ito Y, Takeda H, Sawasaki T, Morikawa S, Nakano N, Kurata M, Masumoto J. (2017)  Applications of reconstituted inflammasomes in a cell-free system to drug discovery and elucidation of the pathogenesis of autoinflammatory diseases Inflamm Regen. :37,  9- DOI:10.1186/s41232-017-0040-y. PMID:29259708 
Krug SM, Hayaishi T, Iguchi D, Watari A, Takahashi A, Fromm M, Nagahama M, Takeda H, Okada Y, Sawasaki T, Doi T, Yagi K, Kondoh M (2017)  Angubindin-1, a novel paracellular absorption enhancer acting at the tricellular tight junction J Control Release.. :260,  1-11 DOI:10.1016/j.jconrel.2017.05.024. PMID:28528740 
Hashimoto Y, Shirakura K, Okada Y, Takeda H, Endo K, Tamura M, Watari A, Sadamura Y, Sawasaki T, Doi T, Yagi K, Kondoh M (2017)  Claudin-5-Binders Enhance Permeation of Solutes across the Blood-Brain Barrier in a Mammalian Model J Pharmacol Exp Ther. 2 :363,  275-283 DOI:10.1124/jpet.117.243014. PMID:28819070 
M. Senda, T. Senda (2018)  Anaerobic crystallization of proteins Biophysical Reviews.
Hayashi T, Senda M, Suzuki N, Nishikawa H, Ben C, Tang C, Nagase L, Inoue K, Senda T, Hatakeyama M. (2018)  Differential Mechanisms for SHP2 Binding and Activation Are Exploited by Geographically Distinct Helicobacter pylori CagA Oncoproteins. Cell Reports. 20 2876-2890
Tanaka T, Zhou Y, Ozawa T, Okizono R, Banba A, Yamamura T, Oga E, Muraguchi A, Sakurai, H (2018)  Ligand-activated epidermal growth factor receptor (EGFR) signaling governs endocytic trafficking of unliganded receptor monomers by non-canonical phosphorylation J Biol Chem. 7 :293,  2288-2301 DOI:10.1074/jbc.M117.811299 PMID:29255092 
Zaimoku Y, Takamatsu H, Hosomichi K, Ozawa T, Nakagawa N, Imi T, Maruyama H, Katagiri T., Kishi H, Tajima A, Muraguchi A, Kashiwase K, Nakao S (2017)  Identification of an HLA class I allele closely involved in the auto-antigen presentation in acquired aplastic anemia Blood. 21 :129,  2908-2916 DOI:10.1182/blood-2016-11-752378 PMID:28232583 
Kashima Y, Suzuki A, Liu Y, Hosokawa M, Matsunaga H, Shirai M, Arikawa K, Sugano S, Kohno T, Takeyama H, Tsuchihara K, Suzuki Y.  (2017)  Combinatory use of distinct single-cell RNA-seq analytical platforms reveals the heterogeneous transcriptome response. Sientific report. 1 :8,  3482- DOI:10.1038/s41598-018-21161-y.
Yoda T, Tanabe M, Tsuji T, Yoda T, Ishino S, Shirai T, Ishino Y, Takeyama H, Nishida H (2017)  Exonuclease processivity of archaeal replicative DNA polymerase in association with PCNA is expedited by mismatches in DNA. Scientific Reports. :7,  44582- DOI:DOI: 10.1038/srep44582 PMID:28300173 
Ueda H., Kurita J., Neyama H., Hirao Y., Kouji H., Mishina T., Kasai M., Nakano H., Yoshimori A., and Nishimura Y. (2017)  A mimetic of the mSin3-binding helix of NRSF/REST ameliorates abnormal pain behavior in chronic pain models. Bioorganic Med. Chem. Lett.. 27 :20,  4705-4709 DOI:10.1016/j.bmcl.2017.09.006. Epub 2017 Sep 7 PMID: 29069470 
Takii M, Kaneko KY, Akiyama K, Aoyagi Y, Tara Y, Asakawa T, Inai M, Kan T, Nemoto K, Ishikawa T.  (2017)  Insulinotropic and anti-apoptotic effects of nobiletin in INS-1D ß-cells Journal of Functional Foods. :30,  8-15 DOI:10.1016/j.jff.2016.12.037
Matsumaru T, Inai M, Ishigami K, Iwamatsu T, Maita H, Otsuguro S, Nomura T, Matsuda A, Ichikawa S, Sakaitani M, Shuto S, Maenaka K, Kan T. (2017)  Divergent synthesis of kinase inhibitor derivatives, leading to discovery of selective Gck inhibitors. Bioorganic and Medicinal Chemistry Letters. :27,  2144-2147 DOI:doi: 10.1016/j.bmcl.2017.03.055
Obara N, Watanabe T, Asakawa T, Kan T, Tanaka T. (2017)  Efficient synthesis of 3-amino-1,5-benzodiazepine-2-one derivatives. Synlett. :28,  1183-1186 DOI:10.1055/s-0036-1588954
Goto A, Yoshimura S, Nakao Y, Inai M, Asakawa T, Egi M, Hamashima Y, Kondo M, Kan T. (2017)  Synthetic Study on Pactamycin: Stereoselective Synthesis of the Cyclopentane Core Framework Organic Letters. :19,  3358-3361 DOI:10.1021/acs.orglett.7b01257
Nagasaka Y, Shintaku S, Matsumura K, Masuda A, Asakawa T, Inai M, Egi M, Hamashima H, Ishikawa Y, Kan T. (2017)  Total Synthesis of TAN1251C via Diastereoselective Construction of the Azaspiro Skeleton Organic Letters. :19,  3832-3842 DOI:10.1021/acs.orglett.7b01718.
Yoshioka N, Ouchi H, Kan T, Yoshida M, Nomura M. (2017)  Rapid LC-MS Determination of Acromelic Acids A and B, Toxic Constituents of the Mushroom Parale pistopsis acromelalga Food Hygiene and Safety Science. :58,  241-245 DOI:10.3358/shokueishi.58.241.
Shiga Y., Murata D., Sugimoto A., Oshima Y., Tada M., Ishii-Watabe A., Imai K., Tomii K., Takeuchi T., Kagaya S., Sato A. (2017)  Hinge-Deficient IgG1 Fc Fusion: Application to Human Lactoferrin Molecular pharmaceutics. 14 :9,  3025-3035 DOI:10.1021/acs.molpharmaceut.7b00221 PMID:28763236 
Nemoto K., Ramadan A., Arimura G.I., Imai K., Tomii K., Shinozaki K., Sawasaki T. (2017)  Tyrosine phosphorylation of the GARU E3 ubiquitin ligase promotes gibberellin signalling by preventing GID1 degradation Nature communications. 8 :1,  1004- DOI:10.1038/s41467-017-01005-5 PMID:29042542 
Nemoto K., Kagawa M., Nozawa A., Hasegawa Y., Hayashi M., Imai K., Tomii K., Sawasaki T. (2018)  Identification of new abscisic acid receptor agonists using a wheat cell-free based drug screening system Scientific reports. 8 :1,  4268- DOI:10.1038/s41598-018-22538-9 PMID:29523814 
Nakada-Tsukui K., Sekizuka T., Sato-Ebine E., Escueta-de Cadiz A., Ji D.D., Tomii K., Kuroda M., Nozaki T. (2018)  AIG1 affects in vitro and in vivo virulence in clinical isolates of Entamoeba histolytica PLoS pathogens. 14 :3,  DOI:10.1371/journal.ppat.1006882 PMID:29554130 
Soh Yamazaki, Yoshihiko Tanaka, Hiromitsu Araki, Akira Kohda, Fumiyuki Sanematsu, Tomoko Arasaki, Xuefeng Duan, Fumihito Miura, Takaharu Katagiri, Ryodai Shindo, Hiroyasu Nakano, Takashi Ito, Yoshinori Fukui, Shogo Endo, Hideki Sumimoto (2017)  The AP-1 transcription factor JunB is required for Th17 cell differentiation. Scientific Reports. 7 17402- DOI:10.1038/s41598-017-17597-3 PMID:29234109 
Wataru Fukasawa, Natsuki Mori, Masato Iwatsuki, Rei Hokari, Aki Ishiyama, Moe Nakajima, Takahito Ouchi, Kenichi Nonaka, Hiroki Kojima, Hirotaka Matsuo, Satoshi ?mura, Kazuro Shiomi (2018)  Tolyprolinol, a new dipeptide from Tolypocladium sp. FKI-7981 Antibiotics. DOI:10.1038/s41429-018-0041-3 PMID:29563600 
Akane Yamamichi, Fumiharu Ohka, Kosuke Aoki, Hiromichi Suzuki, Akira Kato, Masaki Hirano, Kazuya Motomura, Kuniaki Tanahashi, Lushun Chalise, Sachi Maeda, Toshihiko Wakabayashi, Yukinari Kato, Atsushi Natsume (2018)  Immunohistochemical ATRX expression is not a surrogate for 1p19q codeletion Brain Tumor PathologyEmail author. DOI:10.1007/s10014-018-0312-5 PMID:29550880 
Sonoko Kinjo, Masato Kiyomoto, Takashi Yamamoto, Kazuho Ikeo, Shunsuke Yaguchi (2018)  HpBase: A genome database of a sea urchin, Hemicentrotus pulcherrimus Development, growth & differentiation. DOI:10.1111/dgd.12429 PMID:29532461 
Sanae Tabata, Yu Kitago, Yuki Fujii, Emiko Mihara, Keiko Tamura-Kawakami, Naoko Norioka, Katsu Takahashi, Mika K.Kaneko, Yukinari Kato, Junichi Takagi (2018)  An anti-peptide monoclonal antibody recognizing the tobacco etch virus protease-cleavage sequence and its application to a tandem tagging system Protein expression and purification. DOI:10.1016/j.pep.2018.03.004 PMID:29550370 
Kentaro Shimizu, Wei Cao, Gul Saad, Michiru Shoji, and Tohru Terada (2018)  Comparative analysis of membrane protein structure databases BBA - Biomembranes (K.S. and W.C. are equal contribution.). 5 :1860,  1077-1091 DOI:10.1016/j.bbamem.2018.01.005
Setsu Nakae,Masafumi Shionyu,Tomohisa Ogawa,Tsuyoshi Shirai (2018)  Structures of jacalin-related lectin PPL3 regulating pearl shell biomineralization Proteins, structure, function, and bioinformatics. DOI:10.1002/prot.25491 PMID:29524263 
Shinji Yamada, Shunsuke Itai, Takuro Nakamura, Yao-Wen Chang, Hiroyuki Harada, Hiroyoshi Suzuki, Mika K. Kaneko, Yukinari Kato. (2017)  Establishment of H2Mab-119, an anti-human epidermal growth factor receptor 2 monoclonal antibody against pancreatic cancer. Monoclon. Antib. Immunodiagn. Immunother. 6 :36,  287-290 PMID:29172998 
Yao-Wen Chang, Shinji Yamada, Mika K. Kaneko, Yukinari Kato. (2017)  Epitope mapping of monoclonal antibody PMab-38 against dog podoplanin. Monoclon. Antib. Immunodiagn. Immunother. 6 :36,  291-295 PMID:29161183 
Toru Tamahara, Kyoko Ochiai, Akihiko Muto, Yukinari Kato, Nicolas Sax, Mitsuyo Matsumoto, Takeyoshi Koseki, Kazuhiko Igarashi (2017)  mTOR-Bach2 cascade controls cell cycle and class switch recombination during B cell differentiation. Moledular and Cellular Biology. 24 :37,  PMID:28993481 
Naoya Maekawa, Satoru Konnai, Satoshi Takagi, Yumiko Kagawa, Tomohiro Okagawa, Asami Nishimori, Ryoyo Ikebuchi, Yusuke Izumi, Tatsuya Deguchi, Chie Nakajima, Yukinari Kato, Keiichi Yamamoto, Hidetoshi Uemura, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi.  (2017)  A canine chimeric monoclonal antibody targeting PD-L1 and its clinical efficacy in canine oral malignant melanoma or undifferentiated sarcoma. Scientific Reports. 1 :7,  8951- PMID:28827658 
Shunsuke Itai, Yuki Fujii, Mika K. Kaneko, Shinji Yamada, Takuro Nakamura, Miyuki Yanaka, Noriko Saidoh, Yao-Wen Chang, Saori Handa, Maki Takahashi, Hiroyoshi Suzuki, Hiroyuki Harada, Yukinari Kato. (2017)  Establishment of CMab-43, a sensitive and specific anti-CD133 monoclonal antibody for immunohistochemistry. Monoclon. Antib. Immunodiagn. Immunother.. 5 :36,  231-235 PMID:28910211 
Shinji Yamada, Shunsuke Itai, Takuro Nakamura, Miyuki Yanaka, Noriko Saidoh, Yao-Wen Chang, Saori Handa, Hiroyuki Harada, Yumiko Kagawa, Osamu Ichii, Satoru Konnai, Mika K. Kaneko, Yukinari Kato. (2017)  PMab-52: Specific and sensitive monoclonal antibody against cat podoplanin for immunohistochemistry. Monoclon. Antib. Immunodiagn. Immunother.. 5 :36,  224-230 PMID:PMID:28737447 
Mika K. Kaneko, Akiko Kunita, Shinji Yamada, Takuro Nakamura, Miyuki Yanaka, Noriko Saidoh, Yao-Wen Chang, Saori Handa, Satoshi Ogasawara , Tomokazu Ohishi, Shinji Abe, Shunsuke Itai, Hiroyuki Harada, Manabu Kawada, Yasuhiko Nishioka, Masashi Fukayama, Yukinari Kato. (2017)  Antipodocalyxin antibody chPcMab-47 exerts antitumor activity in mouse xenograft models of colorectal adenocarcinomas. Monoclon. Antib. Immunodiagn. Immunother. . 4 :36,  157-162 PMID:PMID:28665782 
Takao Hashiguchi, Yoshinari Fukuda, Rei Matsuoka, Daisuke Kuroda, Marie Kubota, Yuta Shirogane, Shumpei Watanabe, Kouhei Tsumoto, Daisuke Kohda, Richard Karl, Plemper, Yusuke Yanagi (2018)  Structures of the prefusion form of measles virus fusion protein in complex with inhibitors Proceedings of the National Academy of Sciences - PNAS. 201718957- DOI:10.1073/pnas.1718957115 PMID:29463726 
Takayoshi Matsuda, Takuhiro Ito, Chie Takemoto, Kazushige Katsura, Mariko Ikeda, Motoaki Wakiyama, Mutsuko Kukimoto-Niino, Shigeyuki Yokoyama, Yoshikazu Kurosawa, Mikako Shirouzu (2018)  Cell-free synthesis of functional antibody fragments to provide a structural basis for antibody–antigen interaction PloS one. 13 :2,  193158- DOI:10.1371/journal.pone.0193158 PMID:29462206 
Takashi Matsunaga, Naoya Matsunaga, Naoki Kusunose, Eriko Ikeda, Hiroyuki Okazaki, Keisuke Kakimoto, Kengo Hamamura, Satoru Koyanagi, Shigehiro Ohdo (2018)  Angiotensin-II regulates dosing time-dependent intratumoral accumulation of macromolecular drug formulations via 24-h blood pressure rhythm in tumor-bearing mice Biochemical and Biophysical Research Communications. DOI:10.1016/j.bbrc.2017.11.162
Hiroaki Ohno, Shinsuke Inuki (2018)  Recent Progress in Palladium-Catalyzed Cascade Cyclizations for Natural Product Synthesis Synthesis. 4 :50,  700-710 DOI:10.1055/s-0036-1589165
Takashi Kurohara, Jiang Jiyue, Masatoshi Shibuya, Yoshihiko Yamamoto (2018)  Synthesis of Alkoxycarbonyldifluoromethyl-Substituted Semisquarates and Their Transformations Synthesis. :24,  DOI:10.1055/s-0036-1591887
Takashi Ikawa, Yuta Sumii, Shigeaki Masuda, Ding Wang, Yuto Emi, Akira Takagi, Shuji Akai (2018)  Synthesis of Optically Active 2,3-Disubstituted Indoline ­Derivatives through Cycloaddition Reactions between Benzynes and α,β-Unsaturated γ-Aminobutyronitriles Synlett . DOI:10.1055/s-0036-1591722
Akira R. Kinjo, Gert-Jan Bekker, Hiroshi Wako, Shigeru Endo, Yuko Tsuchiya, Hiromu Sato, Hafumi Nishi, Kengo Kinoshita, Hirofumi Suzuki, Takeshi Kawabata, Masashi Yokochi, Takeshi Iwata, Naohiro Kobayashi, Toshimichi Fujiwara, Genji Kurisu, Haruki Nakamura (2018)  New tools and functions in data-out activities at Protein Data Bank Japan (PDBj) Protein Science. 27 :1,  95-102 DOI:10.1002/pro.3273 PMID:28815765 
Atsushi Uematsu, Kohki Kido, Erika Manabe, Hiroyuki Takeda, Hirotaka Takahashi, Minoru Hayashi, Yuuki Imai, Tatsuya Sawasaki (2018)  DANFIN functions as an inhibitor of transcription factor NF-κB and potentiates the antitumor effect of bortezomib in multiple myeloma Biochemical and Biophysical Research Communications. 493 :3,  2289-2295 DOI:10.1016/j.bbrc.2017.12.142 PMID:29284118 
Yuu Miyazaki, Atsuhiko Ichimura, Shun Sato, Takuto Fujii, Shinya Oishi, Hideki Sakai, Hiroshi Takeshima (2018)  The natural flavonoid myricetin inhibits gastric H+, K+-ATPase European Journal of Pharmacology. 820 :5,  217-221 DOI:10.1016/j.ejphar.2017.12.042 PMID:29274333 
Shinji Yamada, Shunsuke Itai, Mika K. Kaneko, Yukinari Kato (2017)  PMab-48 Recognizes Dog Podoplanin of Lymphatic Endothelial Cells. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. DOI:10.1089/mab.2017.0053 PMID:29256716 
Nanao Suzuki, Yuuki Takamuku, Tomohiro Asakawa, Makoto Inai, Tomoya Hino, So Iwata, Toshiyuki Kan, Takeshi Murata (2018)  An efficient screening method for purifying and crystallizing membrane proteins using modified clear-native PAGE Analytical Biochemistry. DOI:10.1016/j.ab.2018.02.007 PMID:29432751 
Ryoichi Tashima, Keisuke Koga, Misuzu Sekine, Kensho Kanehisa, Yuta Kohro, Keiko Tominaga, Katsuyuki Matsushita, Hidetoshi Tozaki-Saitoh, Yugo Fukazawa, Kazuhide Inoue, Hiromu Yawo, Hidemasa Furue, Makoto Tsuda (2018)  Optogenetic Activation of Non-Nociceptive Aβ Fibers Induces Neuropathic Pain-like Sensory and Emotional Behaviors after Nerve Injury in Rats eNeuro. DOI:10.1523/ENEURO.0450-17.2018
Eiko Seki, Tatsuo Yanagisawa, Shigeyuki Yokoyama (2018)  Cell-Free Protein Synthesis for Multiple Site-Specific Incorporation of Noncanonical Amino Acids Using Cell Extracts from RF-1 Deletion E. coli Strains Noncanonical Amino Acids. 1728 49-65 DOI:10.1007/978-1-4939-7574-7_3 PMID:29404990 
Ryoko Tsukahara, Shinji Yamamoto, Keisuke Yoshikawa, Mari Gotoh, Tamotsu Tsukahara, Hiroyuki Neyama, Satoshi Ishii, Noriyuki Akahoshi, Keisuke Yanagida, Hayakazu Sumida, Masatake Araki, Kimi Araki, Ken-ichi Yamamura, Kimiko Murakami-Murofushi, Hiroshi Ueda (2018)  LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model Journal of Pharmacological Sciences. DOI:10.1016/j.jphs.2018.01.001
Asami Sugihara, Luan Cao Nguyen, Hossain Mohammad Shamim, Tetsushi Iida, Mai Nakase, Kaoru Takegawa, Mitsuhisa Senda, Shohei Jida, Masaru Ueno (2018)  Mutation in fission yeast phosphatidylinositol 4-kinase Pik1 is synthetically lethal with defect in telomere protection protein Pot1 Biochemical and Biophysical Research Communications. 496 :4,  1284-1290 DOI:10.1016/j.bbrc.2018.02.001
Sefan Asamitsu, Shunsuke Obata, Anh Tuân Phan, Kaori Hashiya, Toshikazu Bando, Hiroshi Sugiyama (2018)  Simultaneous binding of hybrid molecules constructed with dual DNA-binding components to a G-quadruplex and its proximal duplex CEMISTRY A Europian Journal. DOI:10.1002/chem.201705945 PMID:29380465 
Toby Passioura, Bhaskar Bhushan, Anthony Tumber, Akane Kawamura, Hiroaki Suga (2018)  Structure-activity studies of a macrocyclic peptide inhibitor of histone lysine demethylase 4A Bioorganic & Medicinal Chemistry. DOI:10.1016/j.bmc.2018.01.013
Kensuke Orihara, Fumiki Kawagishi, Satoshi Yokoshima, Tohru Fukuyama (2018)  Synthetic Studies of Haliclonin A: Construction of the 3-Azabicyclo[3.3.1]nonane Skeleton with a Bridge that Forms the 17-Membered Ring Synlett . 29 DOI:10.1055/s-0037-1609150
Akito Kawai, Keishi Yamasaki, Taisuke Enokida, Shuichi Miyamoto, Masaki Otagiri (2018)  Crystal structure analysis of human serum albumin complexed with sodium 4-phenylbutyrate Biochemistry and Biophysics Reports. 28 :13,  78-82 DOI:10.1016/j.bbrep.2018.01.006 PMID:29387812 
Shunsuke Itai, Shinji Yamada, Mika K. Kaneko, Hiroyuki Harada, Yukinari Kato (2017)  Immunohistochemical analysis using antipodocalyxin monoclonal antibody PcMab-47 demonstrates podocalyxin expression in oral squamous cell carcinomas. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy.. 36 :5,  220-223 DOI:10.1089/mab.2017.0030 PMID:28873000 
Tomoyo Mohri, Yusuke Ogura, Ryo Towada, Shigefumi Kuwahara (2017)  Enantioselective total synthesis of sacrolide A. Tetrahedron Letters.. 58 :42,  4011-4013 DOI:10.1016/j.tetlet.2017.09.017
Shunsuke Itai, Mika K. Kaneko, Yuki Fujii, Shinji Yamada, Takuro Nakamura, Miyuki Yanaka, Noriko Saidoh, Saori Handa, Yao-Wen Chang, Hiroyoshi Suzuki, Hiroyuki Harada, Yukinari Kato (2017)  Development of EMab-51, a sensitive and specific anti-epidermal growth factor receptor monoclonal antibody in flow cytometry, western blot, and immunohistochemistry. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy.. 36 :5,  214-219 DOI:10.1089/mab.2017.0028 PMID:28891752 
Yuko Ehara, Osamu Yamamoto, Kenjiro Kosaki, Yuichi Yoshida (2017)  Natural course and characteristics of cutaneous neurofibromas in neurofibromatosis 1. Journal of Dermstology. in press. 45 :1,  53-57 DOI:10.1111/1346-8138.14025 PMID:28891076 
Masataka Enoki, Saki Shinto, Yuta Matsuoka, Ayasa Otsuka, Sachiko Kaidzu, Masaki Tanito, Takahiro Shibata, Koji Uchida, Akihiro Ohira, Mayumi Yamato, Ken-ichi Yamada (2017)  Lipid radicals cause light-induced retinal degeneration . Chemical Communications.. 53 :79,  10922-10925 DOI:10.1039/C7CC03387G PMID:28930310 
Yuka Kobayashi, Tomoshi Kameda, Masaru Hoshino, Nobutaka Fujii, Hiroaki Ohno, Shinya Oishi (2017)  Fe(II)-complexation of tripodal hexapeptide ligands with three bidentate triazolylpyridines: induction of metal-centred chirality by peptide macrocyclization. Dalton Transactions.. 46 :40,  13673-13676 DOI:10.1039/C7DT02739G PMID:28951936 
Takao Arimori, Yu Kitago, Masataka Umitsu, Yuki Fujii, Ryoko Asaki, Keiko Tamura-Kawakami, Junichi Takagi (2017)  Fv-clasp: An artificially designed small antibody fragment with improved production compatibility, stability, and crystallizability. Structure.. 25 :10,  1611-1622 DOI:10.1016/j.str.2017.08.011 PMID:28919443 
Koun Onodera, Shumpei Baba, Akira Murakami, Tadashi Uemura, Tadao Usui (2017)  Small conductance Ca2+-activated K+ channels induce the firing pause periods during the activation of Drosophila nociceptive neurons. Elife.. 6 29754- DOI:10.7554/eLife.29754 PMID:29035200 
Hiroshi Kaneko,Takehide Katoh, Ikuo Hirano, Atsushi Hasegawa, Tadayuki Tsujita, Masayuki Yamamoto, Ritsuko Shimizu (2017)  Induction of erythropoietin gene expression in epithelial cells by chemicals identified in GATA inhibitor screenings. Genes to Cell.. 22 :11,  939-952 DOI:10.1111/gtc.12537 PMID:29044949 
Atsushi Furukawa, Kosuke Kakita, Tomoki Yamada, Mikihiro Ishizuka, Jiro Sakamoto, Nanao Hatori, Naoyoshi Maeda, Fumina Ohsaka, Takashi Saitoh Takao Nomura, Kimiko Kuroki, Hisanori Nambu, Hisashi Arase, Shigeki Matsunaga, Masahiro Anada, Toyoyuki Ose, Shunichi Hashimoto, Katsumi Maenaka (2017)  Structural and thermodynamic analyses reveal critical features of glycopeptide recognition by the human PILR-α immune cell receptor. Journal of Bological Chemistry. in press. 292 :51,  21128-21136 DOI:10.1074/jbc.M117.799239 PMID:29046357 
Mizuki Nakamura, Sayaka Shibata, Toshihide Yamasaki, Megumi Ueno, Ikuo Nakanishi, Ken-ichiro Matsumoto, Tadashi Kamada, Ken-ichi Yamada, Ichio Aoki (2017)  Feasibility of magnetic resonance redox imaging at low magnetic field: comparision at 1T and 7T. Amerincan Journal of Translational Research. 9 :10,  4481-4491 PMID:29118910 
Yuma Ishida, Yuka Okamoto, Yuta Matsuoka, Arisa Tada, Jindaporn Janprasit, Mayumi Yamato, Noppawan Phumala Morales, Ken-Ichi Yamada (2017)  Detection and inhibition of lipid-derived radicals in low-density lipoprotein. Free Radical Biology and Medicine.. 113 487-493 DOI:10.1016/j.freeradbiomed.2017.10.388 PMID:29107744 
Katsunori Takahashi, Haruhisa Kikuchi, Van Hai Nguyen, Yoshiteru Oshima, Hirotaka Ishigaki, Junko Nakajima-Shimada, Yuzuru Kubohara (2017)  Biological activities of novel derivatives of differentiation-inducing factor 3 from Dictyostelium discoideum. Biological and Pharmaceutical Bulletin.. 40 :11,  1941-1947 DOI:10.1248/bpb.b17-00484 PMID:29093342 
Shuichi Mori, Ryohei Takagaki, Shinya Fujii, Ko Urushibara, Aya Tanatani, Hiroyuki Kagechika (2017)  Novel non-steroidal progesterone receptor ligands based on m-carborane containing a secondary alcohol: Effect of chirality on ligand activity. Chemical and Pharmaceutical Bulletin.. 65 :11,  1051-1057 DOI:10.1248/cpb.c17-00544 PMID:29093292 
Itai Shunsuke, Yamada Shinji, Kaneko Mika K., Harada Hiroyuki, Kagawa Yumiko, Konnai Satoru, Kato Yukinari (2017)  Expression of cat podoplanin in feline squamous cell carcinomas. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. in press. 36 :6,  243-250 DOI:10.1089/mab.2017.0046 PMID:29090969 
Itai Shunsuke, Yamada Shinji, Kaneko Mika K., Chang Yao-Wen, Harada Hiroyuki, Kato Yukinari (2017)  Establishment of EMab-134, a sensitive and specific anti-epidermal growth factor receptor monoclonal antibody for detecting squamous cell carcinoma cells of the oral cavity. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. in press. 36 :6,  272-281 DOI:10.1089/mab.2017.0042 PMID:29090976 
Masako Koyama, Hitoshi Kurumizaka (2017)  Structural diversity of the nucleosome. Journal of Biochemistry. in press. 163 :2,  85-95 DOI:10.1093/jb/mvx081 PMID:29161414 
Zuben P. Brown, Takao Arimori, Kenji Iwasaki, Junichi Takagi (2017)  Development of a new protein labeling system to map subunits and domains of macromolecular complexes for electron microscopy. Journal of Structural Biology. in press. DOI:10.1016/j.jsb.2017.11.006 PMID:29170031 
Gengo Kashiwazaki, Rina Maeda, Takashi Kawase, Kaori Hashiya, Toshikazu Bando, Hiroshi Sugiyama (2017)  Evaluation of alkylating pyrrole-imidazole polyamide conjugates by a novel method for high-throughput sequencer. Bioorganic & Medicinal Chemistry.. 26 :1,  1-7 DOI:10.1016/j.bmc.2017.08.057 PMID:29224995 
Yuri Sakai, Atsushi Kawaguchi, Kyosuke Nagata, Takatsugu Hirokawa (2017)  Binding pathway analysis of influenza virus M2 channel blockers by metadynamics simulation. Microbiology and Immunology. in press. 62 :1,  34-43 DOI:10.1111/1348-0421.12561 PMID:29210473 
Shohei Mori, Kunihiko Morihiro, Takumi Okuda, Yuuya Kasahara, Satoshi Obika (2017)  Hydrogen peroxide-triggered gene silencing in mammalian cells through boronated antisense oligonucleotides. Royal Society of Chemistry. in press.. 9 :5,  1112-1118 DOI:10.1039/C7SC04318J
Toshimune Nomura, Satoshi Yokoshima, Tohru Fukuyama (2017)  Total synthesis of huperzine R. Organic letters. in press. 20 :1,  119-121 DOI:10.1021/acs.orglett.7b03555 PMID:29219324 
Fumihito_Miura, Takashi_Ito (2017)  Post-bisulfite adaptor tagging for PCR-free whole-genome bisulfite sequencing. DNA Methylation Protocols.. 1708 123-136 DOI:10.1007/978-1-4939-7481-8_7 PMID:29224142