成果

高度化技術の応用と実際に創薬等先端技術支援基盤プラットフォームの高度化技術を使用した研究成果を紹介しています。

支援技術に関する成果

BINDSの支援を受けた研究成果

Hiroaki Ohno, Shinsuke Inuki (2018)  Recent Progress in Palladium-Catalyzed Cascade Cyclizations for Natural Product Synthesis Synthesis. 4 :50,  700-710 DOI:10.1055/s-0036-1589165
Takashi Kurohara, Jiang Jiyue, Masatoshi Shibuya, Yoshihiko Yamamoto (2018)  Synthesis of Alkoxycarbonyldifluoromethyl-Substituted Semisquarates and Their Transformations Synthesis. :24,  DOI:10.1055/s-0036-1591887
Takashi Ikawa, Yuta Sumii, Shigeaki Masuda, Ding Wang, Yuto Emi, Akira Takagi, Shuji Akai (2018)  Synthesis of Optically Active 2,3-Disubstituted Indoline ­Derivatives through Cycloaddition Reactions between Benzynes and α,β-Unsaturated γ-Aminobutyronitriles Synlett . DOI:10.1055/s-0036-1591722
Akira R. Kinjo, Gert-Jan Bekker, Hiroshi Wako, Shigeru Endo, Yuko Tsuchiya, Hiromu Sato, Hafumi Nishi, Kengo Kinoshita, Hirofumi Suzuki, Takeshi Kawabata, Masashi Yokochi, Takeshi Iwata, Naohiro Kobayashi, Toshimichi Fujiwara, Genji Kurisu, Haruki Nakamura (2018)  New tools and functions in data-out activities at Protein Data Bank Japan (PDBj) Protein Science. 27 :1,  95-102 DOI:10.1002/pro.3273 PMID:28815765 
Atsushi Uematsu, Kohki Kido, Erika Manabe, Hiroyuki Takeda, Hirotaka Takahashi, Minoru Hayashi, Yuuki Imai, Tatsuya Sawasaki (2018)  DANFIN functions as an inhibitor of transcription factor NF-κB and potentiates the antitumor effect of bortezomib in multiple myeloma Biochemical and Biophysical Research Communications. 493 :3,  2289-2295 DOI:10.1016/j.bbrc.2017.12.142 PMID:29284118 
Yuu Miyazaki, Atsuhiko Ichimura, Shun Sato, Takuto Fujii, Shinya Oishi, Hideki Sakai, Hiroshi Takeshima (2018)  The natural flavonoid myricetin inhibits gastric H+, K+-ATPase European Journal of Pharmacology. 820 :5,  217-221 DOI:10.1016/j.ejphar.2017.12.042 PMID:29274333 
Shinji Yamada, Shunsuke Itai, Mika K. Kaneko, Yukinari Kato (2017)  PMab-48 Recognizes Dog Podoplanin of Lymphatic Endothelial Cells. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. DOI:10.1089/mab.2017.0053 PMID:29256716 
Nanao Suzuki, Yuuki Takamuku, Tomohiro Asakawa, Makoto Inai, Tomoya Hino, So Iwata, Toshiyuki Kan, Takeshi Murata (2018)  An efficient screening method for purifying and crystallizing membrane proteins using modified clear-native PAGE Analytical Biochemistry. DOI:10.1016/j.ab.2018.02.007 PMID:29432751 
Ryoichi Tashima, Keisuke Koga, Misuzu Sekine, Kensho Kanehisa, Yuta Kohro, Keiko Tominaga, Katsuyuki Matsushita, Hidetoshi Tozaki-Saitoh, Yugo Fukazawa, Kazuhide Inoue, Hiromu Yawo, Hidemasa Furue, Makoto Tsuda (2018)  Optogenetic Activation of Non-Nociceptive Aβ Fibers Induces Neuropathic Pain-like Sensory and Emotional Behaviors after Nerve Injury in Rats eNeuro. DOI:10.1523/ENEURO.0450-17.2018
Eiko Seki, Tatsuo Yanagisawa, Shigeyuki Yokoyama (2018)  Cell-Free Protein Synthesis for Multiple Site-Specific Incorporation of Noncanonical Amino Acids Using Cell Extracts from RF-1 Deletion E. coli Strains Noncanonical Amino Acids. 1728 49-65 DOI:10.1007/978-1-4939-7574-7_3 PMID:29404990 
Ryoko Tsukahara, Shinji Yamamoto, Keisuke Yoshikawa, Mari Gotoh, Tamotsu Tsukahara, Hiroyuki Neyama, Satoshi Ishii, Noriyuki Akahoshi, Keisuke Yanagida, Hayakazu Sumida, Masatake Araki, Kimi Araki, Ken-ichi Yamamura, Kimiko Murakami-Murofushi, Hiroshi Ueda (2018)  LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model Journal of Pharmacological Sciences. DOI:10.1016/j.jphs.2018.01.001
Asami Sugihara, Luan Cao Nguyen, Hossain Mohammad Shamim, Tetsushi Iida, Mai Nakase, Kaoru Takegawa, Mitsuhisa Senda, Shohei Jida, Masaru Ueno (2018)  Mutation in fission yeast phosphatidylinositol 4-kinase Pik1 is synthetically lethal with defect in telomere protection protein Pot1 Biochemical and Biophysical Research Communications. 496 :4,  1284-1290 DOI:10.1016/j.bbrc.2018.02.001
Sefan Asamitsu, Shunsuke Obata, Anh Tuân Phan, Kaori Hashiya, Toshikazu Bando, Hiroshi Sugiyama (2018)  Simultaneous binding of hybrid molecules constructed with dual DNA-binding components to a G-quadruplex and its proximal duplex CEMISTRY A Europian Journal. DOI:10.1002/chem.201705945 PMID:29380465 
Toby Passioura, Bhaskar Bhushan, Anthony Tumber, Akane Kawamura, Hiroaki Suga (2018)  Structure-activity studies of a macrocyclic peptide inhibitor of histone lysine demethylase 4A Bioorganic & Medicinal Chemistry. DOI:10.1016/j.bmc.2018.01.013
Kensuke Orihara, Fumiki Kawagishi, Satoshi Yokoshima, Tohru Fukuyama (2018)  Synthetic Studies of Haliclonin A: Construction of the 3-Azabicyclo[3.3.1]nonane Skeleton with a Bridge that Forms the 17-Membered Ring Synlett . 29 DOI:10.1055/s-0037-1609150
Akito Kawai, Keishi Yamasaki, Taisuke Enokida, Shuichi Miyamoto, Masaki Otagiri (2018)  Crystal structure analysis of human serum albumin complexed with sodium 4-phenylbutyrate Biochemistry and Biophysics Reports. 28 :13,  78-82 DOI:10.1016/j.bbrep.2018.01.006 PMID:29387812 
Shunsuke Itai, Shinji Yamada, Mika K. Kaneko, Hiroyuki Harada, Yukinari Kato (2017)  Immunohistochemical analysis using antipodocalyxin monoclonal antibody PcMab-47 demonstrates podocalyxin expression in oral squamous cell carcinomas. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy.. 36 :5,  220-223 DOI:10.1089/mab.2017.0030 PMID:28873000 
Tomoyo Mohri, Yusuke Ogura, Ryo Towada, Shigefumi Kuwahara (2017)  Enantioselective total synthesis of sacrolide A. Tetrahedron Letters.. 58 :42,  4011-4013 DOI:10.1016/j.tetlet.2017.09.017
Shunsuke Itai, Mika K. Kaneko, Yuki Fujii, Shinji Yamada, Takuro Nakamura, Miyuki Yanaka, Noriko Saidoh, Saori Handa, Yao-Wen Chang, Hiroyoshi Suzuki, Hiroyuki Harada, Yukinari Kato (2017)  Development of EMab-51, a sensitive and specific anti-epidermal growth factor receptor monoclonal antibody in flow cytometry, western blot, and immunohistochemistry. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy.. 36 :5,  214-219 DOI:10.1089/mab.2017.0028 PMID:28891752 
Yuko Ehara, Osamu Yamamoto, Kenjiro Kosaki, Yuichi Yoshida (2017)  Natural course and characteristics of cutaneous neurofibromas in neurofibromatosis 1. Journal of Dermstology. in press. 45 :1,  53-57 DOI:10.1111/1346-8138.14025 PMID:28891076 
Masataka Enoki, Saki Shinto, Yuta Matsuoka, Ayasa Otsuka, Sachiko Kaidzu, Masaki Tanito, Takahiro Shibata, Koji Uchida, Akihiro Ohira, Mayumi Yamato, Ken-ichi Yamada (2017)  Lipid radicals cause light-induced retinal degeneration . Chemical Communications.. 53 :79,  10922-10925 DOI:10.1039/C7CC03387G PMID:28930310 
Yuka Kobayashi, Tomoshi Kameda, Masaru Hoshino, Nobutaka Fujii, Hiroaki Ohno, Shinya Oishi (2017)  Fe(II)-complexation of tripodal hexapeptide ligands with three bidentate triazolylpyridines: induction of metal-centred chirality by peptide macrocyclization. Dalton Transactions.. 46 :40,  13673-13676 DOI:10.1039/C7DT02739G PMID:28951936 
Takao Arimori, Yu Kitago, Masataka Umitsu, Yuki Fujii, Ryoko Asaki, Keiko Tamura-Kawakami, Junichi Takagi (2017)  Fv-clasp: An artificially designed small antibody fragment with improved production compatibility, stability, and crystallizability. Structure.. 25 :10,  1611-1622 DOI:10.1016/j.str.2017.08.011 PMID:28919443 
Koun Onodera, Shumpei Baba, Akira Murakami, Tadashi Uemura, Tadao Usui (2017)  Small conductance Ca2+-activated K+ channels induce the firing pause periods during the activation of Drosophila nociceptive neurons. Elife.. 6 29754- DOI:10.7554/eLife.29754 PMID:29035200 
Hiroshi Kaneko,Takehide Katoh, Ikuo Hirano, Atsushi Hasegawa, Tadayuki Tsujita, Masayuki Yamamoto, Ritsuko Shimizu (2017)  Induction of erythropoietin gene expression in epithelial cells by chemicals identified in GATA inhibitor screenings. Genes to Cell.. 22 :11,  939-952 DOI:10.1111/gtc.12537 PMID:29044949 
Atsushi Furukawa, Kosuke Kakita, Tomoki Yamada, Mikihiro Ishizuka, Jiro Sakamoto, Nanao Hatori, Naoyoshi Maeda, Fumina Ohsaka, Takashi Saitoh Takao Nomura, Kimiko Kuroki, Hisanori Nambu, Hisashi Arase, Shigeki Matsunaga, Masahiro Anada, Toyoyuki Ose, Shunichi Hashimoto, Katsumi Maenaka (2017)  Structural and thermodynamic analyses reveal critical features of glycopeptide recognition by the human PILR-α immune cell receptor. Journal of Bological Chemistry. in press. 292 :51,  21128-21136 DOI:10.1074/jbc.M117.799239 PMID:29046357 
Mizuki Nakamura, Sayaka Shibata, Toshihide Yamasaki, Megumi Ueno, Ikuo Nakanishi, Ken-ichiro Matsumoto, Tadashi Kamada, Ken-ichi Yamada, Ichio Aoki (2017)  Feasibility of magnetic resonance redox imaging at low magnetic field: comparision at 1T and 7T. Amerincan Journal of Translational Research. 9 :10,  4481-4491 PMID:29118910 
Yuma Ishida, Yuka Okamoto, Yuta Matsuoka, Arisa Tada, Jindaporn Janprasit, Mayumi Yamato, Noppawan Phumala Morales, Ken-Ichi Yamada (2017)  Detection and inhibition of lipid-derived radicals in low-density lipoprotein. Free Radical Biology and Medicine.. 113 487-493 DOI:10.1016/j.freeradbiomed.2017.10.388 PMID:29107744 
Katsunori Takahashi, Haruhisa Kikuchi, Van Hai Nguyen, Yoshiteru Oshima, Hirotaka Ishigaki, Junko Nakajima-Shimada, Yuzuru Kubohara (2017)  Biological activities of novel derivatives of differentiation-inducing factor 3 from Dictyostelium discoideum. Biological and Pharmaceutical Bulletin.. 40 :11,  1941-1947 DOI:10.1248/bpb.b17-00484 PMID:29093342 
Shuichi Mori, Ryohei Takagaki, Shinya Fujii, Ko Urushibara, Aya Tanatani, Hiroyuki Kagechika (2017)  Novel non-steroidal progesterone receptor ligands based on m-carborane containing a secondary alcohol: Effect of chirality on ligand activity. Chemical and Pharmaceutical Bulletin.. 65 :11,  1051-1057 DOI:10.1248/cpb.c17-00544 PMID:29093292 
Itai Shunsuke, Yamada Shinji, Kaneko Mika K., Harada Hiroyuki, Kagawa Yumiko, Konnai Satoru, Kato Yukinari (2017)  Expression of cat podoplanin in feline squamous cell carcinomas. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. in press. 36 :6,  243-250 DOI:10.1089/mab.2017.0046 PMID:29090969 
Itai Shunsuke, Yamada Shinji, Kaneko Mika K., Chang Yao-Wen, Harada Hiroyuki, Kato Yukinari (2017)  Establishment of EMab-134, a sensitive and specific anti-epidermal growth factor receptor monoclonal antibody for detecting squamous cell carcinoma cells of the oral cavity. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. in press. 36 :6,  272-281 DOI:10.1089/mab.2017.0042 PMID:29090976 
Masako Koyama, Hitoshi Kurumizaka (2017)  Structural diversity of the nucleosome. Journal of Biochemistry. in press. 163 :2,  85-95 DOI:10.1093/jb/mvx081 PMID:29161414 
Zuben P. Brown, Takao Arimori, Kenji Iwasaki, Junichi Takagi (2017)  Development of a new protein labeling system to map subunits and domains of macromolecular complexes for electron microscopy. Journal of Structural Biology. in press. DOI:10.1016/j.jsb.2017.11.006 PMID:29170031 
Gengo Kashiwazaki, Rina Maeda, Takashi Kawase, Kaori Hashiya, Toshikazu Bando, Hiroshi Sugiyama (2017)  Evaluation of alkylating pyrrole-imidazole polyamide conjugates by a novel method for high-throughput sequencer. Bioorganic & Medicinal Chemistry.. 26 :1,  1-7 DOI:10.1016/j.bmc.2017.08.057 PMID:29224995 
Yuri Sakai, Atsushi Kawaguchi, Kyosuke Nagata, Takatsugu Hirokawa (2017)  Binding pathway analysis of influenza virus M2 channel blockers by metadynamics simulation. Microbiology and Immunology. in press. 62 :1,  34-43 DOI:10.1111/1348-0421.12561 PMID:29210473 
Shohei Mori, Kunihiko Morihiro, Takumi Okuda, Yuuya Kasahara, Satoshi Obika (2017)  Hydrogen peroxide-triggered gene silencing in mammalian cells through boronated antisense oligonucleotides. Royal Society of Chemistry. in press.. 9 :5,  1112-1118 DOI:10.1039/C7SC04318J
Toshimune Nomura, Satoshi Yokoshima, Tohru Fukuyama (2017)  Total synthesis of huperzine R. Organic letters. in press. 20 :1,  119-121 DOI:10.1021/acs.orglett.7b03555 PMID:29219324 
Fumihito_Miura, Takashi_Ito (2017)  Post-bisulfite adaptor tagging for PCR-free whole-genome bisulfite sequencing. DNA Methylation Protocols.. 1708 123-136 DOI:10.1007/978-1-4939-7481-8_7 PMID:29224142 

PDISの支援を受けた研究成果

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公開特許一覧表

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