成果

創薬等先端技術支援基盤プラットフォーム(BINDS)の支援実施者による支援技術に関する研究成果と、BINDSの支援を受けた外部研究者の研究成果(論文)を紹介しています。

支援技術に関する研究成果(論文)

Murayama T, Ogawa H, Kurebayashi N, Ohno S, Horie M, Sakurai T (2018)  A tryptophan residue in the caffeine-binding site of the ryanodine receptor regulates Ca2+ sensitivity Communications Biology. 1 98- DOI:10.1038/s42003-018-0103-x
Murayama, T, Kurebayashi N, Ikegami-Yuasa M, Mori S, Suzuki Y, Akima R, Ogawa H, Suzuki J, Kanemaru K, Oyamada H, Kiuchi Y, Iino M, Kagechika H, Sakurai T (2018)  Efficient high-throughput screening by ER Ca2+ measurement to identify inhibitors of ryanodine receptor Ca2+-release channels. Molecular Pharmacology. 94 722-730 DOI:10.1124/mol.117.111468 PMID:29674523 
Hijikata A, Tsuji T, Shionyu M, Shirai T (2017)  Decoding disease-causing mechanisms of missense mutations from supramolecular structures. Scientific Reports. :7,  8541- DOI:DOI:10.1038/s41598-017-08902-1 PMID:28819267 
Nagao Y., Hisanaga T., Utsumi T., Egami H., Kawato Y., Hamashima Y.  (2018)  Enantioselective Synthesis of Nelfinavir via Asymmetric Bromocyclization of Bisallylic Amide The Journal of Organic Chemistry. DOI:10.1021/acs.joc.8b00039.
Egami H., Niwa T., Sato H., Hotta R., Rouno T., Kawato Y., Hamashima Y. (2018)  Dianionic Phase-Transfer Catalyst for Asymmetric Fluoro-cyclization Journal of the American Chemical Society. :140,  2785-2788 DOI:1-.1021/jacs.7b13690
Egami H., Masuda S., Kawato Y., Hamashima Y. (2018)  Photofluorination of Aliphatic C–H Bonds Promoted by the Phthalimide Group Organic Letters. :20,  1367-1370 DOI:10.1021/acs.orglett.8b00133
Konishi H, Tanaka H, Manabe K.  (2017)  Pd-Catalyzed Selective Synthesis of Cyclic Sulfonamides and Sulfinamides Using K2S2O5 as a Sulfur Dioxide Surrogate Organic Letters. 19 1578-1581 DOI:10.1021/acs.orglett.7b00402
SHIBUYA M, OKAMOTO M, FUJITA S, ABE M, YAMAMOTO Y (2018)  Boron-Catalyzed Double Hydrofunctionalization Reactions of Unactivated Alkynes ACS Catalysis. 8 4189-4193 DOI:10.1021/acscatal.8b00955

BINDSの支援を受けた研究成果

Keisuke Yoshida, Masafumi Muratani, Hiromitsu Araki, Fumihito Miura, Takehiro Suzuki, Naoshi Dohmae, Yuki Katou, Katsuhiko Shirahige, Takashi Ito, Shunsuke Ishii  (2018)  Mapping of histone-binding sites in histone replacement-completed spermatozoa. Nature Communications. 9 3885- DOI:10.1038/s41467-018-06243-9 PMID:30250204 
Katsuyama Y., Sato, Y., Sugai, Y., Higashiyama, Y., Senda, M., Senda, T., Ohnishi, Y. (2018)  Crystal structure of the nitrosuccinate lyase CreD in complex with fumarate provides insights into the catalytic mechanism for nitrous acid elimination. The FEBS Journal. 285 1540-1555 DOI:10.1111/febs.14380.
Koentjoro, M.P., Adachi, N., Senda, M., Ogawa, N. and Senda, T. (2018)  Crystal structure of the DNA–binding domain of the LysR–type transcriptional regulator CbnR in complex with a DNA fragment of the recognition binding site in the promoter region FEBS Journal. 5 :285,  977-989 DOI:10.1111/febs.14380
Y. Nakashima, T. Mori, H. Nakamura, T. Awakawa, S. Hoshino, M. Senda, T. Senda, I. Abe (2018)  Structure, function and engineering of multifunctional non-heme iron dependent oxygenases in fungal meroterpenoid biosynthesis Nature Communications. 9 104- DOI:10.1038/s41467-017-02371-w
Ozawa T, Masaki H, Takasaki T, Aoyama I, Yumisashi T, Yamanaka A, Konishi E, Ohnuki Y, Muraguchi A, Kishi H (2018)  Human monoclonal antibodies against West Nile virus from Japanese encephalitis-vaccinated volunteers Antiviral Res. :154,  58-65 DOI:10.1016/j.antiviral.2018.04.011 PMID:29665373 
Natsuko Hama, Yasushi Totoki, Fumihito Miura, Kenji Tatsuno, Mihoko Saito-Adachi, Hiromi Nakamura, Yasuhito Arai, Fumie Hosoda, Tomoko Urushidate, Shoko Ohashi, Wakako Mukai, Nobuyoshi Hiraoka, Hiroyuki Aburatani, Takashi Ito, Tatsuhiro Shibata (2018)  Epigenetic landscape influences the liver cancer genome architecture Nature Communications. 9 1643- DOI:10.1038/s41467-018-03999-y PMID:29691395 
K. Nozawa-Kumada, E. Abe, S. Ito, M. Shigeno, Y. Kondo (2018)  Super Electron Donor-mediated Reductive Transformation of Nitrobenzenes: A Novel Strategy to Synthesize Azobenzenes and Phenazines Organic & Biomolecular Chemistry. DOI:10.1039/C8OB00271A PMID:29634065 
Hiroto Sagara, Masaki Kanakogi, Yuki Tara, Hitoshi Ouchi, Junko Kimura, Yukiko Kaneko, Makoto Inai, Tomohiro Asakawa, Tomohisa Ishikawa, Toshiyuki Kan (2018)  Concise synthesis of polymethoxyflavone sudachitin and its derivatives, and biological evaluations Tetrahedron Letters. :59,  1816-1818 DOI:10.1016/j.tetlet.2018.03.064
Yohei Miyanoiri, Atsushi Hijikata, Yuuki Nishino, Mizuki Gohara, Yasuhiro Onoue, Seiji Kojima, Chojiro Kojima, Tsuyoshi Shirai, Masatsune Kainosho, Michio Homma. (2018)  Structural and functional analysis of the C-terminal region of FliG, an essential motor component of vibrio Na+-driven flagella. Structure. 10 :25,  1540-1548 PMID:28919442 
Shunsuke Itai, Yuki Fujii, Mika K. Kaneko, Shinji Yamada, Takuro Nakamura, Miyuki Yanaka, Noriko Saidoh, Yao-Wen Chang, Saori Handa, Maki Takahashi, Hiroyoshi Suzuki, Hiroyuki Harada, Yukinari Kato. (2017)  H2Mab-77 is a Sensitive and Specific Anti-HER2 Monoclonal Antibody Against Breast Cancer Monoclon. Antib. Immunodiagn. Immunother.. 4 :36,  143-148 PMID:PMID:28700270