成果

創薬等先端技術支援基盤プラットフォーム(BINDS)の実施者による研究支援と研究高度化の成果として輩出されたデータベース、 ツール、論文および特許を紹介します。

開発されたデータベースやツール

ケミカルシーズ・リード 探索ユニット

インシリコユニット

プラットフォーム機能最適化ユニット

BINDS支援技術に関する研究成果(論文)

BINDSの支援を受けた研究成果(論文)

Kenta Ujifuku, Takashi Fujimoto, Kei Sato, Yoichi Morofuji, Hideki Muto, Hiroshi Masumoto, Shinsuke Nakagawa, Masami Niwa, Takayuki Matsuo (2020)  Exploration of Pericyte‑Derived Factors Implicated in Lung Cancer Brain Metastasis Protection: A Pilot Messenger RNA Sequencing Using the Blood–Brain Barrier In Vitro Model Cellular and Molecular Neurobiology. DOI:10.1007/s10571-020-00988-y
MaoIsono, WakakoFuruyama, MakotoKuroda, TatsunariKondoh, ManabuIgarashi, MasahiroKajihara, ReikoYoshida, RashidManzoor, KosukeOkuya, HirokoMiyamoto, HeinzFeldmann, AndreaMarzi, MasahiroSakaitani, AsukaNanbo, AyatoTakada (2020)  A biaryl sulfonamide derivative as a novel inhibitor of filovirus infection Antiviral Research. 183 DOI:10.1016/j.antiviral.2020.104932
Hiroshi Manya , Naoyuki Kuwabara , Ryuichi Kato , Tamao Endo (2020)  FAM3B/PANDER-Like Carbohydrate-Binding Domain in a Glycosyltransferase, POMGNT1 Methods in molecular biology. 2132 609-619 DOI:10.1007/978-1-0716-0430-4_52
Hiroki Yamaguchi, Akiko Kamegawa, Kunio Nakata, Tatsuki Kashiwagi, Yoshinori Fujiyoshi, Kazutoshi Tani, Toshimi Mizukoshi (2020)  Leucine Dehydrogenase: Structure and Thermostability Sub-cellular biochemistry. DOI:10.1007/978-3-030-58971-4_10
Rie Koga, Mami Yamamoto, Takahiro Kosugi, Naohiro Kobayashi, Toshihiko Sugiki, Toshimichi Fujiwara, Nobuyasu Koga (2020)  Robust folding of a de novo designed ideal protein even with most of the core mutated to valine Proceedings of the National Academy of Sciences of the United States of America. DOI:10.1073/pnas.2002120117
Koki Makabe, Ruka Hirota, Yoshihito Shiono, Yoshikazu Tanaka, Takuya Koseki (2020)  Biochemical and structural 1 investigation of rutinosidase from Aspergillus oryzae Applied and Environmental Microbiology. DOI:10.1128/AEM.02438-20
Kentaro Ihara, Masakatsu Hato, Takanori Nakane, Keitaro Yamashita, Tomomi Kimura-Someya, Toshiaki Hosaka, Yoshiko Ishizuka-Katsura, Rie Tanaka, Tomoyuki Tanaka, Michihiro Sugahara, Kunio Hirata, Masaki Yamamoto, Osamu Nureki, Kensuke Tono, Eriko Nango, So Iwata, Mikako Shirouzu (2020)  Isoprenoid_chained lipid EROCOC17+ 4: a new matrix for membrane protein crystallization and a crystal delivery medium in serial femtosecond crystallography Scientific Reports. 10 DOI:10.1038/s41598-020-76277-x
Kazuaki Matoba, Tetsuya Kotani, Akihisa Tsutsumi, Takuma Tsuji, Takaharu Mori, Daisuke Noshiro, Yuji Sugita, Norimichi Nomura, So Iwata, Yoshinori Ohsumi, Toyoshi Fujimoto, Hitoshi Nakatogawa, Masahide Kikkawa, Nobuo N Noda (2020)  Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion nature structural & molecular biology. DOI:10.1038/s41594-020-00518-w
Hua Lu, Takayuki Nakamuro, Keitaro Yamashita, Haruaki Yanagisawa, Osamu Nureki, Masahide Kikkawa, Han Gao, Jiangwei Tian, Rui Shang, Eiichi Nakamura (2020)  B/N-Doped p_Arylenevinylene Chromophores: Synthesis, Properties, and Microcrystal Electron Crystallographic Study Jouenal of the American Chemical Society. DOI:10.1021/jacs.0c10337
Toshiyuki Oda, Haruaki Yanagisawa (2020)  Cryo-electron tomography of cardiac myofibrils reveals a 3D lattice spring within the Z-discs Communications biology. 3 DOI:10.1038/s42003-020-01321-5
Shingo Tojo, Zhikuan Zhang, Hiroyuki Matsui, Masahiro Tahara, Mitsunori Ikeguchi, Mami Kochi, Mami Kamada, Hideki Shigematsu, Akihisa Tsutsumi, Naruhiko Adachi, Takuma Shibata, Masaki Yamamoto, Masahide Kikkawa, Toshiya Senda, Yoshiaki Isobe, Umeharu Ohto, Toshiyuki Shimizu (2020)  Structural analysis reveals TLR7 dynamics underlying antagonism 11 DOI:10.1038/s41467-020-19025-z
Kazutoshi Tani, Ryo Kanno, Yuki Makino, Malgorzata Hall, Mizuki Takenouchi, Michie Imanishi, Long-Jiang Yu, J_rg Overmann, Michael T Madigan, Yukihiro Kimura, Akira Mizoguchi, Bruno M Humbel, Zheng-Yu Wang-Otomo (2020)  Cryo-EM structure of a Ca2+-bound photosynthetic LH2-RC complex containing multiple αβ-polypeptides nature communications. :11,  DOI:10.1038/s41467-020-18748-3
Kazutoshi Tani, Ryo Kanno, Yuki Makino, Malgorzata Hall, Mizuki Takenouchi, Michie Imanishi, Long-Jiang Yu, J_rg Overmann, Michael T Madigan, Yukihiro Kimura, Akira Mizoguchi, Bruno M Humbel, Zheng-Yu Wang-Otomo (2020)  Cryo-EM structure of a Ca2+-bound photosynthetic LH1-RC complex containing multiple αβ-polypeptides nature communications. :11,  DOI:10.1038/s41467-020-18748-3
Hanayo Nakanishi, Tomohiro Nishizawa, Katsumori Segawa, Osamu Nureki, Yoshinori Fujiyoshi, Shigekazu Nagata, Kazuhiro Abe (2020)  Transport Cycle of Plasma Membrane Flippase ATP11C by Cryo-EM Cell reports. 32 :13,  DOI:10.1016/j.celrep.2020.108208
Satoshi Fukuhara, Kazuhiro Kobayashi, Tsukasa Kusakizako, Wataru Iida, Kato Masahiko, Wataru Shihoya, Osamu Nureki (2020)  Structure of the human secretin receptor coupled to an engineered heterotrimeric G protein Biochemical and Biophysical Research Communications. DOI:10.1016/j.bbrc.2020.08.042
Satoshi Murakami, Ui Okada, Hendrik W. van Veen (2020)  Tripartite transporters as mechano‐transmitters in periplasmic alternating‐access mechanisms FEBS letters. DOI:10.1002/1873-3468.13929
Tatsuki Tanaka, Manish Singh, Wataru Shihoya, Keitaro Yamashita, Hideki Kandori, Osamu Nureki (2020)  Structural basis for unique color tuning mechanism in heliorhodopsin Biochemical and Biophysical Research Communications. DOI:10.1016/j.bbrc.2020.06.124
Akiyuki Taruno1,2 & Kengo Nomura1 & Tsukasa Kusakizako3 & Zhongming Ma & Osamu Nureki & J. Kevin Foskett (2020)  Taste transduction and channel synapses in taste buds Pfl_gers Archiv - European Journal of Physiology. DOI:10.1007/s00424-020-02464-4
Hirotake Furihata, Satoshi Yamanaka, Toshiaki Honda, Yumiko Miyauchi, Atsuko Asano, Norio Shibata, Masaru Tanokura, Tatsuya Sawasaki, Takuya Miyakawa (2020)  Structural bases of IMiD selectivity that emerges by 6-hydroxythalidomide nature communications. DOI:10.1038/s41467-020-18488-4
Tomoya Kujirai, Christian Zierhut, Yoshimasa Takizawa, Ryan Kim, Lumi Negishi, Nobuki Uruma, Seiya Hirai, Hironori Funabiki, Hitoshi Kurumizaka (2020)  Structural basis for the inhibition of cGAS by nucleosomes Science . DOI:10.1126/science.abd0237
Norimasa Iwanami, Divine-Fondzenyuy Lawir, Katarzyna Sikora, Connor O Meara, Kohei Takeshita, Michael Schorpp, Thomas Boehm (2020)  Transgenerational inheritance of impaired larval Tcell development in zebrafish nature communications. 11 DOI:10.1038/s41467-020-18289-9
Masatoshi Maeki, Sho Ito, Reo Takeda, Go Ueno, Akihiko Ishida, Hirofumi Tani, Masaki Yamamoto and Manabu Tokeshi (2020)  Room-temperature crystallography using a microfluidic protein crystal array device and its application to protein_ligand complex structure analysis Chemical Science. DOI:10.1039/D0SC02117b
Hiroki Tanaka, Yoshimasa Takizawa , Motoki Takaku , Daiki Kato , Yusuke Kumagawa , Sara A Grimm, Paul A Wade, Hitoshi Kurumizaka (2020)  Interaction of the pioneer transcription factor GATA3 with nucleosomes nature communications. 11 DOI:10.1038/s41467-020-17959-y
Jun-Ichi Kishikawa, Atsuko Nakanishi, Aya Furuta, Takayuki Kato, Keiichi Namba, Masatada Tamakoshi, Kaoru Mitsuoka, Ken Yokoyama (2020)  Mechanical inhibition of isolated Vo from V/A-ATPase for proton conductance eLife. 9 e56862- DOI:10.7554/eLife.56862
Riki Imaizumi,_ Ryo Mameda,_ Kohei Takeshita,_ Hiroki Kubo,_ Naoki Sakai,_ Shun Nakata,_ Seiji Takahashi,_ Kunishige Kataoka_ Masaki Yamamoto,_ Toru Nakayama,_ Satoshi Yamashita,_ Toshiyuki Waki (2020)  Crystal structure of chalcone synthase, a key enzyme for isoflavonoid biosynthesis in soybean proteins. DOI:10.1002/prot.25988
Honjie Li, Yoshiki Nakajima, Takashi Nomura,Michihiro Sugahara, Shinichiro Yonekura, Siu Kit Chan, Takanori Nakane, Takahiro Yamane, Yasufumi Umena, Mamoru Suzuki, Tetsuya Masuda, Taiki Motomura, Hisashi Naitow, Yoshinori Matsuura, Tetsunari Kimura, Kensuke Tono, Shigeki Owada, Yasumasa Joti, Rie Tanaka, Eriko Nango, Fusamichi Akita, Minoru Kubo, So Iwata, Jian-Ren Shen, Michihiro Suga (2020)  Capturing structural changes of photosystem II using time-resolved serial femtosecond crystallography with proper flash excitations _Nature Research journal. DOI:10.21203/rs.3.rs-41101/v1
Kenta Echigoya, Masako Koyama, Lumi Negishi, Yoshimasa Takizawa, Yuka Mizukami, Hideki Shimabayashi, Akari Kuroda, Hitoshi Kurumizaka (2020)  Nucleosome binding by the pioneer transcription factor OCT5 Scientific Reports. 10 DOI:10.1038/s41598-020-68850-1
Kenta Echigoya, Masako Koyama, Lumi Negishi, Yoshimasa Takizawa, Yuka Mizukami, Hideki Shimabayashi, Akari Kuroda, Hitoshi Kurumizaka (2020)  Nucleosome binding by the pioneer transcription factor OCT5 Scientific Reports. 10 DOI:10.1038/s41598-020-68850-1
Takaaki Hikima (2020)  BL45XU(RIKEN Structural Biology I) RIKEN Beamlines.
Hiroto Shimada, Tsukasa Kusakizako, T. H. Dung Nguyen, Tomohiro Nishizawa, Tomoya Hino, Makoto Tominaga & Osamu Nureki_ (2020)  The structure of lipid nanodisc-reconstituted TRPV3 reveals the gating mechanism nature structural & molecular biology. DOI:10.1038/s41594-020-0439-z
Simon Miller, Yoshiki Aikawa, Akiko Sugiyama, Yoshiko Nagai, Aya Hara, Tsuyoshi Oshima, Kazuma Amaike, Steve A Kay, Kenichiro Itami, Tsuyoshi Hirota (2020)  An Isoform-Selective Modulator of Cryptochrome 2 Regulates Circadian Rhythms in Mammals cell chemical biology. DOI:10.1016/j.chembiol.2020.05.008
Rina C Sakata, Soh Ishiguro, Hideto Mori, Mamoru Tanaka, Kenji Tatsuno, Hiroki Ueda, Shogo Yamamoto, Motoaki Seki, Nanami Masuyama, Keiji Nishida, Hiroshi Nishimasu, Kazuharu Arakawa, Akihiko Kondo, Osamu Nureki_, Masaru Tomita, Hiroyuki Aburatani , Nozomu Yachie  (2020)  Base Editors for Simultaneous Introduction of C-to-T and A-to-G Mutations Nature Biotechnology. DOI:10.1038/s41587-020-0509-0
Ryo Nagao, Koji Kato, Kentaro Ifuku, Takehiro Suzuki, Minoru Kumazawa, Ikuo Uchiyama, Yasuhiro Kashino, Naoshi Dohmae, Seiji Akimoto, Jian-Ren Shen, Naoyuki Miyazaki, Fusamichi Akita (2020)  Structural Basis for Assembly and Function of a Diatom Photosystem I-light-harvesting Supercomplex Nature Communications. 11 2481- DOI:10.1038/s41467-020-16324-3
Kenta Okamoto , Ricardo J Ferreira , Daniel S D Larsson , Filipe R N C Maia , Haruhiko Isawa, Kyoko Sawabe , Kazuyoshi Murata , Janos Hajdu, Kenji Iwasaki_ , Peter M Kasson , Naoyuki Miyazaki_ (2020)  Acquired Functional Capsid Structures in Metazoan Totivirus-like dsRNA Virus Structure. DOI:10.1016/j.str.2020.04.016
Fusamichi Akita, Ryo Nagao, Koji Kato, Yoshiki Nakajima, Makio Yokono, Yoshifumi Ueno, Takehiro Suzuki, Naoshi Dohmae. Jian-Ren Shen, Seiji Akimoto, Naoyuki Miyazaki_ (2020)  Structure of a Cyanobacterial Photosystem I Surrounded by Octadecameric IsiA Antenna Proteins Communications Biology. 3 :1,  - DOI:10.1038/s42003-020-0949-6
Taro Masuda , Seiki Baba , Koichi Matsuo , Shinji Ito , Bunzo Mikami_  (2020)  The High-Resolution Crystal Structure of Lobster Hemocyanin Shows Its Enzymatic Capability as a Phenoloxidase Archives of Biochemistry and Biophysics . 688 108370- DOI:10.1016/j.abb.2020.108370.
Hiroshi Iijima, Katsuki Takebe, Mamoru Suzuki, Hiroko Kobayashi, TomokoTakamiya, Hiroaki Saito, Norio Niwa, and Takao Kuwada-Kusunose (2020)  Crystal Structure of Catechol O-Methyltransferase Complexed with Nitecapone Chemical and Pharmaceutical Bulletin. 68 :5,  447-451 DOI:10.1248/cpb.c20-00011
Tsuneyuki Kobayashi, Takamitsu Hosoya, and Suguru Yoshida (2020)  Aryne Reaction and Cross-Coupling Approach for the Synthesis of Diverse N-Arylphenylalanine Derivatives Chemistry Letters. DOI:10.1246/cl.200276
Chenjiang Liu, Yoshihiro Kobashigawa, Soichiro Yamauchi, Natsuki Fukuda, Takashi Sato, Takeshi Masuda, Sumio Ohtsuki , Hiroshi Morioka_ (2020)  Convenient Method of Producing Cyclic Single-Chain Fv Antibodies by Split-Intein-Mediated Protein Ligation and Chaperone Co-Expression The Journal of Biochemistry. DOI:10.1093/jb/mvaa042
Hiroyoshi Hamada ,Takayuki Nakamuro ,Keitaro Yamashita ,Haruaki Yanagisawa ,Osamu Nureki , Masahide Kikkawa ,Koji Harano ,Rui Shang , and Eiichi Nakamura  (2020)  Spiro-conjugated Carbon/Heteroatom-bridged p-Phenylenevinylenes: Synthesis, Properties, and Microcrystal Electron Crystallographic Analysis of Racemic Solid Solutions Bulletin of the Chemical Society of Japan. DOI:10.1246/bcsj.20200065
Minghao Chen, Masato Ishizaka, Shun Narai, Masaki Horitani, Naoki Shigi, Min Yao & Yoshikazu Tanaka (2020)  The [4Fe-4S] cluster of sulfurtransferase TtuA desulfurizes TtuB during tRNA modification in Thermus thermophilus Communications Biology. 3 :1,  DOI:10.1038/s42003-020-0895-3
Rafaella Stepanova, Hayato Inagi, Kei Sugawara, Kazuya Asada, Tomoyuki Nishi,DaijiroUeda, Yoko Yasuno, Tetsuro Shinada, Kunio Miki, Masahiro Fujihashi, and Tsutomu Sato (2020)  Characterization of Class IB terpene synthase: thefirst crystalstructurebound with substrate surrogate ACS Chemical Biology. DOI:10.1021/acschembio.0c00145
KengoKitadokoro, MutsumiTanaka, takaakiHikima, YukikoOkuno, MasakiYamamoto & ShigekiKamitani (2020)  Crystal structure of pathogenic Staphylococcus aureuslipase complex with theanti-obesity drug orlistat Scientific Reports. 10 :1,  DOI:10.1038/s41598-020-62427-8
Mao Oide, Takayuki Kato, Tomotaka Oroguchi & Masayoshi Nakasako (2020)  Energy landscape of domain motion in glutamate dehydrogenase deduced from cryo-electron microscopy. The FEBS Journal. DOI:10.1111/febs.15224
Tomoko Yamaguchi, Shoko Toma, Naoya Terahara, Tomoko Miyata, Masamichi Ashihara, Tohru Minamino, Keiichi Namba, Takayuki Kato (2020)  Structural and Functional Comparison of Salmonella Flagellar Filaments Composed of FljB and FliC Bimolecules. 10 :2,  246- DOI:10.3390/biom10020246
Yurika Yamada, Keiichi Namba & Takashi Fujii  (2020)  Cardiac muscle thin filament structures reveal calcium regulatory mechanism Nature Communications. 11 153- DOI:10.1038/s41467-019-14008-1
Hiroyuki Terashima, Chinatsu Tatsumi, Akihiro Kawamoto, Keiichi Namba, Tohru Minamino, and Katsumi Imada (2020)  In Vitro Autonomous Construction of the Flagellar Axial Structure in Inverted Membrane Vesicles Biomolecules. 10 :1,  126- DOI:10.3390/biom10010126
Batuujin Burendei, Ruriko Shinozaki, Masakatsu Watanabe, Tohru Terada, Kazutoshi Tani, Yoshinori Fujiyoshi, and Atsunori Oshima  (2020)  Cryo-EM structures of undocked innexin-6 hemichannels in phospholipids Science Advances. 6 eaax3157- DOI:10.1126/sciadv.aax3157
Yuichi Yokoyama, Tohru Terada, Kentaro Shimizu, Kouki Nishikawa, Daisuke Kozai, Atsuhiro Shimada, Akira Mizoguchi, Yoshinori Fujiyoshi, Kazutoshi Tani  (2020)  Development of a deep learning-based method to identify “good” regions of a cryo-electron microscopy grid Biophysical Reviews. DOI:10.1007/s12551-020-00669-6
Masahiko Okuda and Yoshifumi Nishimura  (2020)  The Eaf3 chromodomain acts as a pH sensor for gene expression by altering its binding affinity for histone methylated-lysine residues. Bioscience Reports . 40 :2,  DOI:10.1042/BSR20191958.
Hidetsugu Asada, Asuka Inoue, Francois Marie Ngako Kadji, Kunio Hirata, Yuki Shiimura, Dohyun Im, Tatsuro Shimamura, Norimichi Nomura, Hiroko Iwanari, Takao Hamakubo, Osamu Kusano-Arai, Hiromi Hisano, Tomoko Uemura, Chiyo Suno, Junken Aoki, So Iwata, (2020)  The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone Structure. 28 :4,  418-425 DOI:10.1016/j.str.2019.12.003
Rie Umeda, Yuhkoh Satouh, Mizuki Takemoto, Yoshiko Nakada-Nakura, Kehong Liu, Takeshi Yokoyama, Mikako Shirouzu, So Iwata, Norimichi Nomura, Ken Sato, Masahito Ikawa, Tomohiro Nishizawa& Osamu Nureki_  (2020)  Structural insights into tetraspanin CD9 function Nature Communications. 11 :1,  1606- DOI:10.1038/s41467-020-15459-7
Yasunori Watanabe, Yasushi Tamura, Chika Kakuta, Seiya Watanabe and Toshiya Endo  (2020)  Structural basis for interorganelle phospholipid transport mediated by VAT-1 Journal of Biological Chemistry. 295 :10,  3257-3268 DOI:10.1074/jbc.RA119.011019
Yoshizawa, Takuya; Fujita, Junso; Terakado, Haruna; Ozawa, Mayuki; Kuroda, Natsuko; Tanaka, Shun-ichi; Uehara, Ryo; Matsumura, Hiroyoshi;  (2020)  Crystal structures of the cell-division protein FtsZ from Klebsiella pneumoniae and Escherichia coli Acta Crystallographica Section F: Structural Biology Communications. 76 :2,  86-93 DOI:10.1107/S2053230X2000076X
Masakazu Sugishima, Kei Wada, Keiichi Fukuyama and Ken Yamamoto  (2020)  Crystal structure of phytochromobilin synthase in complex with biliverdin IXα, a key enzyme in the biosynthesis of phytochrome Journal of Biological Chemistry. 295 :3,  771-782 DOI:10.1074/jbc.RA119.011431
TamakiIzume, HirotakeMiyauch, iWataruShihoya, OsamuNureki  (2020)  Crystal structure of human endothelin ETB receptor in complex with sarafotoxin S6b Biochemical and Biophysical Research Communications. DOI:10.1016/j.bbrc.2019.12.091
Elin Claesson, Weixiao Yuan Wahlgren, Heikki Takala, Suraj Pandey, Leticia Castillon, Valentyna Kuznetsova, L_ocadie Henry, Matthijs Panman, Melissa Carrillo, Joachim K_bel, Rahul Nanekar, Linn_a Isaksson, Amke Nimmrich, Andrea Cellini, Dmitry Morozov, Micha_ Maj, Moona Kurttila, Robert Bosman, Eriko Nango, Rie Tanaka, Tomoyuki Tanaka, Luo Fangjia, So Iwata, Shigeki Owada, Keith Moffat, Gerrit Groenhof, Emina A. Stojkovi_, Janne A. Ihalainen, Marius Schmidt, Sebastian Westenhoff__  (2020)  The primary structural photoresponse of phytochrome proteins captured by a femtosecond X-ray laser eLife. 9 e53514- DOI:10.7554/eLife.53514
Yuichi Mishima_ Laura Brueckner_ Saori Takahashi_ Toru Kawakami_ Junji Otani_ Akira Shinohara_ Kohei Takeshita_ Ronald Garingalao Garvilles_ Mikio Watanabe_ Norio Sakai_ Hideyuki Takeshima_ Charlotte Nachtegael_ Atsuya Nishiyama_ Makoto Nakanishi_ Kyohei Arita_ Kinichi Nakashima_ Hironobu Hojo_ Isao Suetake (2020)  Enhanced processivity of Dnmt1 by monoubiquitinated histone H3. Gene to Cells. 25 :1,  22-32 DOI:10.1111/gtc.12732
Kengo Kitadokoro, Mutsumi Tanaka, Takaaki Hikima, Yukiko Okuno, Masaki Yamamoto, Shigeki Kamitani  (2020)  Crystal structure of pathogenic Staphylococcus aureus lipase complex with the anti-obesity drug orlistat Scientific Reports. 10 5469- DOI:10.1038/s41598-020-62427-8
Hironori Murakami, Kazuya Hasegawa, Go Ueno, Naoto Yagi, Masaki Yamamoto, and Takashi Kumasaka,  (2020)  Development of SPACE-II for rapid sample exchange at SPring-8 macromolecular crystallography beamlines Acta Crystallographica Section D. D76 155-165 DOI:10.1107/S2059798320000030
Ryosuke Nakamura_ Masahide Hikita_ Shoko Ogawa_ Yasuhiro Takahashi_ Takashi Fujishiro (2020)  Snapshots of PLP-substrate and PLP-product external aldimines as intermediates in two types of cysteine desulfurase enzymes. FEBS Journal. 287 :6,  1138-1154 DOI:10.1111/febs.15081
Tomohiko Hayashi, Satoshi Yasuda, Kano Suzuki, Tomoki Akiyama, Kanae Kanehara, Keiichi Kojima, Mikio Tanabe, Ryuichi Kato, Toshiya Senda, Yuki Sudo, Takeshi Murata, Masahiro Kinoshita (2020)  How Does a Microbial Rhodopsin RxR Realize Its Exceptionally High Thermostability with the Proton-Pumping Function Being Retained? The Journal of Physical Chemistry B. 124 :6,  990-1000 DOI:10.1021/acs.jpcb.9b10700
Kenji Ite, Kento Yonezawa, Kenichi Kitanishi, Nobutaka Shimizu, Masaki Unno (2020)  Optimal Mutant Model of Human S100A3 Protein Citrullinated at Arg51 by Peptidylarginine Deiminase Type III and Its Solution Structural Properties ACS Omega. 5 :8,  4032-4042 DOI:10.1021/acsomega.9b03618
Afifa Ayu Koesoema, Daron M. Standley, Toshiya Senda, Tomoko Matsuda  (2020)  Impact and relevance of alcohol dehydrogenase enantioselectivities on biotechnological applications Applied Micribiology and Biotechnology. 104 2897-2909 DOI:10.1007/s00253-020-10440-2
Naoyuki Kuwabara, Rieko Imae, Hiroshi Manya, Tomohiro Tanaka, Mamoru Mizuno, Hiroki Tsumoto, Motoi Kanagawa, Kazuhiro Kobayashi, Tatsushi Toda, Toshiya Senda, Tamao Endo, Ryuichi Kato  (2020)  Crystal structures of fukutin-related protein (FKRP), a ribitol-phosphate transferase related to muscular dystrophy Nature Communications. 11 303- DOI:10.1038/s41467-019-14220-z
N_ra Taricska, D_niel Horv_th, D_ra K. Menyh_rd, Hanna _kontz-Kiss, Masahiro Noji, Masatomo So, Yuji Goto, Toshimichi Fujiwara and Andr_s Perczel (2020)  The route from the folded to the amyloid state: exploring the potential energy surface of a drug-like miniprotein Chemistry a European Journal. 26 1968-1978 DOI:10.1002/chem.201905180
YoheiMiyanoiri, MitsuhiroTakeda, TsutomuTerauchi, MasatsuneKainoshobe (2020)  Recent developments in isotope-aided NMR methods for supramolecular protein complexes _SAIL aromatic TROSY Biochimica et Biophysica Acta (General Subjects),. 1864 :2,  DOI:10.1016/j.bbagen.2019.129439
Toshihiko Sugiki, Yoshihiro Yamaguchi, Toshimichi Fujiwara, Masayori Inouye, Yutaka Ito, Chojiro Kojima (2020)  In-cell NMR as a Sensitive Tool to Monitor Physiological Condition of Escherichia Coli Scientific Reports. 10 2466- DOI:10.1038/s41598-020-59076-2
Koji Kato, Toshiyuki Shinoda, Ryo Nagao, Seiji Akimoto, Takehiro Suzuki, Naoshi Dohmae, Min Chen, Suleyman I. Allakhverdiev, Jian-Ren Shen, Fusamichi Akita, Naoyuki Miyazaki, Tatsuya Tomo (2020)  Structural basis for the adaptation and function of chlorophyll f in photosystem I Nature Communications. 1 238- DOI:10.1038/s41467-019-13898-5
Masafumi Tanaka, Hisayasu Miyake, Satoko Oka, Shintaro Maeda. Kenji Iwasaki. Takahiro Mukai (2020)  Effects of charged lipids on the physicochemical and biological properties of lipid_styrene maleic acid copolymer discoidal particles Biochimica et Biophysica Acta Biomembranes. 1862 :5,  183209- DOI:10.1016/j.bbamem.2020.183209
Tomohito Yamada, Toru Yoshida, Akihiro Kawamoto, Kaoru Mitsuoka, Kenji Iwasaki, Hideaki Tsuge (2020)  Cryo-EM structures reveal translocational unfolding in the clostridial binary iota toxin complex Nature Structural Molecular Biology. 27 288-296 DOI:10.1038/s41594-020-0388-6
Sandra Huber, Anina B_r, Selina Epp, Jacqueline Schmuckli-Maurer, Naja Eberhard, Bruno M. Humbel, Andrew Hemphill, Kerry Woods  (2020)  Recruitment of Host Nuclear Pore Components to the Vicinity of Theileria Schizonts mSphere. 5 e00709-719 DOI:10.1128/mSphere.00709-19.
Hamazaki N, Kyogoku H, Araki H, Miura F, Horikawa C, Hamada N, Shimamoto S, Hikabe O, Nakashima K, Kitajima TS, Ito T, Leitch HG, Hayashi K. (2020)  Reconstitution of the oocyte transcriptional network with transcription factors. Nature. :online ahead of print.,  DOI:10.1038/s41586-020-3027-9 PMID:33328630 
YUSUKE SAYAMA, MIKA K. KANEKO and YUKINARI KATO (2020)  Development and characterization of TrMab_6, a novel anti_TROP2 monoclonal antibody for antigen detection in breast cancer Molecular medicine reports. 23 :2,  DOI:10.3892/mmr.2020.11731
Satoshi Kamoto, Masahiro Shinada, Daiki Kato, Sho Yoshimoto, Namiko Ikeda, Masaya Tsuboi, Ryohei Yoshitake, Shotaro Eto, Yuko Hashimoto, Yosuke Takahashi, James Chambers, Kazuyuki Uchida, Mika K Kaneko, Naoki Fujita, Ryohei Nishimura, Yukinari Kato, Takayuki Nakagawa (2020)  Phase I/II Clinical Trial of the Anti-Podoplanin Monoclonal Antibody Therapy in Dogs with Malignant Melanoma Cells. 11 E2529- DOI:10.3390/cells9112529
Nasir K Bashiruddin, Mikihito Hayashi, Masanobu Nagano, Yan Wu, Yukiko Matsunaga, Junichi Takagi, Tomoki Nakashima, Hiroaki Suga (2020)  Development of cyclic peptides with potent in vivo osteogenic activity through RaPID-based affinity maturation Proceedings of the National Academy of Sciences of the United States of America. DOI:10.1073/pnas.2012266117
Kentaro Ihara, Masakatsu Hato, Takanori Nakane, Keitaro Yamashita, Tomomi Kimura-Someya, Toshiaki Hosaka, Yoshiko Ishizuka-Katsura, Rie Tanaka, Tomoyuki Tanaka, Michihiro Sugahara, Kunio Hirata, Masaki Yamamoto, Osamu Nureki, Kensuke Tono, Eriko Nango, So Iwata, Mikako Shirouzu (2020)  Isoprenoid_chained lipid EROCOC17+ 5: a new matrix for membrane protein crystallization and a crystal delivery medium in serial femtosecond crystallography Scientific Reports. 10 DOI:10.1038/s41598-020-76277-x
Yoshimi Shimizu, Takehiro Shinoda, Yoshitaka Shirasago, Masuo Kondoh, Naoko Shinya, Kentaro Hanada, Kiyohito Yagi, Tetsuro Suzuki, Takaji Wakita, Tomomi Kimura-Someya, Mikako Shirouzu, Masayoshi Fukasawa (2020)  Occludin-binding single-chain variable fragment and antigen-binding fragment antibodies prevent hepatitis C virus infection FEBS letters. DOI:10.1002/1873-3468.13975
Kazutaka Murayama, Miyuki Kato-Murayama, Yuka Itoh, Kohei Miyazono, Keiji Miyazawa, Mikako Shirouzu (2020)  Structural basis for inhibitory effects of Smad7 on TGF-β family signaling Journal of Structural Biology. DOI:10.1016/j.jsb.2020.107661
Yoshimi Shimizu, Takehiro Shinoda, Yoshitaka Shirasago, Masuo Kondoh, Naoko Shinya, Kentaro Hanada, Kiyohito Yagi, Tetsuro Suzuki, Takaji Wakita, Tomomi Kimura-Someya, Mikako Shirouzu, Masayoshi Fukasawa (2020)  Occludin-binding single-chain variable fragment and antigen-binding fragment antibodies prevent hepatitis C virus infection FEBS Lertters. DOI:10.1002/1873-3468.13975
Kazuaki Matoba, Tetsuya Kotani, Akihisa Tsutsumi, Takuma Tsuji, Takaharu Mori, Daisuke Noshiro, Yuji Sugita, Norimichi Nomura, So Iwata, Yoshinori Ohsumi, Toyoshi Fujimoto, Hitoshi Nakatogawa, Masahide Kikkawa, Nobuo N Noda (2020)  Atg10 is a lipid scramblase that mediates autophagosomal membrane expansion nature structural & molecular biology. DOI:10.1038/s41594-020-00518-w
Hideki Hosono Tomokazu Ohishi Junko Takei Teizo Asano Yusuke Sayama Manabu Kawada Mika K. Kaneko Yukinari Kato (2020)  The anti_epithelial cell adhesion molecule (EpCAM) monoclonal antibody EpMab_16 exerts antitumor activity in a mouse model of colorectal adenocarcinoma Oncology Letters. DOI:10.3892/ol.2020.12246
Mika K Kaneko, Tomokazu Ohishi, Takuro Nakamura, Hiroyuki Inoue, Junko Takei, Masato Sano, Teizo Asano, Yusuke Sayama, Hideki Hosono, Hiroyoshi Suzuki, Manabu Kawada, Yukinari Kato (2020)  Development of Core-Fucose-Deficient Humanized and Chimeric Anti-Human Podoplanin Antibodies Monoclonal Antibodies in Immunodiagnosis and Immunotherapy . 39 :5,  DOI:10.1089/mab.2020.0019
Chan-I Chung, Yuko Sato, Yuki Ohmuro-Matsuyama, Shinichi Machida, Hitoshi Kurumizaka, Hiroshi Kimura, Hiroshi Ueda (2020)  Intrabody-based FRET probe to visualize endogenous histone acetylation Scientific Reports. 9 DOI:10.1038/s41598-019-46573-2
Satoshi Arai, Shintaro Maruyama, Mitsunori Shiroishi, Ichiro Yamato, Takeshi Murata (2020)  An affinity change model to elucidate the rotation mechanism of V1- ATPase Biochemical and Biophysical Research Communications. DOI:10.1016/j.bbrc.2020.10.033
MIKA K. KANEKO, TOMOKAZU OHISHI, JUNKO TAKEI, MASATO SANO,TAKURO NAKAMURA, HIDEKI HOSONO, MIYUKI YANAKA, TEIZO ASANO, YUSUKE SAYAMA, HIROYUKI HARADA, MANABU KAWADA andYUKINARI KATO (2020)  Anti_EpCAM monoclonal antibody exerts antitumor activity against oral squamous cell carcinomas ONCOLOGY REPORTS. DOI:10.3892/or.2020.7808
Mika K. Kaneko, Tomokazu Ohishi, Manabu Kawada, Yukinari Kato (2020)  A cancer-specific anti-podocalyxin monoclonal antibody (60-mG2a-f) exerts antitumor effects in mouse xenograft models of pancreatic carcinoma Biochemistry and Biophysics Reports. 24 DOI:10.1016/j.bbrep.2020.100826
Emiko Mihara, Satoshi Watanabe, Nasir Bashiruddin, Nozomi Nakamura, Kyoko Matoba, Rumit Maini, Yizhen Yin, Katsuya Sakai, Takao Arimori, Kunio Matsumoto, Hiroaki Suga, Junichi Takagi (2020)  Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins chemical Biology. DOI:10.21203/rs.3.rs-85705/v1
Hisashi Yoshida, Sam-Yong Park, Gyosuke Sakashita, Yuko Nariai, Kanako Kuwasako, Yutaka Muto, Takeshi Urano, Eiji Obayashi (2020)  Elucidation of the aberrant 3′ splice site selection by cancer-associated mutations on the U2AF2 nature communications. 11 DOI:10.1038/s41467-020-18559-6
Satoshi Yamanaka, Yuki Shoya, Saya Matsuoka, Hisayo Nishida-Fukuda, Norio Shibata, Tatsuya Sawasaki (2020)  An IMiD-induced SALL4 degron system for selective degradation of target proteins comunications biology. 3 DOI:10.1038/s42003-020-01240-5
Kazumi Saikusa, Haruna Hidaka, Shunsuke Izumi, Satoko Akashi (2020)  Mass spectrometric characterization of histone H3 isolated from in-vitro reconstituted and acetylated nucleosome core particle massspectrometry advace publication. DOI:10.5702/massspectrometry.A0090
Hirotake Furihata, Satoshi Yamanaka, Toshiaki Honda, Yumiko Miyauchi, Atsuko Asano, Norio Shibata, Masaru Tanokura, Tatsuya Sawasaki, Takuya Miyakawa (2020)  Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide nature communications. DOI:10.1038/s41467-020-18488-4
Tomoya Kujirai, Christian Zierhut, Yoshimasa Takizawa, Ryan Kim, Lumi Negishi, Nobuki Uruma, Seiya Hirai, Hironori Funabiki, Hitoshi Kurumizaka (2020)  Structural basis for the inhibition of cGAS by nucleosomes Science . DOI:10.1126/science.abd0237
Satoshi Ogasawara, Kano Suzuki, Kentaro Naruchi, Seiwa Nakamura, Junpei Shimabukuro, Nanase Tsukahara, Mika K. Kaneko, Yukinari Kato, Takeshi Murata (2020)  Crystal structure of an anti-podoplanin antibody bound to a disialylated O-linked glycopeptide Biochemical and Biophysical Research Communications. DOI:10.1016/j.bbrc.2020.08.103
Satoshi Ogasawara, Kano Suzuki, Kentaro Naruchi, Seiwa Nakamura, Junpei Shimabukuro, Nanase Tsukahara, Mika K. Kaneko, Yukinari Kato, Takeshi Murata (2020)  Crystal structure of an anti-podoplanin antibody bound to a disialylated O-linked glycopeptide Biochemical and Biophysical Research Communications. DOI:10.1016/j.bbrc.2020.08.103
MasatoSano, TeizoAsano, Mika K.Kaneko, YukinariKato (2020)  Epitope mapping of an anti-diacylglycerol kinase delta monoclonal antibody DdMab-1 Biochemistry and Biophysics Reports. 24 DOI:10.1016/j.bbrep.2020.100808
Tetsuya Handa, Akihito Harada, Kazumitsu Maehara, Shoko Sato, Masaru Nakao, Naoki Goto, Hitoshi Kurumizaka, Yasuyuki Ohkawa, Hiroshi Kimura (2020)  Chromatin integration labeling for mapping DNA-binding proteins and modifications with low input Nature protocols. DOI:10.1038/s41596-020-0375-8
Yuki Shiimura , Shoichiro Horita , Akie Hamamoto , Hidetsugu Asada , Kunio Hirata , Misuzu Tanaka , Kenji Mori , Tomoko Uemura , Takuya Kobayashi , So Iwata , Masayasu Kojima (2020)  Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode nature communications. 11 DOI:10.1038/s41467-020-17554-1
Hiroaki Tanabe, Yoshifumi Fujii, Miki Okada-Iwabu, Masato Iwabu, Kuniyuki Kano, Hiroki Kawana, Masakatsu Hato, Yoshihiro Nakamura, Takaho Terada, Tomomi Kimura-Someya, Mikako Shirouzu, Yoshiaki Kawano, Masaki Yamamoto, Junken Aoki, Toshimasa Yamauchi, Takashi Kadowaki, Shigeyuki Yokoyama  (2020)  Human adiponectin receptor AdipoR1 assumes closed and open structures Communications biology. 3 :1,  DOI:10.1038/s42003-020-01160-4
_Junko Takei, Mika K. Kaneko, Tomokazu Ohishi, Hideki Hosono, Takuro Nakamura, Miyuki Yanaka, Masato Sano, Teizo Asano, Yusuke Sayama, Manabu Kawada, Hiroyuki Harada, Yukinari Kato (2020)  A defucosylated anti_CD44 monoclonal antibody 5_mG2a_f exerts antitumor effects in mouse xenograft models of oral squamous cell carcinoma OncologyReports. DOI:10.3892/or.2020.7735
Naoe Kaneko, Mie Kurata, Toshihiro Yamamoto, Tomonari Shigemura, Kazunaga Agematsu, Takashi Yamazaki, Hiroyuki Takeda, Tatsuya Sawasaki, Tomohiro Koga, Atsushi Kawakami, Akihiro Yachie, Kiyoshi Migita, Koh-Ichiro Yoshiura, Takeshi Urano, Junya Masumoto  (2020)  KN3014, a piperidine_containing small compound, inhibits auto_secretion of IL_1β from PBMCs in a patient with Muckle_Wells syndrome Scientific Reports. 10 DOI:10.1038/s41598-020-70513-0
Hideki Hosono, Junko Takei, Tomokazu Ohishi, Masato Sano, Teizo Asano, Yusuke Sayama, Takuro Nakamura, Miyuki Yanaka, Manabu Kawada, Hiroyuki Harada, Mika Kato Kaneko, Yukinari Kato (2020)  Anti_EGFR monoclonal antibody 134_mG2a exerts antitumor effects in mouse xenograft models of oral squamous cell carcinoma International Journal of Molecular Medicine . 46 :4,  DOI:10.3892/ijmm.2020.4700
Tomoya Fujita, Takeshi Yokoyama, Mikako Shirouzu, Hideki Taguchi, Takuhiro Ito, and Shintaro Iwasaki (2020)  Anatomy of footprint extension in ribosome profiling reveals translational landscape mediated by S1 protein in bacteria Biological science /Biochemistry. DOI:10.21203/rs.3.rs-41219/v1
Koki Ikeda, Shota Suzuki, Yoshiki Shigemitsu, Takeshi Tenno, Natsuko Goda, Atsunori Oshima, Hidekazu Hiroaki (2020)  Presence of intrinsically disordered proteins can inhibit the nucleation phase of amyloid fibril formation of Aβ(1_42) in amino acid sequence independent manner Scientific Reports. 10 DOI:10.1038/s41598-020-69129-1
Kenta Echigoya, Masako Koyama, Lumi Negishi, Yoshimasa Takizawa, Yuka Mizukami, Hideki Shimabayashi, Akari Kuroda, Hitoshi Kurumizaka (2020)  Nucleosome binding by the pioneer transcription factor OCT4 Scientific Reports. 10 DOI:10.1038/s41598-020-68850-1
Masahiro Nishimura, Yasuhiro Arimura, Kayo Nozawa, Hitoshi Kurumizaka (2020)  Linker DNA and histone contributions in nucleosome binding by p53 The Journal of Biochemistry. DOI:10.1093/jb/mvaa081
Christoph Gerle (2020)  Mitochondrial F-ATP synthase as the permeability transition pore Pharmacological Research. 160 DOI:10.1016/j.phrs.2020.105081
Mika K Kaneko, Masato Sano, Junko Takei, Teizo Asano, Yusuke Sayama, Hideki Hosono, Atsushi Kobayashi, Satoru Konnai, Yukinari Kato (2020)  Development and Characterization of Anti-Sheep Podoplanin Monoclonal Antibodies PMab-253 and PMab-260 Monoclonal Antibodies in Immunodiagnosis and Immunotherapy . DOI:10.1089/mab.2020.0018
Yoshikazu Furusawa, Mika K Kaneko, Yukinari Kato (2020)  Establishment of an Anti-CD20 Monoclonal Antibody(C20Mab-60) for Immunohistochemical Analyses Monoclonal Antibodies in Immunodiagnosis and Immunotherapy . DOI:10.1089/mab.2020.0015
Kenta Echigoya, Masako Koyama, Lumi Negishi, Yoshimasa Takizawa, Yuka Mizukami, Hideki Shimabayashi, Akari Kuroda, Hitoshi Kurumizaka (2020)  Nucleosome binding by the pioneer transcription factor OCT4 Scientific Reports. 10 DOI:10.1038/s41598-020-68850-1
Masato Sano, Mika K. Kaneko, and Yukinari Kato (2020)  Epitope Mapping of DhMab-1:An Antidiacylglycerol Kinase Monoclonal Antibody Monoclonal Antibodies in Immunodiagnosis and Immunotherapy . 39 DOI:10.1089/mab.2020.0014
Yoshikazu Furusawa, Mika Kato Kaneko, Yukinari Kato (2020)  Establishment of C20Mab_11, a novel anti_CD20 monoclonal antibody, for the detection of B cells Oncology Letters. 20 1961-1967 DOI:10.3892/ol.2020.11753
Shinya, Goto; Satoru, Konnai; Yuki, Hirano; Junko, Kohara; Tomohiro, Okagawa; Naoya, Maekawa; Yamato, Sajiki; Kei, Watari; Erina, Minato; Atsuhi, Kobayashi; Satoshi, Gondaira; Hidetoshi, Higuchi; Masateru, Koiwa; Motoshi, Tajima; Eiji, Taguchi; Masaru, Ishida; Ryoko, Uemura; Shinji, Yamada; Mika, K. Kaneko; Yukinari, Kato; Keiichi, Yamamoto; Mikihiro, Toda; Yasuhiko, Suzuki; Shiro, Murata; Kazuhiko, Ohashi (2020)  Clinical efficacy of the combined treatment of anti-PD-L1 rat-bovine chimeric antibody with a COX-2 inhibitor in calves infected with Mycoplasma bovis Japanese Journal of Veterinary Research. 68 :2,  77-90 DOI:10.14943/jjvr.68.2.77
Ken Morishima, Aya Okuda, Rintaro Inoue, Nobuhiro Sato, Yosuke Miyamoto, Reiko Urade, Maho Yagi-Utsumi, Koichi Kato, Rina Hirano, Tomoya Kujirai, Hitoshi Kurumizaka, Masaaki Sugiyama  (2020)  Integral approach to biomacromolecular structure by analytical-ultracentrifugation and small-angle scattering ommunications Biology. DOI:10.1038/s42003-020-1011-4
Shoko Sato, Naoki Tanaka, Yasuhiro Arimura, Tomoya Kujirai, Hitoshi Kurumizaka (2020)  The N-terminal and C-terminal Halves of Histone H2A.Z Independently Function in Nucleosome Positioning and Stability Genes Cells. DOI:10.1111/gtc.12791
Hirotaka Takahashi, Satoshi Yamanaka, Shohei Kuwada, Kana Higaki, Kohki Kido, Yusuke Sato, Shuya Fukai, Fuminori Tokunaga, Tatsuya Sawasaki (2020)  A Human DUB Protein Array for Clarification of Linkage Specificity of Polyubiquitin Chain and Application to Evaluation of Its Inhibitors Biomedicines. 8 :6,  e152- DOI:10.3390/biomedicines8060152
Simon Miller, Yoshiki Aikawa, Akiko Sugiyama, Yoshiko Nagai, Aya Hara, Tsuyoshi Oshima, Kazuma Amaike, Steve A Kay, Kenichiro Itami, Tsuyoshi Hirota (2020)  An Isoform-Selective Modulator of Cryptochrome 1 Regulates Circadian Rhythms in Mammals cell chemical biology. DOI:10.1016/j.chembiol.2020.05.008
Teizo Asano, Masato Sano, Junko Takei, Yusuke Sayama, Mika K. Kaneko, and Yukinari Kato (2020)  Epitope Mapping of the Anti-Diacylglycerol Kinase Monoclonal Antibody DhMab-4 for Immunohistochemical Analysis Monoclonal Antibodies in Immunodiagnosis and Immunotherapy . DOI:10.1089/mab.2020.0012
Yukinari Kato , Tomokazu Ohishi , Masato Sano , Teizo Asano , Yusuke Sayama , Junko Takei , Manabu Kawada , Mika K Kaneko  (2020)  H 2 Mab-19 Anti-Human Epidermal Growth Factor Receptor 2 Monoclonal Antibody Therapy Exerts Antitumor Activity in Pancreatic Cancer Xenograft Models Monoclonal Antibodies in Immunodiagnosis and Immunotherapy . 39 :3,  61-65 DOI:10.1089/mab.2020.0011
Yukinari Kato, Masato Sano, Teizo Asano, Yusuke Sayama, and Mika K. Kaneko (2020)  Thr80 of Sheep Podoplanin Is a Critical Epitope of the Antisheep Podoplanin Monoclonal Antibody: PMab-256 Monoclonal Antibodies in Immunodiagnosis and Immunotherapy . 39 :3,  95-100 DOI:10.1089/mab.2020.0010
Yosuke Hashimoto, Keisuke Tachibana, Masuo Kondoh (2020)  Tight Junction Modulators for Drug Delivery to the Central Nervous System Drug Discovery Today. DOI:10.1016/j.drudis.2020.05.007
Yukinari Kato, Junko Takei, Masato Sano, Teizo Asano, Yusuke Sayama, Kazuyuki Uchida, Takayuki Nakagawa, Mika K Kaneko (2020)  Detection of Lion Podoplanin Using the Antitiger Podoplanin Monoclonal Antibody PMab-231 Monoclonal Antibodies in Immunodiagnosis and Immunotherapy . 39 :3,  91-94 DOI:10.1089/mab.2020.0008
Ryoki Nakamura, Tomohiro Numata, Go Kasuya, Takeshi Yokoyama, Tomohiro Nishizawa, Tsukasa Kusakizako, Takafumi Kato, Tatsuya Hagino, Naoshi Dohmae, Masato Inoue, Kengo Watanabe, Hidenori Ichijo, Masahide Kikkawa, Mikako Shirouzu, Thomas J Jentsch, Ryuichiro Ishitani, Yasunobu Okada, Osamu Nureki (2020)  Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation Communications Biology. 3 :1,  240- DOI:10.1038/s42003-020-0951-z
Kohki Kido, Satoshi Yamanaka, Shogo Nakano, Kou Motani, Souta Shinohara, Akira Nozawa, Hidetaka Kosako, Sohei Ito, Tatsuya Sawasaki_  (2020)  AirID, a novel proximity biotinylation enzyme, for analysis of protein-protein interactions eLife. 9 e54983- DOI:10.7554/eLife.54983
Hideo Fukuhara_ , Mwila Hilton Mwaba_ , Katsumi Maenaka_ (2020)  Structural Characteristics of Measles Virus Entry Current Opinion in Virology. 41 52-58 DOI:10.1016/j.coviro.2020.04.002
Goichi Akiyama, Sindhu Saraswathy, Thania Bogarin, Xiaojing Pan, Ernesto Barron. Tina T Wong, Mika K Kaneko, Yukinari Kato, Young Hong, Alex S Huang_  (2020)  Functional, Structural, and Molecular Identification of Lymphatic Outflow From Subconjunctival Blebs Experimental eye Research. 196 108049- DOI:10.1016/j.exer.2020.108049
Yukinari Kato, Yoshikazu Furusawa, Masato Sano, Junko Takei, Takuro Nakamura, Miyuki Yanaka, Saki Okamoto, Saori Handa, Yu Komatsu, Teizo Asano, Yusuke Sayama, and Mika K. Kaneko (2020)  Development of an Anti-Sheep Podoplanin Monoclonal Antibody PMab-256 for Immunohistochemical Analysis of Lymphatic Endothelial Cells Monoclonal Antibodies in Immunodiagnosis and Immunotherapy . DOI:10.1089/mab.2020.0005
Atsunori Oshima (2020)  Structural insights into gap junction channels boosted by cryo-EM Current Opinion in Structural Biology. 63 42-48 DOI:10.1016/j.sbi.2020.03.008
Hiroshi Manya , Naoyuki Kuwabara , Ryuichi Kato , Tamao Endo (2020)  FAM3B/PANDER-Like Carbohydrate-Binding Domain in a Glycosyltransferase, POMGNT1 Methods in molecular biology. 2132 609-619 DOI:10.1007/978-1-0716-0430-4_52
Shogo Miyoshi, Soh Tokunaga, Tatsuhiko Ozawa, Hiroyuki Takeda, Mitsuo Aono, Takanori Miyoshi, Hiroyuki Kishi,Atsushi Muraguchi, Shin-ichi Shimizu, Akira Nozawa , Tatsuya Sawasaki (2020)  Production of a rabbit monoclonal antibody for highly sensitive detection of citrus mosaic virus and related viruses Pathology International. 15 :4,  DOI:10.1371/journal.pone.0229196
Satoshi Shibata, Mikio Shoji, Kodai Okada, Hideyuki Matsunami, Melissa M. Matthews, Katsumi Imada, Koji Nakayama& Matthias Wolf_ (2020)  Structure of polymerized type V pilin reveals assembly mechanism involving protease-mediated strand exchange Nature Microbiology. 5 830-837 DOI:10.1038/s41564-020-0705-1
Shinji Yamada, Mika K. Kaneko, Yusuke Sayama, Teizo Asano, Masato Sano, Miyuki Yanaka, Takuro Nakamura, Saki Okamoto, Saori Handa, Yu Komatsu, Yoshimi Nakamura, Yoshikazu Furusawa, Junko Takei, and Yukinari Kato (2020)  Development of Novel Mouse Monoclonal Antibodies Against Human CD19 Monoclonal Antibodies in Immunodiagnosis and Immunotherapy . DOI:10.1089/mab.2020.0003
Chenjiang Liu, Yoshihiro Kobashigawa, Soichiro Yamauchi, Natsuki Fukuda, Takashi Sato, Takeshi Masuda, Sumio Ohtsuki, Hiroshi Morioka  (2020)  Convenient Method of Producing Cyclic Single-Chain Fv Antibodies by Split-Intein-Mediated Protein Ligation and Chaperone Co-Expression The Journal of Biochemistry. DOI:10.1093/jb/mvaa042
Yusuke Sayama, Masato Sano, Teizo Asano, Yoshikazu Furusawa, Junko Takei, Takuro Nakamura, Miyuki Yanaka, Saki Okamoto, Saori Handa, Yu Komatsu, Yoshimi Nakamura,Mikiko Yanagawa, Mika K. Kaneko, and Yukinari Kato (2020)  Epitope Mapping of PMab-241, a Lymphatic Endothelial Cell-Specific Anti-Bear Podoplanin Monoclonal Antibody Monoclonal Antibodies in Immunodiagnosis and Immunotherapy . DOI:10.1089/mab.2020.0004
Hiroki Tanaka, Shoko Sato,Masako Koyama, Tomoya Kujirai and Hitoshi Kurumizaka (2020)  Biochemical and structural analyses of the nucleosome containing human histone H2A.J The Journal of Biochemistry. 167 :4,  419-427 DOI:10.1093/jb/mvz109
Teizo Asano, Mika K Kaneko, Yukinari Kato (2020)  RIEDL tag: A novel pentapeptide tagging system for transmembrane protein purification Biochemistry and Biophysics Reports. 23 DOI:10.1016/j.bbrep.2020.100780
Manuel E. Otero-Ramirez, Kyoko Matoba, Emiko Mihara, Toby Passioura, Junichi Takagi, Hiroaki Suga (2020)  Macrocyclic peptides that inhibit Wnt signalling via interaction with Wnt3a RSC Chemical Biology . DOI:10.1039/D0CB00016G
Masataka Umitsu, Katsuya Sakai, Keiko Tamura-Kawakami, Kunio Matsumoto, Junichi Takagi  (2020)  The constitutive high-affinity Met-binding site in the kringle domain is dispensable for the signalling activity of hepatocyte growth factor Journal of Biochemistry. DOI:10.1093/jb/mvaa006
Kazumi Saikusa, Daiki Kato, Aritaka Nagadoi, Hitoshi Kurumizaka, Satoko Akashi (2020)  Native Mass Spectrometry of Protein and DNA Complexes Prepared in Nonvolatile Buffers. Journal of the American Society for Mass Spectrometry. 31 711-718 DOI:10.1021/jasms.9b00145.
TomoyaKujirai, HitoshiKurumizaka (2020)  Transcription through the nucleosome Current Opinion in Structural Biology . 61 42-49 DOI:10.1016/j.sbi.2019.10.007.
Risa Fujita, Tatsuro Yamamoto, Yasuhiro Arimura, Saori Fujiwara, Hiroaki Tachiwana, Yuichi Ichikawa, Yuka Sakata, Liying Yang, Reo Maruyama, Michiaki Hamada, Mitsuyoshi Nakao, Noriko Saitoh, Hitoshi Kurumizaka (2020)  Nucleosome destabilization by nuclear non-coding RNAs Communications Biology. 3 60- DOI:10.1038/s42003-020-0784-9
Yoshimasa Takizawa,_Cheng-Han Ho,_Hiroaki Tachiwana,_Hideyuki Matsunami,_Wataru Kobayashi,_Midori Suzuki,_Yasuhiro Arimura,_Tetsuya Hori,_Tatsuo Fukagawa,_Melanie D Ohi,_Matthias Wolf,_Hitoshi Kurumizaka (2020)  Cryo-EM Structures of Centromeric Tri-nucleosomes Containing a Central CENP-A Nucleosome Structure. 28 :1,  44-53 DOI:10.1016/j.str.2019.10.016
Assen Marintchev, Takuhiro Ito (2020)  eIF2B and the Integrated Stress Response: A Structural and Mechanistic View Biochemistry. 59 :13,  1299-1308 DOI:10.1021/acs.biochem.0c00132
Xi Jiang, Ashutosh Kumar, Yasutaka Motomura, Tian Liu, Yong Zhou, Kazuyo Moro, Kam Y. J. Zhang, Qing Yang (2020)  A series of compounds bearing a dipyrido-pyrimidine scaffold acting as novel human and insect pest chitinases inhibitors Journal of Medicinal Chemistry. 63 :3,  987-1001 DOI:10.1021/acs.jmedchem.9b01154
Eiko Seki, Tatsuo Yanagisawa, Mitsuo Kuratani, Kensaku Sakamoto, Shigeyuki Yokoyama (2020)  Fully Productive Cell-Free Genetic Code Expansion by Structure-Based Engineering of Methanomethylophilus alvus Pyrrolysyl-tRNA Synthetase ACS Synthetic Biology. 9 :4,  718-732 DOI:10.1021/acssynbio.9b00288
Satoshi Yamanaka, Yusuke Sato, Daisuke Oikawa, Eiji Goto, Shuya Fukai, Fuminori Tokunaga, Hirotaka Takahashi, Tatsuya Sawasaki (2020)  Subquinocin, a small molecule inhibitor of CYLD and USP-family deubiquitinating enzymes, promotes NF-κB signaling Biochemical and Biophysical Research Communications. 524 :1,  1-7 DOI:10.1016/j.bbrc.2019.12.049
Toshiko Yamazawa, Haruo Ogawa, Takashi Murayama, Maki Yamaguchi, Hideto Oyamada, Junji Suzuki, Nagomi Kurebayashi, Kazunori Kanemaru, Katsuji Oguchi, Takashi Sakurai, Masamitsu Iino (2020)  Insights into channel modulation mechanism of RYR1 mutants using Ca2+ imaging and molecular dynamics Journal of General Physiology. 152 e201812235- DOI:10.1085/jgp.201812235
Haruo Ogawa, Nagomi Kurebayashi, Toshiko Yamazawa & Takashi Murayama  (2020)  Regulatory mechanisms of ryanodine receptor/Ca2+ release channel revealed by recent advancements in structural studies Journal of Muscle Research and Cell Motility_. 375 DOI:10.1007/s10974-020-09575-6
Simon Miller, You Lee Son, Yoshiki Aikawa, Eri Makino, Yoshiko Nagai, Ashutosh Srivastava, Tsuyoshi Oshima, Akiko Sugiyama, Aya Hara, Kazuhiro Abe, Kunio Hirata, Shinya Oishi, Shinya Hagihara, Ayato Sato, Florence Tama, Kenichiro Itami, Steve A. Kay, Megumi Hatori & Tsuyoshi Hirota (2020)  Isoform-selective regulation of mammalian cryptochromes Nature Chemical Biology. DOI:10.1038/s41589-020-0505-1
Batuujin Burendei, Ruriko Shinozaki, Masakatsu Watanabe, Tohru Terada, Kazutoshi Tani, Yoshinori Fujiyoshi, Atsunori Oshima (2020)  Cryo-EM structures of undocked innexin-6 hemichannels in phospholipids Science Advances. 6 :7,  eaax3157- DOI:10.1126/sciadv.aax3157
Kotaro Koiwai, Kazue Inaba, Kana Morohashi, Sora Enya, Reina Arai, Hirotatsu Kojima, Takayoshi Okabe, Yuuta Fujikawa, Hideshi Inoue, Ryunosuke Yoshino, Takatsugu Hirokawa, Koichiro Kato, Kaori Fukuzawa, Yuko Shimada-Niwa, Akira Nakamura, Fumiaki Yumoto, Toshiya Senda and Ryusuke Niwa (2020)  An integrated approach unravels a crucial structural property required for the function of the insect steroidogenic Halloween protein Noppera-bo Journal of Biological Chemistry. DOI:10.1074/jbc.RA119.011463
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Rika Idogawa, Youngchan Kim, Ken Shimomori, Takamitsu Hosoya, Suguru Yoshida (2020)  Single C-F Transformations of o_Hydrosilyl Benzotrifluorides with Trityl Compounds as All-in-One Reagents Organic Letters. DOI:10.1021/acs.orglett.0c03529
Masanori Shigeno, Kazutoshi Hayashi, Kanako Nozawa-Kumada, Yoshinori Kondo (2020)  Catalytic C(sp2)-C(sp3) Bond Formation of Methoxyarenes by the Organic Superbase t_Bu-P4 Organic Letters. DOI:10.1021/acs.orglett.0c03507
Takumi Yasuno, Tomoyuki Ohe, Hiroki Kataoka, Kosho Hashimoto, Yumiko Ishikawa, Keigo Furukawa, Yasuhiro Tateishi, Toi Kobayashi, Kyoko Takahashi, Shigeo Nakamura, Tadahiko Mashino (2020)  Fullerene derivatives as dual inhibitors of HIV-1 reverse transcriptase and protease Bioorganic & Medicinal Chemistry Letters. DOI:10.1016/j.bmcl.2020.127675
Yoshitake Nishiyama, Kei Akiyama, Yuki Sakata, Takamitsu Hosoya, and Suguru Yoshida (2020)  Facile Synthesis of Tetraarylpyrazines by Sequential Cross-coupling Approach Chemistry Letters. DOI:10.1246/cl.200715
Norikazu Terashima, Yuki Sakata, Tomohiro Meguro, Takamitsu Hosoya, and Suguru Yoshida (2020)  Triazole formation of phosphinyl alkynes with azides through transient protection of phosphine by copper Chemical communications. DOI:10.1039/D0CC06551J
Yu Nakamura, Yuki Sakata, Takamitsu Hosoya, Suguru Yoshida  (2020)  Synthesis of Functionalized Benzopyran/Coumarin-Derived Aryne Precursors and Their Applications Organic Letters. DOI:10.1021/acs.orglett.0c03106
Takuya Kobayakawa, Kento Ebihara, Kohei Tsuji, Takuma Kawada, Masayuki Fujino, Yuzuna Honda, Nami Ohashi, Tsutomu Murakami, Hirokazu Tamamura (2020)  Bivalent HIV-1 fusion inhibitors based on peptidomimetics Bioorganic & Medicinal Chemistry. DOI:10.1016/j.bmc.2020.115812
Juri Sakata, Kazunari Akita, Manabu Sato, Masashi Shimomura, and Hidetoshi Tokuyama (2020)  Cyclic Sulfamidite as Simultaneous Protecting Group for Amino Alcohols: Development of a Mild Deprotection Protocol Using Thiophenol Chemical and Pharmaceutical Bulletin. 68 :10,  996-1000 DOI:10.1248/cpb.c20-00531
Yutaro Tsubono, Yusuke Kawamoto, Takuya Hidaka, Ganesh N Pandian, Kaori Hashiya, Toshikazu Bando, Hiroshi Sugiyama (2020)  A Near-Infrared Fluorogenic Pyrrole_Imidazole Polyamide Probe for Live-Cell Imaging of Telomeres Journal of the American chemical society. DOI:10.1021/jacs.0c04955
Takeshi Yasui, Tomohiro Kikuchi and Yoshihiko Yamamoto (2020)  Rhodium-catalyzed cycloisomerization of ester-tethered 1,6-diynes with cyclopropanol moiety leading to tetralone/exocyclic diene hybrid molecules chemical communications. DOI:10.1039/D0CC05429A.
Kei Yoshida, Kosuke Okada, Hirofumi Ueda, Hidetoshi Tokuyama (2020)  A Concise Enantioselective Total Synthesis of (_)-Deoxoapodine Angewandte Chemie International Edition . DOI:10.1002/anie.202010759
Tsubasa Matsuzawa, Takamitsu Hosoya and Suguru Yoshida (2020)  One-step synthesis of benzo[b]thiophenes by aryne reaction with alkynyl sulfides Chemical Science. DOI:10.1039/d0sc04450d
Naoaki Makio , Yuki Sakata , Tomoko Kuribara , Keisuke Adachi , Yasutomo Hatakeyama , Tomohiro Meguro , Kazunobu Igawa , Katsuhiko Tomooka , Takamitsu Hosoya and Suguru Yoshida (2020)  (Hexafluoroacetylacetonato)copper(I)_cycloalkyne complexes as protected cycloalkynes Chemical communications. DOI:10.1039/D0CC05182A.
Yuto Sumida, Ryu Harada, Tomoe Sumida, Kohei Johmoto, Hidehiro Uekusa, Takamitsu Hosoya  (2020)  Synthesis of Dibenzofurans by Cu-Catalyzed Deborylative Ring Contraction of Dibenzoxaborin Organic Letters. DOI:10.1021/acs.orglett.0c02584
Miyuki Yamaguchi, Ryoya Hagiwara, Kanami Gayama, Kohei Suzuki, Yusuke Sato, Hideyuki Konishi, and Kei Manabe (2020)  Direct C3-Selective Arylation of N-Unsubstituted Indoles with Aryl Chlorides, Triflates, and Nonaflates Using a Palladium_Dihydroxyterphenylphosphine Catalyst The Journal of Organic chemistry. DOI:10.1021/acs.joc.0c01494
Tsukasa Sawato ,Mieko Arisawa , and Masahiko Yamaguchi (2020)  Reversible Formation of Self-assembly Gels Containing Giant Vesicles in Trifluoromethylbenzene Using Oxymethylenehelicene Oligomers with Terminal C16 Alkyl Groups Bulletin of the Chemical Society of Japan. DOI:10.1246/bcsj.20200164
Noriyuki Natsume, Kaori Ozaki, Daisuke Nakajima, Satoshi Yokoshima, Toshiaki Teruya (2020)  Structure-Activity Relationship Study of Majusculamides A and B and Their Analogues on Osteogenic Activity Journal of Natural products. DOI:10.1021/acs.jnatprod.0c00441
Satoshi Yokoshima (2020)  Synthesis of Polycyclic Natural Products through Skeletal Rearrangement Synlett. 31 DOI:10.1055/s-0040-1707904
Satoshi Inouye, Mitsuhiro Nakamura, Jumpei Taguchi, Takamitsu Hosoya (2020)  Identification of a novel oxidation product from yellow fluorophore in the complex of apoPholasin and dehydrocoelenterazine Bioorganic & Medicinal Chemistry Letters. 30 :19,  DOI:10.1016/j.bmcl.2020.127435
Keisuke Adachi,Tomohiro Meguro, Yuki Sakata, Kazunobu Igawa, Katsuhiko Tomooka, Takamitsu Hosoya and Suguru Yoshida (2020)  Selective strain-promoted azide_alkyne cycloadditions through transient protection of bicyclo[6.1.0]nonynes with silver or gold Chemical Communications. DOI:10.1039/D0CC04606J
Rina Maeda, Shinji Ito, Kaori Hashiya, Toshikazu Bando, Hiroshi Sugiyama (2020)  DNA alkylation of the RUNX-binding sequence by CBI-PI polyamide comjugates Chemistry A European Journal. DOI:10.1002/chem.202002166
ShinyaFujii, ErikoKikuchi, YukoWatanabe, HonokaSuzuyama, MariIshigami-Yuasa, TakayasuMori, KiyoshiIsobe, ShinichiUchida, HiroyukiKagechika (2020)  Structural development of N-(4-phenoxyphenyl)benzamide derivatives as novel SPAK inhibitors blocking WNK kinase signaling Bioorganic & Medicinal Chemistry Letters. 30 :17,  DOI:10.1016/j.bmcl.2020.127408
Yumi Yamashita, Louna Poignant, Juri Sakata, and Hidetoshi Tokuyama  (2020)  Divergent Total Syntheses of Isobatzellines A/B and Batzelline A Organic Letters. DOI:10.1021/acs.orglett.0c01894
Hiromichi Egami, Ryo Hotta, Minami Otsubo, Taiki Rouno, Tomoki Niwa, Kenji Yamashita, and Yoshitaka Hamashima (2020)  Asymmetric Dearomatizing Fluoroamidation of Indole Derivatives with Dianionic Phase-Transfer Catalyst Organic Letters. DOI:10.1021/acs.orglett.0c02026
Kenji Watanabe, Nodoka Terao, Isao Kii, Reiko Nakagawa, Takashi Niwa , Takamitsu Hosoya (2020)  Indolizines Enabling Rapid Uncaging of Alcohols and Carboxylic Acids by Red Light-Induced Photooxidation Organic Letters. DOI:10.1021/acs.orglett.0c01799
Kanako Nozawa-Kumada, Yuki Iwakawa, So Onuma, Masanori Shigeno and Yoshinori Kondo (2020)  NaH-mediated direct C_H arylation in the presence of 1,10- phenanthroline Chemical Communications. DOI:10.1039/D0CC00730G
Yuya Tamura, Yasunori Minami, Yoshitake Nishiyama, Yuki Sakata, Fumika Karaki, Takamitsu Hosoya, Suguru Yoshida_ (2020)  Synthesis of Multisubstituted Cycloalkenes Through Carbomagnesiation of Strained Cycloalkynes Chemical communications. DOI:10.1039/d0cc02788j
Takuya Yoshida, Hiroya Oki, Michihiro Doi, Syohei Fukuda, Tomohiro Yuzuriha, Ryotaro Tabata, Kenji Ishimoto, Kazuki Kawahara, Tadayasu Ohkubo, Hiroyuki Miyachi, Takefumi Doi & Keisuke Tachibana  (2020)  Structural Basis for PPARα Activation by 1H-pyrazolo-[3,5-b]pyridine Derivatives Scientific Reports. 10 :1,  DOI:10.1038/s41598-020-64527-x
Kyosuke Ueda and Satoshi Yokoshima (2020)  Synthetic Studies on Densanins: Stereoselective Construction of a Pyrrolidine Ring Containing a Quaternary Carbon Heterocycles. 103 DOI:10.3987/COM - 20 - S(K)4
Akihiro Kobayashi, Tsubasa Matsuzawa, Takamitsu Hosoya, and Suguru Yoshida (2020)  One-pot Synthesis of Allyl Sulfides from Sulfinate Esters and Allylsilan through Reduction of Alkoxysulfonium Intermediates Chemistry Letters. DOI:10.1246/cl.200285
Haruka Murakami, Tomohiro Asakawa, Yoshihiro Muramatsu, Ryo Ishikawa, Aiki Hiza, Yuta Tsukaguchi, Yohei Tokumaru, Masahiro Egi, Makoto Inai, Hitoshi Ouchi, Fumihiko Yoshimura, Tohru Taniguchi, Yoshinobu Ishikawa, Mitsuru Kondo, and Toshiyuki Kan (2020)  Total Synthesis of Sophoraflavanone H and Con firmation of Its Absolute Configuration Organic Letters. 22 :10,  3820-3824 DOI:10.1021/acs.orglett.0c01063
Yusuke Miura , Hitoshi Ouchi , Makoto Inai , Taisei Osawa , Fumihiko Yoshimura , Junichiro Kanazawa , Masanobu Uchiyama, Mitsuru Kondo , Toshiyuki Kan (2020)  Synthetic Studies on Pactamycin: A Synthesis of Johnson's Intermediate Organic Letters. 22 :9,  3515-3518 DOI:10.1021/acs.orglett.0c00959
Yoshitake Nishiyama, Takamitsu Hosoya and Suguru Yoshida (2020)  Synthesis of benzyl sulfides via substitution reaction at the sulfur of phosphinic acid thioesters Chemical Communications. 56 :43,  5771-5774 DOI:10.1039/d0cc02039g
Kotaro Mutsuura ,Yuki Sakata ,Keisuke Uchida ,Takamitsu Hosoya , and Suguru Yoshida  (2020)  Synthesis of Thioxanthones through Formal C_H Thiolation of Benzoic Acid Esters and Acid-mediated Direct Cyclization Chemistry Letters. DOI:10.1246/cl.200190
Takayoshi Nakaoka, Yuta Uetake, Ken-ichi Kaneko, Takashi Niwa, Hidenori Ochiai, Satsuki Irie, Yoshie Suezaki, Natsumi Otsuka, Emi Hayashinaka, Yasuhiro Wada, Yilong Cui, Kazuya Maeda, Hiroyuki Kusuhara, Yuichi Sugiyama, Takamitsu Hosoya, and Yasuyoshi Watanabe (2020)  Practical Synthesis of [18F]Pitavastatin and Evaluation of Hepatobiliary Transport Activity in Rats by Positron Emission Tomography Molecular Pharmaceutics. DOI:10.1021/acs.molpharmaceut.9b01284
Michitaka Kurimoto, Daisuke Nakajima, Yoshitake Nishiyama, Satoshi Yokoshima (2020)  Semipinacol Rearrangement Induced by Cleavage of Dibromocyclopropane European journal of Organic Chemistry. DOI:10.1002/ejoc.202000355
Mieko Arisawa,___ Kohei Fukumoto_ and_ Masahiko Yamaguchi_ (2020)  Rhodium-catalyzed phosphorylation reaction of water-soluble disulfides using hypodiphosphoric acid tetraalkyl esters in water RSC Advances. 10 13820-13823 DOI:10.1039/d0ra02377a
KoheiTsuji, Kofi Baffour-AwuahOwusu,TakuyaKobayakawa,RongyiWang,MasayukiFujino, MoemiKaneko, NaokiYamamoto, TsutomuMurakami,HirokazuTamamura (2020)  Exploratory studies on CA-15L, an anti-HIV active HIV-1 capsid fragment Bioorganic & Medicinal Chemistry. 28 :11,  DOI:10.1016/j.bmc.2020.115488
Miyuki Yamaguchi, Kota Ogihara, Hideyuki Konishi, Kei Manabe (2020)  Synthesis of 2,3-disubstituted indoles from alkynylanilines and 2-chlorophenols using palladium_dihydroxyterphenylphosphine catalys Tetrahedron Letters. 61 :21,  DOI:10.1016/j.tetlet.2020.151896
Satoshi Inouye, Yuiko Miura-Sahara, Rie Iimori, Yuki Sakata, Yuki Hazama, Suguru Yoshida, Mitsuhiro Nakamura, Takamitsu Hosoya (2020)  A novel yellow fluorescent protein of recombinant apoPholasin with dehydrocoelenterazine Biochemical and Biophysical Research Communications. 526 :2,  404-409 DOI:10.1016/j.bbrc.2020.03.085
Youngchan Kim,_ Kazuya Kanemoto,_ Ken Shimomori,_ Takamitsu Hosoya,_ Suguru Yoshida (2020)  Functionalization of a Single C_F Bond of Trifluoromethylarenes Assisted by an ortho-Silyl Group Using a Trityl-Based All-in-One Reagent with Ytterbium Triflate Catalyst Chemistry _ A European Journal: List of Issues. DOI:10.1002/chem.202001315
SatoshiInouye, YuikoMiura-Sahara, RieIimoriYukiSakata, YukiHazama, SuguruYoshida, MitsuhiroNakamura, TakamitsuHosoya (2020)  A novel yellow fluorescent protein of recombinant apoPholasin with dehydrocoelenterazine Biochemical and Biophysical Research Communications. 526 :2,  404-409 DOI:10.1016/j.bbrc.2020.03.085
Tsuneyuki Kobayashi, Takamitsu Hosoya, Suguru Yoshida (2020)  Consecutive Aryne Generation Strategy for the Synthesis of 1,3-Diarylpyrazoles The Journal of Organic Chemistry. 85 :6,  4448-4462 DOI:10.1021/acs.joc.0c00172
Kazuya Kanemoto, Yuki Sakata, Takamitsu Hosoya, Suguru Yoshida (2020)  Synthesis of Phenoxathiins and Phenothiazines by Aryne Reactions with Thiosulfonates Chemistry Letters. DOI:10.1246/cl.200132
Tomohiro Meguro, Yuki Sakata, Takamoto Morita, Takamitsu Hosoya, Suguru Yoshida (2020)  Facile assembly of three cycloalkyne-modules onto a platform compound bearing thiophene S,S-dioxide moiety and two azido groups Chemical Comunications. DOI:10.1039/D0CC01810D
Takashi Niwa, Takamitsu Hosoya (2020)  Molecular Renovation Strategy for Expeditious Synthesis of Molecular Probes Bulletin of the Chemical Society of Japan. 93 :2,  230-248 DOI:10.1246/bcsj.20190310
Akihiro Shiogai, Tatsuya Toma, Satoshi Yokoshima (2020)  Synthetic Studies on Bilobalide Synlett. 31 :3,  290-294 DOI:10.1055/s-0039-1691559
Yoshihiko Yamamoto, Jiyue Jiang, Takeshi Yasui (2020)  Palladium‐Catalyzed [3+2] and [2+2+2] Annulations of 4‐Iodo‐2‐quinolones with Activated Alkynes through Selective C-H Activation Chemistry A European Journal. 26 :17,  3749-3757 DOI:10.1002/chem.201904558
Shoutaro Iwase, Yusuke Suzuki, Shinji Tanaka, Masato Kitamura (2020)  CpRu/Br_nsted Acid-Catalyzed Enantioselective Dehydrative Cyclization of Pyrroles N-Tethered with Allylic Alcohols Organic Letters. 22 :5,  1929-1933 DOI:10.1021/acs.orglett.0c00290
Keigo Murakami, Tatsuya Toma, Tohru Fukuyama, Satoshi Yokoshima (2020)  Total Synthesis of Tetrodotoxin Angewandte Chemie. DOI:10.1002/ange.201916611
Keisuke Tachibana, Masuo Kondoh (2020)  A Method to Prepare Claudin-Modulating Recombinant Proteins Methods in Molecular Biology. 2109 251-260 DOI:10.1007/7651_2019_258
Mieko Arisawa, Ren Suzuki, Keiichiro Ohashi, Masahiko Yamaguchi (2020)  Rhodium-catalyzed Synthesis of Heteroarylselenyl Esters from Diheteroaryl Diselenides and Acid Fluorides Asian Journal of Organic Chemistry. DOI:10.1002/ajoc.202000077
Mieko Arisawa, Katsuya Nakai, Tomoki Yamada, Ren Suzuki, Masahiko Yamaguchia (2020)  Synthesis of cycloalkyl/steroidal heteroaryl sulfides using rhodium-catalyzed heteroaryl exchange reaction Heterocycles. 100 :1,  104-118 DOI:10.3987/COM-19-14147
Yuichi Onda, Kazuki Fukushi, Kosuke Ohsawa, Masahito Yoshida, Yuichi Masuda, Takayuki Doi (2020)  Synthesis of a Biphenylalanine Analogue of Apratoxin A Displaying Substantially Enhanced Cytotoxicity Heterocycles. 101 :2,  679-691 DOI:10.3987/COM-19-S(F)35
Masashi Shimomura, Manabu Sato, Hiroki Azuma, Juri Sakata, Hidetoshi Tokuyama (2020)  Total Synthesis of (-)-Lepadiformine A via Radical Translocation_Cyclization Reaction Organic Letters. DOI:10.1021/acs.orglett.0c00474
Yasuhiro Tateishi, Tomoyuki Ohe, Daisuke Yasuda, Kyoko Takahashi, Shigeo Nakamura, Yasuhiro Kazuki, Tadahiko Mashino_ (2020)  Synthesis and evaluation of nevirapine analogs to study the metabolic activation of nevirapine Drug Metabolism and Pharmacokinetics. 35 :2,  238-243 DOI:10.1016/j.dmpk.2020.01.006
Daisuke Yasuda, Tomoyuki Ohe, Kyoko Takahashi, Riyo Imamura, Hirotatsu Kojima, Takayoshi Okabe, Yoshinobu Ichimura, Masaaki Komatsu, Masayuki Yamamoto, Tetsuo Nagano, Tadahiko Mashino (2020)  Inhibitors of the protein_protein interaction between phosphorylated p62 and Keap1 attenuate chemoresistance in a human hepatocellular carcinoma cell line Free Radical Research. DOI:10.1080/10715762.2020.1732955
Wakako Kuribayashi, Motohiko Oshima, Naoki Itokawa, Shuhei Koide, Yaeko Nakajima-Takagi, Masayuki Yamashita, Satoshi Yamazaki, Bahityar Rahmutulla, Fumihito Miura, Takashi Ito, Atsushi Kaneda, Atsushi Iwama (2020)  Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche Journal of Experimental medicine. 218 DOI:10.1084/jem.20192283
Yohei Inai, Takeshi Izawa, Mutsuki Mori, Machi Atarashi, Seiichirou Tsuchiya, Mitsuru Kuwamura, Jyoji Yamate (2020)  Analyses of Hemorrhagic Diathesis in High-Iron Diet-Fed Rats Journal of Toxicologic Pathology. DOI:10.1293/tox.2020-0004
Yuhei Sangatsuda, Fumihito Miura, Hiromitsu Araki, Masahiro Mizoguchi, Nobuhiro Hata, Daisuke Kuga, Ryusuke Hatae, Yojiro Akagi, Takeo Amemiya, Yutaka Fujioka, Yasuhito Arai, Akihiko Yoshida, Tatsuhiro Shibata, Koji Yoshimoto, Koji Iihara & Takashi Ito  (2020)  Base_resolution methylomes of gliomas bearing histone H3.3 mutations reveal a G35 mutant_specific signature shared with bone tumors Scientific Reports. 10 DOI:10.1038/s41598-020-73116-x
Nahid Rahman, Mizuki Kuramochi, Takeshi Izawa, Mitsuru Kuwamura, Jyoji Yamate (2020)  Characterization of Immature Myofibroblasts of Stellate Cell or Mesenchymal Cell Origin in D-Galactosamine-Induced Liver Injury in Rats Veterinary Pathology. DOI:10.1177/0300985820963097
Ryoji Ito, Ikumi Katano, Iyo Otsuka, Takeshi Takahashi, Hiroshi Suemizu, Mamoru Ito and Peter J. Simons (2020)  Bovine β-lactoglobulin-induced passive systemic anaphylaxis model using humanized NOG hIL-2/hGM-CSF transgenic mice international immunology. :9,  DOI:10.1093/intimm/dxaa067
Mutsuki Mori, Takeshi Izawa, Yohei Inai, Sho Fujiwara, Ryo Aikawa, Mitsuru Kuwamura and Jyoji Yamate (2020)  Dietary Iron Overload Differentially Modulates Chemically-Induced Liver Injury in Rats nutrients. 12 DOI:10.3390/nu12092784
Yuhei Sangatsuda, Fumihito Miura, Hiromitsu Araki, Masahiro Mizoguchi, Nobuhiro Hata, Daisuke Kuga, Ryusuke Hatae, Yojiro Akagi, Takeo Amemiya, Yutaka Fujioka, Yasuhito Arai, Akihiko Yoshida, Tatsuhiro Shibata, Koji Yoshimoto, Koji Iihara, Takashi Ito (2020)  Base_resolution methylomes of gliomas bearing histone H3.3 mutations reveal a G34 mutant_specific signature shared with bone tumors Scientific Reports. 10 DOI:10.1038/s41598-020-73116-x
Mutsuki Mori, Takeshi Izawa * , Yohei Inai, Sho Fujiwara, Ryo Aikawa, Mitsuru Kuwamura and Jyoji Yamate (2020)  Dietary Iron Overload Di erentially Modulates Chemically-Induced Liver Injury in Rats nutrients. DOI:10.3390/nu12092784
Yumi Ohta, Kanako Kazuki, Satoshi Abe, Mitsuo Oshimura, Kaoru Kobayashi, Yasuhiro Kazuki (2020)  Development of Caco-2 cells expressing four CYPs via a mammalian artificial chromosome BMC Biotechnology. 20 DOI:10.1186/s12896-020-00637-8
Noa HADA, Mizuki KURAMOCHI, Takeshi IZAWA, Mitsuru KUWAMURA, Jyoji YAMATE (2020)  Effects of dexamethasone on hepatic macrophages in normal livers and thioacetamide-induced acute liver lesions in rats Journal of Toxicologic Pathology. DOI:10.1293/tox.2020-0016
Takako Ohyama, Hazuki Takahashi, Harshita Sharma, Toshio Yamazaki, Stefano Gustincich, Yoshitaka Ishii, Piero Carninci (2020)  An NMR-based approach reveals the core structure of the functional domain of SINEUP lncRNAs Nucleic acids research. DOI:10.1093/nar/gkaa598
Shinya Tanaka, Wataru Ise, Takeshi Inoue, Ayako Ito, Chisato Ono, Yoshihito Shima, Shuhei Sakakibara, Manabu Nakayama, Kentaro Fujii, Ikuo Miura, Jafar Sharif, Haruhiko Koseki, Pandelakis A. Koni, Indu Raman, Quan-Zhen Li, Masato Kubo, Katsunori Fujiki, Ryuichiro Nakato, Katsuhiko Shirahige, Hiromitsu Araki, Fumihito Miura, Takashi Ito, Eiryo Kawakami, Yoshihiro Baba& Tomohiro Kurosaki_ (2020)  Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity nature immunology. :1,  7083- DOI:10.1038/s41590-020-0700-y
Miki Yamazaki_ , Masahito Hosokawa_ , Koji Arikawa_ , Kiyofumi Takahashi_ , Chikako Sakanashi_ , Takuya Yoda_ , Hiroko Matsunaga_ , Haruko Takeyama (2020)  Efective microtissue RNA extraction coupled with Smart-seq2 for reproducible and robust spatial transcriptome analysis Scientific Reports. 10 :5,  1088- DOI:10.1038/s41598-020-63495-6
Takuro Horii_ , Ryosuke Kobayashi_ , Mika Kimura_ , Sumiyo Morita_ , Izuho Hatada_  (2020)  Calcium-Free and Cytochalasin B Treatment Inhibits Blastomere Fusion in 2-Cell Stage Embryos for the Generation of Floxed Mice via Sequential Electroporation cells. 9 :1,  7083- DOI:10.3390/cells9051088
Miki Yamazaki_ , Masahito Hosokawa_ , Koji Arikawa_ , Kiyofumi Takahashi , Chikako Sakanashi, Takuya Yoda , Hiroko Matsunaga , Haruko Takeyama (2020)  Effective Microtissue RNA Extraction Coupled With Smart-seq2 for Reproducible and Robust Spatial Transcriptome Analysis Scientific Reports. 10 DOI:10.1038/s41598-020-63495-6
Takuro Horii, Sumiyo Morita, Shinjiro Hino, Mika Kimura, Yuko Hino, Hiroshi Kogo, Mitsuyoshi Nakao & Izuho Hatada_ (2020)  Successful generation of epigenetic disease model mice by targeted demethylation of the epigenome Genome Biology. 21 DOI:10.1186/s13059-020-01991-8
Yamazaki M, Hosokawa M, Arikawa K, Takahashi K, Sakanashi C, Yoda T, Matsunaga H, Takeyama H (2020)  Effective microtissue RNA extraction coupled with Smart-seq2 for reproducible and robust spatial transcriptome analysis Scientific Reports. 10 7083- DOI:10.1038/s41598-020-63495-6
Hayato Tsuyuzaki, Masahito Hosokawa, Koji Arikawa, Takuya Yoda, Naoyuki Okada, Haruko Takeyama, Masamitsu Sato (2020)  Time-lapse single-cell transcriptomics reveals modulation of histone H3 for dormancy breaking in fission yeast Nature communications. 11 :2,  207-210 DOI:10.1038/s41467-020-15060-y
Shuichi Otani, Shohei Miki, Yuta Nakamura, Kenji Ishimoto, Yukio Ago, Shinsaku Nakagawa. (2020)  Improved Bioavailability of b-Carotene by Amorphous Solid Dispersion Technology in Rats. Journal of Nutritional Science and Vitaminology . 66 :3,  509-523 DOI:10.3177/jnsv.66.207
Ai Hashimoto, Mohammad Rabiul Karim, Mizuki Kuramochi, Takeshi Izawa, Mitsuru Kuwamura, Jyoji Yamate (2020)  Characterization of Macrophages and Myofibroblasts Appearing in Dibutyltin Dichloride_Induced Rat Pancreatic Fibrosis Toxicologic Pathology. 48 :4,  560-569 DOI:10.1177/0192623319893310
Hironobu Nishina, Chisa Katou-Ichikawa, Mizuki Kuramochi, Takeshi Izawa, Mitsuru Kuwamura, Jyoji Yamate (2020)  Participation of Somatic Stem Cells, Recognized by a Unique A3 Antibody, in Mucosal Epithelial Regeneration in Dextran Sulfate Sodium (DSS)_Induced Rat Colonic Lesions Toxicologic Pathology. 48 :2,  238-243 DOI:10.1177/0192623320906817
YasuhiroTateishi, TomoyukiOhe, DaisukeYasuda, KyokoTakahashi, ShigeoNakamura, YasuhiroKazuki, TadahikoMashino (2020)  Synthesis and evaluation of nevirapine analogs to study the metabolic activation of nevirapine. Drug Metab Pharmacokinet. 35 111914- DOI:10.1016/j.dmpk.2020.01.006
Takashi Moriwaki, Satoshi Abe, Mitsuo Oshimura, Yasuhiro Kazuki (2020)  Transchromosomic technology for genomically humanized animals Experimental Cell Research. :1,  77-77 DOI:10.1016/j.yexcr.2020.111914
Takuro Horii, Sumiyo Morita, Shinjiro Hino, Mika Kimura, Yuko Hino, Hiroshi Kogo, Mitsuyoshi Nakao, Izuho Hatada (2020)  Successful generation of epigenetic disease model mice by targeted demethylation of the epigenome Genome Biology. 21 :5,  1574- DOI:10.1186/s13059-020-01991-8
Sumiyo Morita, Takuro Horii, Mika Kimura, Izuho Hatada (2020)  Synergistic Upregulation of Target Genes by TET1 and VP64 in the dCas9_SunTag Platform International Journal of Molecular Sciences. 21 :1,  58-70 DOI:10.3390/ijms21051574
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