BINDS - 創薬等先端技術支援基盤プラットフォーム

Kenta Ujifuku, Takashi Fujimoto, Kei Sato, Yoichi Morofuji, Hideki Muto, Hiroshi Masumoto, Shinsuke Nakagawa, Masami Niwa, Takayuki Matsuo (2020) Exploration of Pericyte‑Derived Factors Implicated in Lung Cancer Brain Metastasis Protection: A Pilot Messenger RNA Sequencing Using the Blood–Brain Barrier In Vitro Model Cellular and Molecular Neurobiology. DOI:10.1007/s10571-020-00988-y

MaoIsono, WakakoFuruyama, MakotoKuroda, TatsunariKondoh, ManabuIgarashi, MasahiroKajihara, ReikoYoshida, RashidManzoor, KosukeOkuya, HirokoMiyamoto, HeinzFeldmann, AndreaMarzi, MasahiroSakaitani, AsukaNanbo, AyatoTakada (2020) A biaryl sulfonamide derivative as a novel inhibitor of filovirus infection Antiviral Research. 183 DOI:10.1016/j.antiviral.2020.104932

Keisuke Tachibana , Masuo Kondoh (2020) A Method to Prepare a Bioprobe for Regulatory Science of the Drug Delivery System to the Brain: An Angulin Binder to Modulate Tricellular Tight Junction-Seal Methods in Molecular Biology. DOI:10.1007/7651_2020_317

Hiroshi Manya , Naoyuki Kuwabara , Ryuichi Kato , Tamao Endo (2020) FAM3B/PANDER-Like Carbohydrate-Binding Domain in a Glycosyltransferase, POMGNT1 Methods in molecular biology. 2132 609-619 DOI:10.1007/978-1-0716-0430-4_52

Hiroki Yamaguchi, Akiko Kamegawa, Kunio Nakata, Tatsuki Kashiwagi, Yoshinori Fujiyoshi, Kazutoshi Tani, Toshimi Mizukoshi (2020) Leucine Dehydrogenase: Structure and Thermostability Sub-cellular biochemistry. DOI:10.1007/978-3-030-58971-4_10

Rie Koga, Mami Yamamoto, Takahiro Kosugi, Naohiro Kobayashi, Toshihiko Sugiki, Toshimichi Fujiwara, Nobuyasu Koga (2020) Robust folding of a de novo designed ideal protein even with most of the core mutated to valine Proceedings of the National Academy of Sciences of the United States of America. DOI:10.1073/pnas.2002120117

Koki Makabe, Ruka Hirota, Yoshihito Shiono, Yoshikazu Tanaka, Takuya Koseki (2020) Biochemical and structural 1 investigation of rutinosidase from Aspergillus oryzae Applied and Environmental Microbiology. DOI:10.1128/AEM.02438-20

Kentaro Ihara, Masakatsu Hato, Takanori Nakane, Keitaro Yamashita, Tomomi Kimura-Someya, Toshiaki Hosaka, Yoshiko Ishizuka-Katsura, Rie Tanaka, Tomoyuki Tanaka, Michihiro Sugahara, Kunio Hirata, Masaki Yamamoto, Osamu Nureki, Kensuke Tono, Eriko Nango, So Iwata, Mikako Shirouzu (2020) Isoprenoid_chained lipid EROCOC17+ 4: a new matrix for membrane protein crystallization and a crystal delivery medium in serial femtosecond crystallography Scientific Reports. 10 DOI:10.1038/s41598-020-76277-x

Kazuaki Matoba, Tetsuya Kotani, Akihisa Tsutsumi, Takuma Tsuji, Takaharu Mori, Daisuke Noshiro, Yuji Sugita, Norimichi Nomura, So Iwata, Yoshinori Ohsumi, Toyoshi Fujimoto, Hitoshi Nakatogawa, Masahide Kikkawa, Nobuo N Noda (2020) Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion nature structural & molecular biology. DOI:10.1038/s41594-020-00518-w

Hua Lu, Takayuki Nakamuro, Keitaro Yamashita, Haruaki Yanagisawa, Osamu Nureki, Masahide Kikkawa, Han Gao, Jiangwei Tian, Rui Shang, Eiichi Nakamura (2020) B/N-Doped p_Arylenevinylene Chromophores: Synthesis, Properties, and Microcrystal Electron Crystallographic Study Jouenal of the American Chemical Society. DOI:10.1021/jacs.0c10337

Toshiyuki Oda, Haruaki Yanagisawa (2020) Cryo-electron tomography of cardiac myofibrils reveals a 3D lattice spring within the Z-discs Communications biology. 3 DOI:10.1038/s42003-020-01321-5

Shingo Tojo, Zhikuan Zhang, Hiroyuki Matsui, Masahiro Tahara, Mitsunori Ikeguchi, Mami Kochi, Mami Kamada, Hideki Shigematsu, Akihisa Tsutsumi, Naruhiko Adachi, Takuma Shibata, Masaki Yamamoto, Masahide Kikkawa, Toshiya Senda, Yoshiaki Isobe, Umeharu Ohto, Toshiyuki Shimizu (2020) Structural analysis reveals TLR7 dynamics underlying antagonism 11 DOI:10.1038/s41467-020-19025-z

Kazutoshi Tani, Ryo Kanno, Yuki Makino, Malgorzata Hall, Mizuki Takenouchi, Michie Imanishi, Long-Jiang Yu, J_rg Overmann, Michael T Madigan, Yukihiro Kimura, Akira Mizoguchi, Bruno M Humbel, Zheng-Yu Wang-Otomo (2020) Cryo-EM structure of a Ca2+-bound photosynthetic LH2-RC complex containing multiple αβ-polypeptides nature communications. :11, DOI:10.1038/s41467-020-18748-3

Kazutoshi Tani, Ryo Kanno, Yuki Makino, Malgorzata Hall, Mizuki Takenouchi, Michie Imanishi, Long-Jiang Yu, J_rg Overmann, Michael T Madigan, Yukihiro Kimura, Akira Mizoguchi, Bruno M Humbel, Zheng-Yu Wang-Otomo (2020) Cryo-EM structure of a Ca2+-bound photosynthetic LH1-RC complex containing multiple αβ-polypeptides nature communications. :11, DOI:10.1038/s41467-020-18748-3

Hanayo Nakanishi, Tomohiro Nishizawa, Katsumori Segawa, Osamu Nureki, Yoshinori Fujiyoshi, Shigekazu Nagata, Kazuhiro Abe (2020) Transport Cycle of Plasma Membrane Flippase ATP11C by Cryo-EM Cell reports. 32 :13, DOI:10.1016/j.celrep.2020.108208

Satoshi Fukuhara, Kazuhiro Kobayashi, Tsukasa Kusakizako, Wataru Iida, Kato Masahiko, Wataru Shihoya, Osamu Nureki (2020) Structure of the human secretin receptor coupled to an engineered heterotrimeric G protein Biochemical and Biophysical Research Communications. DOI:10.1016/j.bbrc.2020.08.042

Satoshi Murakami, Ui Okada, Hendrik W. van Veen (2020) Tripartite transporters as mechano‐transmitters in periplasmic alternating‐access mechanisms FEBS letters. DOI:10.1002/1873-3468.13929

Tatsuki Tanaka, Manish Singh, Wataru Shihoya, Keitaro Yamashita, Hideki Kandori, Osamu Nureki (2020) Structural basis for unique color tuning mechanism in heliorhodopsin Biochemical and Biophysical Research Communications. DOI:10.1016/j.bbrc.2020.06.124

Akiyuki Taruno1,2 & Kengo Nomura1 & Tsukasa Kusakizako3 & Zhongming Ma & Osamu Nureki & J. Kevin Foskett (2020) Taste transduction and channel synapses in taste buds Pfl_gers Archiv - European Journal of Physiology. DOI:10.1007/s00424-020-02464-4

Hirotake Furihata, Satoshi Yamanaka, Toshiaki Honda, Yumiko Miyauchi, Atsuko Asano, Norio Shibata, Masaru Tanokura, Tatsuya Sawasaki, Takuya Miyakawa (2020) Structural bases of IMiD selectivity that emerges by 6-hydroxythalidomide nature communications. DOI:10.1038/s41467-020-18488-4

Tomoya Kujirai, Christian Zierhut, Yoshimasa Takizawa, Ryan Kim, Lumi Negishi, Nobuki Uruma, Seiya Hirai, Hironori Funabiki, Hitoshi Kurumizaka (2020) Structural basis for the inhibition of cGAS by nucleosomes Science . DOI:10.1126/science.abd0237

Norimasa Iwanami, Divine-Fondzenyuy Lawir, Katarzyna Sikora, Connor O Meara, Kohei Takeshita, Michael Schorpp, Thomas Boehm (2020) Transgenerational inheritance of impaired larval Tcell development in zebrafish nature communications. 11 DOI:10.1038/s41467-020-18289-9

Masatoshi Maeki, Sho Ito, Reo Takeda, Go Ueno, Akihiko Ishida, Hirofumi Tani, Masaki Yamamoto and Manabu Tokeshi (2020) Room-temperature crystallography using a microfluidic protein crystal array device and its application to protein_ligand complex structure analysis Chemical Science. DOI:10.1039/D0SC02117b

Hiroki Tanaka, Yoshimasa Takizawa , Motoki Takaku , Daiki Kato , Yusuke Kumagawa , Sara A Grimm, Paul A Wade, Hitoshi Kurumizaka (2020) Interaction of the pioneer transcription factor GATA3 with nucleosomes nature communications. 11 DOI:10.1038/s41467-020-17959-y

Jun-Ichi Kishikawa, Atsuko Nakanishi, Aya Furuta, Takayuki Kato, Keiichi Namba, Masatada Tamakoshi, Kaoru Mitsuoka, Ken Yokoyama (2020) Mechanical inhibition of isolated Vo from V/A-ATPase for proton conductance eLife. 9 e56862- DOI:10.7554/eLife.56862

Riki Imaizumi,_ Ryo Mameda,_ Kohei Takeshita,_ Hiroki Kubo,_ Naoki Sakai,_ Shun Nakata,_ Seiji Takahashi,_ Kunishige Kataoka_ Masaki Yamamoto,_ Toru Nakayama,_ Satoshi Yamashita,_ Toshiyuki Waki (2020) Crystal structure of chalcone synthase, a key enzyme for isoflavonoid biosynthesis in soybean proteins. DOI:10.1002/prot.25988

Honjie Li, Yoshiki Nakajima, Takashi Nomura,Michihiro Sugahara, Shinichiro Yonekura, Siu Kit Chan, Takanori Nakane, Takahiro Yamane, Yasufumi Umena, Mamoru Suzuki, Tetsuya Masuda, Taiki Motomura, Hisashi Naitow, Yoshinori Matsuura, Tetsunari Kimura, Kensuke Tono, Shigeki Owada, Yasumasa Joti, Rie Tanaka, Eriko Nango, Fusamichi Akita, Minoru Kubo, So Iwata, Jian-Ren Shen, Michihiro Suga (2020) Capturing structural changes of photosystem II using time-resolved serial femtosecond crystallography with proper flash excitations _Nature Research journal. DOI:10.21203/rs.3.rs-41101/v1

Kenta Echigoya, Masako Koyama, Lumi Negishi, Yoshimasa Takizawa, Yuka Mizukami, Hideki Shimabayashi, Akari Kuroda, Hitoshi Kurumizaka (2020) Nucleosome binding by the pioneer transcription factor OCT5 Scientific Reports. 10 DOI:10.1038/s41598-020-68850-1

Takaaki Hikima (2020) BL45XU(RIKEN Structural Biology I) RIKEN Beamlines.

Hiroto Shimada, Tsukasa Kusakizako, T. H. Dung Nguyen, Tomohiro Nishizawa, Tomoya Hino, Makoto Tominaga & Osamu Nureki_ (2020) The structure of lipid nanodisc-reconstituted TRPV3 reveals the gating mechanism nature structural & molecular biology. DOI:10.1038/s41594-020-0439-z

Simon Miller, Yoshiki Aikawa, Akiko Sugiyama, Yoshiko Nagai, Aya Hara, Tsuyoshi Oshima, Kazuma Amaike, Steve A Kay, Kenichiro Itami, Tsuyoshi Hirota (2020) An Isoform-Selective Modulator of Cryptochrome 2 Regulates Circadian Rhythms in Mammals cell chemical biology. DOI:10.1016/j.chembiol.2020.05.008

Rina C Sakata, Soh Ishiguro, Hideto Mori, Mamoru Tanaka, Kenji Tatsuno, Hiroki Ueda, Shogo Yamamoto, Motoaki Seki, Nanami Masuyama, Keiji Nishida, Hiroshi Nishimasu, Kazuharu Arakawa, Akihiko Kondo, Osamu Nureki_, Masaru Tomita, Hiroyuki Aburatani , Nozomu Yachie (2020) Base Editors for Simultaneous Introduction of C-to-T and A-to-G Mutations Nature Biotechnology. DOI:10.1038/s41587-020-0509-0

Ryo Nagao, Koji Kato, Kentaro Ifuku, Takehiro Suzuki, Minoru Kumazawa, Ikuo Uchiyama, Yasuhiro Kashino, Naoshi Dohmae, Seiji Akimoto, Jian-Ren Shen, Naoyuki Miyazaki, Fusamichi Akita (2020) Structural Basis for Assembly and Function of a Diatom Photosystem I-light-harvesting Supercomplex Nature Communications. 11 2481- DOI:10.1038/s41467-020-16324-3

Kenta Okamoto , Ricardo J Ferreira , Daniel S D Larsson , Filipe R N C Maia , Haruhiko Isawa, Kyoko Sawabe , Kazuyoshi Murata , Janos Hajdu, Kenji Iwasaki_ , Peter M Kasson , Naoyuki Miyazaki_ (2020) Acquired Functional Capsid Structures in Metazoan Totivirus-like dsRNA Virus Structure. DOI:10.1016/j.str.2020.04.016

Fusamichi Akita, Ryo Nagao, Koji Kato, Yoshiki Nakajima, Makio Yokono, Yoshifumi Ueno, Takehiro Suzuki, Naoshi Dohmae. Jian-Ren Shen, Seiji Akimoto, Naoyuki Miyazaki_ (2020) Structure of a Cyanobacterial Photosystem I Surrounded by Octadecameric IsiA Antenna Proteins Communications Biology. 3 :1, - DOI:10.1038/s42003-020-0949-6

Taro Masuda , Seiki Baba , Koichi Matsuo , Shinji Ito , Bunzo Mikami_ (2020) The High-Resolution Crystal Structure of Lobster Hemocyanin Shows Its Enzymatic Capability as a Phenoloxidase Archives of Biochemistry and Biophysics . 688 108370- DOI:10.1016/j.abb.2020.108370.

Hiroshi Iijima, Katsuki Takebe, Mamoru Suzuki, Hiroko Kobayashi, TomokoTakamiya, Hiroaki Saito, Norio Niwa, and Takao Kuwada-Kusunose (2020) Crystal Structure of Catechol O-Methyltransferase Complexed with Nitecapone Chemical and Pharmaceutical Bulletin. 68 :5, 447-451 DOI:10.1248/cpb.c20-00011

Tsuneyuki Kobayashi, Takamitsu Hosoya, and Suguru Yoshida (2020) Aryne Reaction and Cross-Coupling Approach for the Synthesis of Diverse N-Arylphenylalanine Derivatives Chemistry Letters. DOI:10.1246/cl.200276

Chenjiang Liu, Yoshihiro Kobashigawa, Soichiro Yamauchi, Natsuki Fukuda, Takashi Sato, Takeshi Masuda, Sumio Ohtsuki , Hiroshi Morioka_ (2020) Convenient Method of Producing Cyclic Single-Chain Fv Antibodies by Split-Intein-Mediated Protein Ligation and Chaperone Co-Expression The Journal of Biochemistry. DOI:10.1093/jb/mvaa042

Hiroyoshi Hamada ,Takayuki Nakamuro ,Keitaro Yamashita ,Haruaki Yanagisawa ,Osamu Nureki , Masahide Kikkawa ,Koji Harano ,Rui Shang , and Eiichi Nakamura (2020) Spiro-conjugated Carbon/Heteroatom-bridged p-Phenylenevinylenes: Synthesis, Properties, and Microcrystal Electron Crystallographic Analysis of Racemic Solid Solutions Bulletin of the Chemical Society of Japan. DOI:10.1246/bcsj.20200065

Minghao Chen, Masato Ishizaka, Shun Narai, Masaki Horitani, Naoki Shigi, Min Yao & Yoshikazu Tanaka (2020) The [4Fe-4S] cluster of sulfurtransferase TtuA desulfurizes TtuB during tRNA modification in Thermus thermophilus Communications Biology. 3 :1, DOI:10.1038/s42003-020-0895-3

Rafaella Stepanova, Hayato Inagi, Kei Sugawara, Kazuya Asada, Tomoyuki Nishi,DaijiroUeda, Yoko Yasuno, Tetsuro Shinada, Kunio Miki, Masahiro Fujihashi, and Tsutomu Sato (2020) Characterization of Class IB terpene synthase: thefirst crystalstructurebound with substrate surrogate ACS Chemical Biology. DOI:10.1021/acschembio.0c00145

KengoKitadokoro, MutsumiTanaka, takaakiHikima, YukikoOkuno, MasakiYamamoto & ShigekiKamitani (2020) Crystal structure of pathogenic Staphylococcus aureuslipase complex with theanti-obesity drug orlistat Scientific Reports. 10 :1, DOI:10.1038/s41598-020-62427-8

Mao Oide, Takayuki Kato, Tomotaka Oroguchi & Masayoshi Nakasako (2020) Energy landscape of domain motion in glutamate dehydrogenase deduced from cryo-electron microscopy. The FEBS Journal. DOI:10.1111/febs.15224

Tomoko Yamaguchi, Shoko Toma, Naoya Terahara, Tomoko Miyata, Masamichi Ashihara, Tohru Minamino, Keiichi Namba, Takayuki Kato (2020) Structural and Functional Comparison of Salmonella Flagellar Filaments Composed of FljB and FliC Bimolecules. 10 :2, 246- DOI:10.3390/biom10020246

Yurika Yamada, Keiichi Namba & Takashi Fujii (2020) Cardiac muscle thin filament structures reveal calcium regulatory mechanism Nature Communications. 11 153- DOI:10.1038/s41467-019-14008-1

Hiroyuki Terashima, Chinatsu Tatsumi, Akihiro Kawamoto, Keiichi Namba, Tohru Minamino, and Katsumi Imada (2020) In Vitro Autonomous Construction of the Flagellar Axial Structure in Inverted Membrane Vesicles Biomolecules. 10 :1, 126- DOI:10.3390/biom10010126

Batuujin Burendei, Ruriko Shinozaki, Masakatsu Watanabe, Tohru Terada, Kazutoshi Tani, Yoshinori Fujiyoshi, and Atsunori Oshima (2020) Cryo-EM structures of undocked innexin-6 hemichannels in phospholipids Science Advances. 6 eaax3157- DOI:10.1126/sciadv.aax3157

Yuichi Yokoyama, Tohru Terada, Kentaro Shimizu, Kouki Nishikawa, Daisuke Kozai, Atsuhiro Shimada, Akira Mizoguchi, Yoshinori Fujiyoshi, Kazutoshi Tani (2020) Development of a deep learning-based method to identify “good” regions of a cryo-electron microscopy grid Biophysical Reviews. DOI:10.1007/s12551-020-00669-6

Masahiko Okuda and Yoshifumi Nishimura (2020) The Eaf3 chromodomain acts as a pH sensor for gene expression by altering its binding affinity for histone methylated-lysine residues. Bioscience Reports . 40 :2, DOI:10.1042/BSR20191958.

Hidetsugu Asada, Asuka Inoue, Francois Marie Ngako Kadji, Kunio Hirata, Yuki Shiimura, Dohyun Im, Tatsuro Shimamura, Norimichi Nomura, Hiroko Iwanari, Takao Hamakubo, Osamu Kusano-Arai, Hiromi Hisano, Tomoko Uemura, Chiyo Suno, Junken Aoki, So Iwata, (2020) The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone Structure. 28 :4, 418-425 DOI:10.1016/j.str.2019.12.003

Rie Umeda, Yuhkoh Satouh, Mizuki Takemoto, Yoshiko Nakada-Nakura, Kehong Liu, Takeshi Yokoyama, Mikako Shirouzu, So Iwata, Norimichi Nomura, Ken Sato, Masahito Ikawa, Tomohiro Nishizawa& Osamu Nureki_ (2020) Structural insights into tetraspanin CD9 function Nature Communications. 11 :1, 1606- DOI:10.1038/s41467-020-15459-7

Yasunori Watanabe, Yasushi Tamura, Chika Kakuta, Seiya Watanabe and Toshiya Endo (2020) Structural basis for interorganelle phospholipid transport mediated by VAT-1 Journal of Biological Chemistry. 295 :10, 3257-3268 DOI:10.1074/jbc.RA119.011019

Yoshizawa, Takuya; Fujita, Junso; Terakado, Haruna; Ozawa, Mayuki; Kuroda, Natsuko; Tanaka, Shun-ichi; Uehara, Ryo; Matsumura, Hiroyoshi; (2020) Crystal structures of the cell-division protein FtsZ from Klebsiella pneumoniae and Escherichia coli Acta Crystallographica Section F: Structural Biology Communications. 76 :2, 86-93 DOI:10.1107/S2053230X2000076X

Masakazu Sugishima, Kei Wada, Keiichi Fukuyama and Ken Yamamoto (2020) Crystal structure of phytochromobilin synthase in complex with biliverdin IXα, a key enzyme in the biosynthesis of phytochrome Journal of Biological Chemistry. 295 :3, 771-782 DOI:10.1074/jbc.RA119.011431

TamakiIzume, HirotakeMiyauch, iWataruShihoya, OsamuNureki (2020) Crystal structure of human endothelin ETB receptor in complex with sarafotoxin S6b Biochemical and Biophysical Research Communications. DOI:10.1016/j.bbrc.2019.12.091

Elin Claesson, Weixiao Yuan Wahlgren, Heikki Takala, Suraj Pandey, Leticia Castillon, Valentyna Kuznetsova, L_ocadie Henry, Matthijs Panman, Melissa Carrillo, Joachim K_bel, Rahul Nanekar, Linn_a Isaksson, Amke Nimmrich, Andrea Cellini, Dmitry Morozov, Micha_ Maj, Moona Kurttila, Robert Bosman, Eriko Nango, Rie Tanaka, Tomoyuki Tanaka, Luo Fangjia, So Iwata, Shigeki Owada, Keith Moffat, Gerrit Groenhof, Emina A. Stojkovi_, Janne A. Ihalainen, Marius Schmidt, Sebastian Westenhoff__ (2020) The primary structural photoresponse of phytochrome proteins captured by a femtosecond X-ray laser eLife. 9 e53514- DOI:10.7554/eLife.53514

Yuichi Mishima_ Laura Brueckner_ Saori Takahashi_ Toru Kawakami_ Junji Otani_ Akira Shinohara_ Kohei Takeshita_ Ronald Garingalao Garvilles_ Mikio Watanabe_ Norio Sakai_ Hideyuki Takeshima_ Charlotte Nachtegael_ Atsuya Nishiyama_ Makoto Nakanishi_ Kyohei Arita_ Kinichi Nakashima_ Hironobu Hojo_ Isao Suetake (2020) Enhanced processivity of Dnmt1 by monoubiquitinated histone H3. Gene to Cells. 25 :1, 22-32 DOI:10.1111/gtc.12732

Kengo Kitadokoro, Mutsumi Tanaka, Takaaki Hikima, Yukiko Okuno, Masaki Yamamoto, Shigeki Kamitani (2020) Crystal structure of pathogenic Staphylococcus aureus lipase complex with the anti-obesity drug orlistat Scientific Reports. 10 5469- DOI:10.1038/s41598-020-62427-8

Hironori Murakami, Kazuya Hasegawa, Go Ueno, Naoto Yagi, Masaki Yamamoto, and Takashi Kumasaka, (2020) Development of SPACE-II for rapid sample exchange at SPring-8 macromolecular crystallography beamlines Acta Crystallographica Section D. D76 155-165 DOI:10.1107/S2059798320000030

Ryosuke Nakamura_ Masahide Hikita_ Shoko Ogawa_ Yasuhiro Takahashi_ Takashi Fujishiro (2020) Snapshots of PLP-substrate and PLP-product external aldimines as intermediates in two types of cysteine desulfurase enzymes. FEBS Journal. 287 :6, 1138-1154 DOI:10.1111/febs.15081

Tomohiko Hayashi, Satoshi Yasuda, Kano Suzuki, Tomoki Akiyama, Kanae Kanehara, Keiichi Kojima, Mikio Tanabe, Ryuichi Kato, Toshiya Senda, Yuki Sudo, Takeshi Murata, Masahiro Kinoshita (2020) How Does a Microbial Rhodopsin RxR Realize Its Exceptionally High Thermostability with the Proton-Pumping Function Being Retained? The Journal of Physical Chemistry B. 124 :6, 990-1000 DOI:10.1021/acs.jpcb.9b10700

Kenji Ite, Kento Yonezawa, Kenichi Kitanishi, Nobutaka Shimizu, Masaki Unno (2020) Optimal Mutant Model of Human S100A3 Protein Citrullinated at Arg51 by Peptidylarginine Deiminase Type III and Its Solution Structural Properties ACS Omega. 5 :8, 4032-4042 DOI:10.1021/acsomega.9b03618

Afifa Ayu Koesoema, Daron M. Standley, Toshiya Senda, Tomoko Matsuda (2020) Impact and relevance of alcohol dehydrogenase enantioselectivities on biotechnological applications Applied Micribiology and Biotechnology. 104 2897-2909 DOI:10.1007/s00253-020-10440-2

Naoyuki Kuwabara, Rieko Imae, Hiroshi Manya, Tomohiro Tanaka, Mamoru Mizuno, Hiroki Tsumoto, Motoi Kanagawa, Kazuhiro Kobayashi, Tatsushi Toda, Toshiya Senda, Tamao Endo, Ryuichi Kato (2020) Crystal structures of fukutin-related protein (FKRP), a ribitol-phosphate transferase related to muscular dystrophy Nature Communications. 11 303- DOI:10.1038/s41467-019-14220-z

N_ra Taricska, D_niel Horv_th, D_ra K. Menyh_rd, Hanna _kontz-Kiss, Masahiro Noji, Masatomo So, Yuji Goto, Toshimichi Fujiwara and Andr_s Perczel (2020) The route from the folded to the amyloid state: exploring the potential energy surface of a drug-like miniprotein Chemistry a European Journal. 26 1968-1978 DOI:10.1002/chem.201905180

YoheiMiyanoiri, MitsuhiroTakeda, TsutomuTerauchi, MasatsuneKainoshobe (2020) Recent developments in isotope-aided NMR methods for supramolecular protein complexes _SAIL aromatic TROSY Biochimica et Biophysica Acta (General Subjects),. 1864 :2, DOI:10.1016/j.bbagen.2019.129439

Toshihiko Sugiki, Yoshihiro Yamaguchi, Toshimichi Fujiwara, Masayori Inouye, Yutaka Ito, Chojiro Kojima (2020) In-cell NMR as a Sensitive Tool to Monitor Physiological Condition of Escherichia Coli Scientific Reports. 10 2466- DOI:10.1038/s41598-020-59076-2

Koji Kato, Toshiyuki Shinoda, Ryo Nagao, Seiji Akimoto, Takehiro Suzuki, Naoshi Dohmae, Min Chen, Suleyman I. Allakhverdiev, Jian-Ren Shen, Fusamichi Akita, Naoyuki Miyazaki, Tatsuya Tomo (2020) Structural basis for the adaptation and function of chlorophyll f in photosystem I Nature Communications. 1 238- DOI:10.1038/s41467-019-13898-5

Masafumi Tanaka, Hisayasu Miyake, Satoko Oka, Shintaro Maeda. Kenji Iwasaki. Takahiro Mukai (2020) Effects of charged lipids on the physicochemical and biological properties of lipid_styrene maleic acid copolymer discoidal particles Biochimica et Biophysica Acta Biomembranes. 1862 :5, 183209- DOI:10.1016/j.bbamem.2020.183209

Tomohito Yamada, Toru Yoshida, Akihiro Kawamoto, Kaoru Mitsuoka, Kenji Iwasaki, Hideaki Tsuge (2020) Cryo-EM structures reveal translocational unfolding in the clostridial binary iota toxin complex Nature Structural Molecular Biology. 27 288-296 DOI:10.1038/s41594-020-0388-6

Sandra Huber, Anina B_r, Selina Epp, Jacqueline Schmuckli-Maurer, Naja Eberhard, Bruno M. Humbel, Andrew Hemphill, Kerry Woods (2020) Recruitment of Host Nuclear Pore Components to the Vicinity of Theileria Schizonts mSphere. 5 e00709-719 DOI:10.1128/mSphere.00709-19.

Hamazaki N, Kyogoku H, Araki H, Miura F, Horikawa C, Hamada N, Shimamoto S, Hikabe O, Nakashima K, Kitajima TS, Ito T, Leitch HG, Hayashi K. (2020) Reconstitution of the oocyte transcriptional network with transcription factors. Nature. :online ahead of print., DOI:10.1038/s41586-020-3027-9 PMID:33328630

YUSUKE SAYAMA, MIKA K. KANEKO and YUKINARI KATO (2020) Development and characterization of TrMab_6, a novel anti_TROP2 monoclonal antibody for antigen detection in breast cancer Molecular medicine reports. 23 :2, DOI:10.3892/mmr.2020.11731

Satoshi Kamoto, Masahiro Shinada, Daiki Kato, Sho Yoshimoto, Namiko Ikeda, Masaya Tsuboi, Ryohei Yoshitake, Shotaro Eto, Yuko Hashimoto, Yosuke Takahashi, James Chambers, Kazuyuki Uchida, Mika K Kaneko, Naoki Fujita, Ryohei Nishimura, Yukinari Kato, Takayuki Nakagawa (2020) Phase I/II Clinical Trial of the Anti-Podoplanin Monoclonal Antibody Therapy in Dogs with Malignant Melanoma Cells. 11 E2529- DOI:10.3390/cells9112529

Nasir K Bashiruddin, Mikihito Hayashi, Masanobu Nagano, Yan Wu, Yukiko Matsunaga, Junichi Takagi, Tomoki Nakashima, Hiroaki Suga (2020) Development of cyclic peptides with potent in vivo osteogenic activity through RaPID-based affinity maturation Proceedings of the National Academy of Sciences of the United States of America. DOI:10.1073/pnas.2012266117

Kentaro Ihara, Masakatsu Hato, Takanori Nakane, Keitaro Yamashita, Tomomi Kimura-Someya, Toshiaki Hosaka, Yoshiko Ishizuka-Katsura, Rie Tanaka, Tomoyuki Tanaka, Michihiro Sugahara, Kunio Hirata, Masaki Yamamoto, Osamu Nureki, Kensuke Tono, Eriko Nango, So Iwata, Mikako Shirouzu (2020) Isoprenoid_chained lipid EROCOC17+ 5: a new matrix for membrane protein crystallization and a crystal delivery medium in serial femtosecond crystallography Scientific Reports. 10 DOI:10.1038/s41598-020-76277-x

Yoshimi Shimizu, Takehiro Shinoda, Yoshitaka Shirasago, Masuo Kondoh, Naoko Shinya, Kentaro Hanada, Kiyohito Yagi, Tetsuro Suzuki, Takaji Wakita, Tomomi Kimura-Someya, Mikako Shirouzu, Masayoshi Fukasawa (2020) Occludin-binding single-chain variable fragment and antigen-binding fragment antibodies prevent hepatitis C virus infection FEBS letters. DOI:10.1002/1873-3468.13975

Kazutaka Murayama, Miyuki Kato-Murayama, Yuka Itoh, Kohei Miyazono, Keiji Miyazawa, Mikako Shirouzu (2020) Structural basis for inhibitory effects of Smad7 on TGF-β family signaling Journal of Structural Biology. DOI:10.1016/j.jsb.2020.107661

Yoshimi Shimizu, Takehiro Shinoda, Yoshitaka Shirasago, Masuo Kondoh, Naoko Shinya, Kentaro Hanada, Kiyohito Yagi, Tetsuro Suzuki, Takaji Wakita, Tomomi Kimura-Someya, Mikako Shirouzu, Masayoshi Fukasawa (2020) Occludin-binding single-chain variable fragment and antigen-binding fragment antibodies prevent hepatitis C virus infection FEBS Lertters. DOI:10.1002/1873-3468.13975

Kazuaki Matoba, Tetsuya Kotani, Akihisa Tsutsumi, Takuma Tsuji, Takaharu Mori, Daisuke Noshiro, Yuji Sugita, Norimichi Nomura, So Iwata, Yoshinori Ohsumi, Toyoshi Fujimoto, Hitoshi Nakatogawa, Masahide Kikkawa, Nobuo N Noda (2020) Atg10 is a lipid scramblase that mediates autophagosomal membrane expansion nature structural & molecular biology. DOI:10.1038/s41594-020-00518-w

Hideki Hosono Tomokazu Ohishi Junko Takei Teizo Asano Yusuke Sayama Manabu Kawada Mika K. Kaneko Yukinari Kato (2020) The anti_epithelial cell adhesion molecule (EpCAM) monoclonal antibody EpMab_16 exerts antitumor activity in a mouse model of colorectal adenocarcinoma Oncology Letters. DOI:10.3892/ol.2020.12246

Mika K Kaneko, Tomokazu Ohishi, Takuro Nakamura, Hiroyuki Inoue, Junko Takei, Masato Sano, Teizo Asano, Yusuke Sayama, Hideki Hosono, Hiroyoshi Suzuki, Manabu Kawada, Yukinari Kato (2020) Development of Core-Fucose-Deficient Humanized and Chimeric Anti-Human Podoplanin Antibodies Monoclonal Antibodies in Immunodiagnosis and Immunotherapy . 39 :5, DOI:10.1089/mab.2020.0019

Chan-I Chung, Yuko Sato, Yuki Ohmuro-Matsuyama, Shinichi Machida, Hitoshi Kurumizaka, Hiroshi Kimura, Hiroshi Ueda (2020) Intrabody-based FRET probe to visualize endogenous histone acetylation Scientific Reports. 9 DOI:10.1038/s41598-019-46573-2

Satoshi Arai, Shintaro Maruyama, Mitsunori Shiroishi, Ichiro Yamato, Takeshi Murata (2020) An affinity change model to elucidate the rotation mechanism of V1- ATPase Biochemical and Biophysical Research Communications. DOI:10.1016/j.bbrc.2020.10.033

MIKA K. KANEKO, TOMOKAZU OHISHI, JUNKO TAKEI, MASATO SANO,TAKURO NAKAMURA, HIDEKI HOSONO, MIYUKI YANAKA, TEIZO ASANO, YUSUKE SAYAMA, HIROYUKI HARADA, MANABU KAWADA andYUKINARI KATO (2020) Anti_EpCAM monoclonal antibody exerts antitumor activity against oral squamous cell carcinomas ONCOLOGY REPORTS. DOI:10.3892/or.2020.7808

Mika K. Kaneko, Tomokazu Ohishi, Manabu Kawada, Yukinari Kato (2020) A cancer-specific anti-podocalyxin monoclonal antibody (60-mG2a-f) exerts antitumor effects in mouse xenograft models of pancreatic carcinoma Biochemistry and Biophysics Reports. 24 DOI:10.1016/j.bbrep.2020.100826

Emiko Mihara, Satoshi Watanabe, Nasir Bashiruddin, Nozomi Nakamura, Kyoko Matoba, Rumit Maini, Yizhen Yin, Katsuya Sakai, Takao Arimori, Kunio Matsumoto, Hiroaki Suga, Junichi Takagi (2020) Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins chemical Biology. DOI:10.21203/rs.3.rs-85705/v1

Hisashi Yoshida, Sam-Yong Park, Gyosuke Sakashita, Yuko Nariai, Kanako Kuwasako, Yutaka Muto, Takeshi Urano, Eiji Obayashi (2020) Elucidation of the aberrant 3′ splice site selection by cancer-associated mutations on the U2AF2 nature communications. 11 DOI:10.1038/s41467-020-18559-6

Satoshi Yamanaka, Yuki Shoya, Saya Matsuoka, Hisayo Nishida-Fukuda, Norio Shibata, Tatsuya Sawasaki (2020) An IMiD-induced SALL4 degron system for selective degradation of target proteins comunications biology. 3 DOI:10.1038/s42003-020-01240-5

Kazumi Saikusa, Haruna Hidaka, Shunsuke Izumi, Satoko Akashi (2020) Mass spectrometric characterization of histone H3 isolated from in-vitro reconstituted and acetylated nucleosome core particle massspectrometry advace publication. DOI:10.5702/massspectrometry.A0090

Hirotake Furihata, Satoshi Yamanaka, Toshiaki Honda, Yumiko Miyauchi, Atsuko Asano, Norio Shibata, Masaru Tanokura, Tatsuya Sawasaki, Takuya Miyakawa (2020) Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide nature communications. DOI:10.1038/s41467-020-18488-4

Tomoya Kujirai, Christian Zierhut, Yoshimasa Takizawa, Ryan Kim, Lumi Negishi, Nobuki Uruma, Seiya Hirai, Hironori Funabiki, Hitoshi Kurumizaka (2020) Structural basis for the inhibition of cGAS by nucleosomes Science . DOI:10.1126/science.abd0237

Satoshi Ogasawara, Kano Suzuki, Kentaro Naruchi, Seiwa Nakamura, Junpei Shimabukuro, Nanase Tsukahara, Mika K. Kaneko, Yukinari Kato, Takeshi Murata (2020) Crystal structure of an anti-podoplanin antibody bound to a disialylated O-linked glycopeptide Biochemical and Biophysical Research Communications. DOI:10.1016/j.bbrc.2020.08.103

MasatoSano, TeizoAsano, Mika K.Kaneko, YukinariKato (2020) Epitope mapping of an anti-diacylglycerol kinase delta monoclonal antibody DdMab-1 Biochemistry and Biophysics Reports. 24 DOI:10.1016/j.bbrep.2020.100808

Tetsuya Handa, Akihito Harada, Kazumitsu Maehara, Shoko Sato, Masaru Nakao, Naoki Goto, Hitoshi Kurumizaka, Yasuyuki Ohkawa, Hiroshi Kimura (2020) Chromatin integration labeling for mapping DNA-binding proteins and modifications with low input Nature protocols. DOI:10.1038/s41596-020-0375-8

Yuki Shiimura , Shoichiro Horita , Akie Hamamoto , Hidetsugu Asada , Kunio Hirata , Misuzu Tanaka , Kenji Mori , Tomoko Uemura , Takuya Kobayashi , So Iwata , Masayasu Kojima (2020) Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode nature communications. 11 DOI:10.1038/s41467-020-17554-1

Hiroaki Tanabe, Yoshifumi Fujii, Miki Okada-Iwabu, Masato Iwabu, Kuniyuki Kano, Hiroki Kawana, Masakatsu Hato, Yoshihiro Nakamura, Takaho Terada, Tomomi Kimura-Someya, Mikako Shirouzu, Yoshiaki Kawano, Masaki Yamamoto, Junken Aoki, Toshimasa Yamauchi, Takashi Kadowaki, Shigeyuki Yokoyama (2020) Human adiponectin receptor AdipoR1 assumes closed and open structures Communications biology. 3 :1, DOI:10.1038/s42003-020-01160-4

_Junko Takei, Mika K. Kaneko, Tomokazu Ohishi, Hideki Hosono, Takuro Nakamura, Miyuki Yanaka, Masato Sano, Teizo Asano, Yusuke Sayama, Manabu Kawada, Hiroyuki Harada, Yukinari Kato (2020) A defucosylated anti_CD44 monoclonal antibody 5_mG2a_f exerts antitumor effects in mouse xenograft models of oral squamous cell carcinoma OncologyReports. DOI:10.3892/or.2020.7735

Naoe Kaneko, Mie Kurata, Toshihiro Yamamoto, Tomonari Shigemura, Kazunaga Agematsu, Takashi Yamazaki, Hiroyuki Takeda, Tatsuya Sawasaki, Tomohiro Koga, Atsushi Kawakami, Akihiro Yachie, Kiyoshi Migita, Koh-Ichiro Yoshiura, Takeshi Urano, Junya Masumoto (2020) KN3014, a piperidine_containing small compound, inhibits auto_secretion of IL_1β from PBMCs in a patient with Muckle_Wells syndrome Scientific Reports. 10 DOI:10.1038/s41598-020-70513-0

Hideki Hosono, Junko Takei, Tomokazu Ohishi, Masato Sano, Teizo Asano, Yusuke Sayama, Takuro Nakamura, Miyuki Yanaka, Manabu Kawada, Hiroyuki Harada, Mika Kato Kaneko, Yukinari Kato (2020) Anti_EGFR monoclonal antibody 134_mG2a exerts antitumor effects in mouse xenograft models of oral squamous cell carcinoma International Journal of Molecular Medicine . 46 :4, DOI:10.3892/ijmm.2020.4700

Tomoya Fujita, Takeshi Yokoyama, Mikako Shirouzu, Hideki Taguchi, Takuhiro Ito, and Shintaro Iwasaki (2020) Anatomy of footprint extension in ribosome profiling reveals translational landscape mediated by S1 protein in bacteria Biological science /Biochemistry. DOI:10.21203/rs.3.rs-41219/v1

Koki Ikeda, Shota Suzuki, Yoshiki Shigemitsu, Takeshi Tenno, Natsuko Goda, Atsunori Oshima, Hidekazu Hiroaki (2020) Presence of intrinsically disordered proteins can inhibit the nucleation phase of amyloid fibril formation of Aβ(1_42) in amino acid sequence independent manner Scientific Reports. 10 DOI:10.1038/s41598-020-69129-1

Kenta Echigoya, Masako Koyama, Lumi Negishi, Yoshimasa Takizawa, Yuka Mizukami, Hideki Shimabayashi, Akari Kuroda, Hitoshi Kurumizaka (2020) Nucleosome binding by the pioneer transcription factor OCT4 Scientific Reports. 10 DOI:10.1038/s41598-020-68850-1

Masahiro Nishimura, Yasuhiro Arimura, Kayo Nozawa, Hitoshi Kurumizaka (2020) Linker DNA and histone contributions in nucleosome binding by p53 The Journal of Biochemistry. DOI:10.1093/jb/mvaa081

Christoph Gerle (2020) Mitochondrial F-ATP synthase as the permeability transition pore Pharmacological Research. 160 DOI:10.1016/j.phrs.2020.105081

Mika K Kaneko, Masato Sano, Junko Takei, Teizo Asano, Yusuke Sayama, Hideki Hosono, Atsushi Kobayashi, Satoru Konnai, Yukinari Kato (2020) Development and Characterization of Anti-Sheep Podoplanin Monoclonal Antibodies PMab-253 and PMab-260 Monoclonal Antibodies in Immunodiagnosis and Immunotherapy . DOI:10.1089/mab.2020.0018

Yoshikazu Furusawa, Mika K Kaneko, Yukinari Kato (2020) Establishment of an Anti-CD20 Monoclonal Antibody(C20Mab-60) for Immunohistochemical Analyses Monoclonal Antibodies in Immunodiagnosis and Immunotherapy . DOI:10.1089/mab.2020.0015

Kenta Echigoya, Masako Koyama, Lumi Negishi, Yoshimasa Takizawa, Yuka Mizukami, Hideki Shimabayashi, Akari Kuroda, Hitoshi Kurumizaka (2020) Nucleosome binding by the pioneer transcription factor OCT4 Scientific Reports. 10 DOI:10.1038/s41598-020-68850-1

Masato Sano, Mika K. Kaneko, and Yukinari Kato (2020) Epitope Mapping of DhMab-1:An Antidiacylglycerol Kinase Monoclonal Antibody Monoclonal Antibodies in Immunodiagnosis and Immunotherapy . 39 DOI:10.1089/mab.2020.0014

Yoshikazu Furusawa, Mika Kato Kaneko, Yukinari Kato (2020) Establishment of C20Mab_11, a novel anti_CD20 monoclonal antibody, for the detection of B cells Oncology Letters. 20 1961-1967 DOI:10.3892/ol.2020.11753

Shinya, Goto; Satoru, Konnai; Yuki, Hirano; Junko, Kohara; Tomohiro, Okagawa; Naoya, Maekawa; Yamato, Sajiki; Kei, Watari; Erina, Minato; Atsuhi, Kobayashi; Satoshi, Gondaira; Hidetoshi, Higuchi; Masateru, Koiwa; Motoshi, Tajima; Eiji, Taguchi; Masaru, Ishida; Ryoko, Uemura; Shinji, Yamada; Mika, K. Kaneko; Yukinari, Kato; Keiichi, Yamamoto; Mikihiro, Toda; Yasuhiko, Suzuki; Shiro, Murata; Kazuhiko, Ohashi (2020) Clinical efficacy of the combined treatment of anti-PD-L1 rat-bovine chimeric antibody with a COX-2 inhibitor in calves infected with Mycoplasma bovis Japanese Journal of Veterinary Research. 68 :2, 77-90 DOI:10.14943/jjvr.68.2.77

Ken Morishima, Aya Okuda, Rintaro Inoue, Nobuhiro Sato, Yosuke Miyamoto, Reiko Urade, Maho Yagi-Utsumi, Koichi Kato, Rina Hirano, Tomoya Kujirai, Hitoshi Kurumizaka, Masaaki Sugiyama (2020) Integral approach to biomacromolecular structure by analytical-ultracentrifugation and small-angle scattering ommunications Biology. DOI:10.1038/s42003-020-1011-4

Shoko Sato, Naoki Tanaka, Yasuhiro Arimura, Tomoya Kujirai, Hitoshi Kurumizaka (2020) The N-terminal and C-terminal Halves of Histone H2A.Z Independently Function in Nucleosome Positioning and Stability Genes Cells. DOI:10.1111/gtc.12791

Hirotaka Takahashi, Satoshi Yamanaka, Shohei Kuwada, Kana Higaki, Kohki Kido, Yusuke Sato, Shuya Fukai, Fuminori Tokunaga, Tatsuya Sawasaki (2020) A Human DUB Protein Array for Clarification of Linkage Specificity of Polyubiquitin Chain and Application to Evaluation of Its Inhibitors Biomedicines. 8 :6, e152- DOI:10.3390/biomedicines8060152

Simon Miller, Yoshiki Aikawa, Akiko Sugiyama, Yoshiko Nagai, Aya Hara, Tsuyoshi Oshima, Kazuma Amaike, Steve A Kay, Kenichiro Itami, Tsuyoshi Hirota (2020) An Isoform-Selective Modulator of Cryptochrome 1 Regulates Circadian Rhythms in Mammals cell chemical biology. DOI:10.1016/j.chembiol.2020.05.008

Teizo Asano, Masato Sano, Junko Takei, Yusuke Sayama, Mika K. Kaneko, and Yukinari Kato (2020) Epitope Mapping of the Anti-Diacylglycerol Kinase Monoclonal Antibody DhMab-4 for Immunohistochemical Analysis Monoclonal Antibodies in Immunodiagnosis and Immunotherapy . DOI:10.1089/mab.2020.0012

Yukinari Kato , Tomokazu Ohishi , Masato Sano , Teizo Asano , Yusuke Sayama , Junko Takei , Manabu Kawada , Mika K Kaneko (2020) H 2 Mab-19 Anti-Human Epidermal Growth Factor Receptor 2 Monoclonal Antibody Therapy Exerts Antitumor Activity in Pancreatic Cancer Xenograft Models Monoclonal Antibodies in Immunodiagnosis and Immunotherapy . 39 :3, 61-65 DOI:10.1089/mab.2020.0011

Yukinari Kato, Masato Sano, Teizo Asano, Yusuke Sayama, and Mika K. Kaneko (2020) Thr80 of Sheep Podoplanin Is a Critical Epitope of the Antisheep Podoplanin Monoclonal Antibody: PMab-256 Monoclonal Antibodies in Immunodiagnosis and Immunotherapy . 39 :3, 95-100 DOI:10.1089/mab.2020.0010

Yosuke Hashimoto, Keisuke Tachibana, Masuo Kondoh (2020) Tight Junction Modulators for Drug Delivery to the Central Nervous System Drug Discovery Today. DOI:10.1016/j.drudis.2020.05.007

Yukinari Kato, Junko Takei, Masato Sano, Teizo Asano, Yusuke Sayama, Kazuyuki Uchida, Takayuki Nakagawa, Mika K Kaneko (2020) Detection of Lion Podoplanin Using the Antitiger Podoplanin Monoclonal Antibody PMab-231 Monoclonal Antibodies in Immunodiagnosis and Immunotherapy . 39 :3, 91-94 DOI:10.1089/mab.2020.0008

Ryoki Nakamura, Tomohiro Numata, Go Kasuya, Takeshi Yokoyama, Tomohiro Nishizawa, Tsukasa Kusakizako, Takafumi Kato, Tatsuya Hagino, Naoshi Dohmae, Masato Inoue, Kengo Watanabe, Hidenori Ichijo, Masahide Kikkawa, Mikako Shirouzu, Thomas J Jentsch, Ryuichiro Ishitani, Yasunobu Okada, Osamu Nureki (2020) Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation Communications Biology. 3 :１, 240- DOI:10.1038/s42003-020-0951-z

Kohki Kido, Satoshi Yamanaka, Shogo Nakano, Kou Motani, Souta Shinohara, Akira Nozawa, Hidetaka Kosako, Sohei Ito, Tatsuya Sawasaki_ (2020) AirID, a novel proximity biotinylation enzyme, for analysis of protein-protein interactions eLife. 9 e54983- DOI:10.7554/eLife.54983

Hideo Fukuhara_ , Mwila Hilton Mwaba_ , Katsumi Maenaka_ (2020) Structural Characteristics of Measles Virus Entry Current Opinion in Virology. 41 52-58 DOI:10.1016/j.coviro.2020.04.002

Goichi Akiyama, Sindhu Saraswathy, Thania Bogarin, Xiaojing Pan, Ernesto Barron. Tina T Wong, Mika K Kaneko, Yukinari Kato, Young Hong, Alex S Huang_ (2020) Functional, Structural, and Molecular Identification of Lymphatic Outflow From Subconjunctival Blebs Experimental eye Research. 196 108049- DOI:10.1016/j.exer.2020.108049

Yukinari Kato, Yoshikazu Furusawa, Masato Sano, Junko Takei, Takuro Nakamura, Miyuki Yanaka, Saki Okamoto, Saori Handa, Yu Komatsu, Teizo Asano, Yusuke Sayama, and Mika K. Kaneko (2020) Development of an Anti-Sheep Podoplanin Monoclonal Antibody PMab-256 for Immunohistochemical Analysis of Lymphatic Endothelial Cells Monoclonal Antibodies in Immunodiagnosis and Immunotherapy . DOI:10.1089/mab.2020.0005

Atsunori Oshima (2020) Structural insights into gap junction channels boosted by cryo-EM Current Opinion in Structural Biology. 63 42-48 DOI:10.1016/j.sbi.2020.03.008

Hiroshi Manya , Naoyuki Kuwabara , Ryuichi Kato , Tamao Endo (2020) FAM3B/PANDER-Like Carbohydrate-Binding Domain in a Glycosyltransferase, POMGNT1 Methods in molecular biology. 2132 609-619 DOI:10.1007/978-1-0716-0430-4_52

Shogo Miyoshi, Soh Tokunaga, Tatsuhiko Ozawa, Hiroyuki Takeda, Mitsuo Aono, Takanori Miyoshi, Hiroyuki Kishi,Atsushi Muraguchi, Shin-ichi Shimizu, Akira Nozawa , Tatsuya Sawasaki (2020) Production of a rabbit monoclonal antibody for highly sensitive detection of citrus mosaic virus and related viruses Pathology International. 15 :4, DOI:10.1371/journal.pone.0229196

Satoshi Shibata, Mikio Shoji, Kodai Okada, Hideyuki Matsunami, Melissa M. Matthews, Katsumi Imada, Koji Nakayama& Matthias Wolf_ (2020) Structure of polymerized type V pilin reveals assembly mechanism involving protease-mediated strand exchange Nature Microbiology. 5 830-837 DOI:10.1038/s41564-020-0705-1

Shinji Yamada, Mika K. Kaneko, Yusuke Sayama, Teizo Asano, Masato Sano, Miyuki Yanaka, Takuro Nakamura, Saki Okamoto, Saori Handa, Yu Komatsu, Yoshimi Nakamura, Yoshikazu Furusawa, Junko Takei, and Yukinari Kato (2020) Development of Novel Mouse Monoclonal Antibodies Against Human CD19 Monoclonal Antibodies in Immunodiagnosis and Immunotherapy . DOI:10.1089/mab.2020.0003

Chenjiang Liu, Yoshihiro Kobashigawa, Soichiro Yamauchi, Natsuki Fukuda, Takashi Sato, Takeshi Masuda, Sumio Ohtsuki, Hiroshi Morioka (2020) Convenient Method of Producing Cyclic Single-Chain Fv Antibodies by Split-Intein-Mediated Protein Ligation and Chaperone Co-Expression The Journal of Biochemistry. DOI:10.1093/jb/mvaa042

Yusuke Sayama, Masato Sano, Teizo Asano, Yoshikazu Furusawa, Junko Takei, Takuro Nakamura, Miyuki Yanaka, Saki Okamoto, Saori Handa, Yu Komatsu, Yoshimi Nakamura,Mikiko Yanagawa, Mika K. Kaneko, and Yukinari Kato (2020) Epitope Mapping of PMab-241, a Lymphatic Endothelial Cell-Specific Anti-Bear Podoplanin Monoclonal Antibody Monoclonal Antibodies in Immunodiagnosis and Immunotherapy . DOI:10.1089/mab.2020.0004

Hiroki Tanaka, Shoko Sato,Masako Koyama, Tomoya Kujirai and Hitoshi Kurumizaka (2020) Biochemical and structural analyses of the nucleosome containing human histone H2A.J The Journal of Biochemistry. 167 :4, 419-427 DOI:10.1093/jb/mvz109

Teizo Asano, Mika K Kaneko, Yukinari Kato (2020) RIEDL tag: A novel pentapeptide tagging system for transmembrane protein purification Biochemistry and Biophysics Reports. 23 DOI:10.1016/j.bbrep.2020.100780

Manuel E. Otero-Ramirez, Kyoko Matoba, Emiko Mihara, Toby Passioura, Junichi Takagi, Hiroaki Suga (2020) Macrocyclic peptides that inhibit Wnt signalling via interaction with Wnt3a RSC Chemical Biology . DOI:10.1039/D0CB00016G

Masataka Umitsu, Katsuya Sakai, Keiko Tamura-Kawakami, Kunio Matsumoto, Junichi Takagi (2020) The constitutive high-affinity Met-binding site in the kringle domain is dispensable for the signalling activity of hepatocyte growth factor Journal of Biochemistry. DOI:10.1093/jb/mvaa006

Kazumi Saikusa, Daiki Kato, Aritaka Nagadoi, Hitoshi Kurumizaka, Satoko Akashi (2020) Native Mass Spectrometry of Protein and DNA Complexes Prepared in Nonvolatile Buffers. Journal of the American Society for Mass Spectrometry. 31 711-718 DOI:10.1021/jasms.9b00145.

TomoyaKujirai, HitoshiKurumizaka (2020) Transcription through the nucleosome Current Opinion in Structural Biology . 61 42-49 DOI:10.1016/j.sbi.2019.10.007.

Risa Fujita, Tatsuro Yamamoto, Yasuhiro Arimura, Saori Fujiwara, Hiroaki Tachiwana, Yuichi Ichikawa, Yuka Sakata, Liying Yang, Reo Maruyama, Michiaki Hamada, Mitsuyoshi Nakao, Noriko Saitoh, Hitoshi Kurumizaka (2020) Nucleosome destabilization by nuclear non-coding RNAs Communications Biology. 3 60- DOI:10.1038/s42003-020-0784-9

Yoshimasa Takizawa,_Cheng-Han Ho,_Hiroaki Tachiwana,_Hideyuki Matsunami,_Wataru Kobayashi,_Midori Suzuki,_Yasuhiro Arimura,_Tetsuya Hori,_Tatsuo Fukagawa,_Melanie D Ohi,_Matthias Wolf,_Hitoshi Kurumizaka (2020) Cryo-EM Structures of Centromeric Tri-nucleosomes Containing a Central CENP-A Nucleosome Structure. 28 :1, 44-53 DOI:10.1016/j.str.2019.10.016

Assen Marintchev, Takuhiro Ito (2020) eIF2B and the Integrated Stress Response: A Structural and Mechanistic View Biochemistry. 59 :13, 1299-1308 DOI:10.1021/acs.biochem.0c00132

Xi Jiang, Ashutosh Kumar, Yasutaka Motomura, Tian Liu, Yong Zhou, Kazuyo Moro, Kam Y. J. Zhang, Qing Yang (2020) A series of compounds bearing a dipyrido-pyrimidine scaffold acting as novel human and insect pest chitinases inhibitors Journal of Medicinal Chemistry. 63 :3, 987-1001 DOI:10.1021/acs.jmedchem.9b01154

Eiko Seki, Tatsuo Yanagisawa, Mitsuo Kuratani, Kensaku Sakamoto, Shigeyuki Yokoyama (2020) Fully Productive Cell-Free Genetic Code Expansion by Structure-Based Engineering of Methanomethylophilus alvus Pyrrolysyl-tRNA Synthetase ACS Synthetic Biology. 9 :4, 718-732 DOI:10.1021/acssynbio.9b00288

Satoshi Yamanaka, Yusuke Sato, Daisuke Oikawa, Eiji Goto, Shuya Fukai, Fuminori Tokunaga, Hirotaka Takahashi, Tatsuya Sawasaki (2020) Subquinocin, a small molecule inhibitor of CYLD and USP-family deubiquitinating enzymes, promotes NF-κB signaling Biochemical and Biophysical Research Communications. 524 :1, 1-7 DOI:10.1016/j.bbrc.2019.12.049

Toshiko Yamazawa, Haruo Ogawa, Takashi Murayama, Maki Yamaguchi, Hideto Oyamada, Junji Suzuki, Nagomi Kurebayashi, Kazunori Kanemaru, Katsuji Oguchi, Takashi Sakurai, Masamitsu Iino (2020) Insights into channel modulation mechanism of RYR1 mutants using Ca2+ imaging and molecular dynamics Journal of General Physiology. 152 e201812235- DOI:10.1085/jgp.201812235

Haruo Ogawa, Nagomi Kurebayashi, Toshiko Yamazawa & Takashi Murayama (2020) Regulatory mechanisms of ryanodine receptor/Ca2+ release channel revealed by recent advancements in structural studies Journal of Muscle Research and Cell Motility_. 375 DOI:10.1007/s10974-020-09575-6

Simon Miller, You Lee Son, Yoshiki Aikawa, Eri Makino, Yoshiko Nagai, Ashutosh Srivastava, Tsuyoshi Oshima, Akiko Sugiyama, Aya Hara, Kazuhiro Abe, Kunio Hirata, Shinya Oishi, Shinya Hagihara, Ayato Sato, Florence Tama, Kenichiro Itami, Steve A. Kay, Megumi Hatori & Tsuyoshi Hirota (2020) Isoform-selective regulation of mammalian cryptochromes Nature Chemical Biology. DOI:10.1038/s41589-020-0505-1

Batuujin Burendei, Ruriko Shinozaki, Masakatsu Watanabe, Tohru Terada, Kazutoshi Tani, Yoshinori Fujiyoshi, Atsunori Oshima (2020) Cryo-EM structures of undocked innexin-6 hemichannels in phospholipids Science Advances. 6 :7, eaax3157- DOI:10.1126/sciadv.aax3157

Kotaro Koiwai, Kazue Inaba, Kana Morohashi, Sora Enya, Reina Arai, Hirotatsu Kojima, Takayoshi Okabe, Yuuta Fujikawa, Hideshi Inoue, Ryunosuke Yoshino, Takatsugu Hirokawa, Koichiro Kato, Kaori Fukuzawa, Yuko Shimada-Niwa, Akira Nakamura, Fumiaki Yumoto, Toshiya Senda and Ryusuke Niwa (2020) An integrated approach unravels a crucial structural property required for the function of the insect steroidogenic Halloween protein Noppera-bo Journal of Biological Chemistry. DOI:10.1074/jbc.RA119.011463

Satoshi Yasuda, Tomoki Akiyama, Sayaka Nemoto, Tomohiko Hayashi, Tetsuya Ueta, Keiichi Kojima, Takashi Tsukamoto, Satoru Nagatoishi, Kouhei Tsumoto, Yuki Sudo, *Masahiro Kinoshita and *Takeshi Murata (2020) Methodology for Further Thermostabilization of an Intrinsically Thermostable Membrane Protein Using Amino Acid Mutations with Its Original Function Being Retained Journal of Chemical Information and Modeling. 60 1709-1716 DOI:10.1021/acs.jcim.0c00063

Satoshi Yasuda, Kazuki Kazama, Tomoki Akiyama, *Masahiro Kinoshita and *Takeshi Murata (2020) Elucidation of cosolvent effects thermostabilizing water-soluble and membrane proteins Journal of Molecular Liquids. 301 112403-112411 DOI:10.1016/j.molliq.2019.112403

Tomohiko Hayashi, Satoshi Yasuda, Kano Suzuki, Tomoki Akiyama, Kanae Kanehara, Keiichi Kojima, Mikio Tanabe, Ryuichi Kato, Toshiya Senda, Yuki Sudo, Takeshi Murata, Masahiro Kinoshita (2020) How Does a Microbial Rhodopsin RxR Realize Its Exceptionally High Thermostability with the Proton-Pumping Function Being Retained? The Journal of Physical Chemistry B. 124 :6, 990-1000 DOI:10.1021/acs.jpcb.9b10700

Naoyuki Kuwabara, Rieko Imae, Hiroshi Manya, Tomohiro Tanaka, Mamoru Mizuno, Hiroki Tsumoto, Motoi Kanagawa, Kazuhiro Kobayashi, Tatsushi Toda, Toshiya Senda, Tamao Endo, Ryuichi Kato (2020) Crystal structures of fukutin-related protein (FKRP), a ribitol-phosphate transferase related to muscular dystrophy Nature Communications. 11 303- DOI:10.1038/s41467-019-14220-z

Xiaomei Sun_ Yuxin Ye_ Naofumi Sakurai_ Koji Kato_ Keizo Yuasa_ Akihiko Tsuji_ Min Yao (2020) Crystallographic analysis of Eisenia hydrolysis‐enhancing protein using a long wavelength for native‐SAD phasing Acta Crystallographica Section F. F76 20-24 DOI:10.1107/S2053230X19016716

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Kunihiko Morihiro, Osamu Hasegawa, Yuuya Kasahara, Shohei Mori, Tatsuro Kasai, Masayasu Kuwahara, Satoshi Obika (2020) Azobenzene-modified DNA aptamers evolved by capillary electrophoresis (CE)-SELEX method Bioorganic & Medicinal Chemistry Letters. DOI:10.1016/j.bmcl.2020.127607

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Yohei Matsumoto , Jun Sawamura , Yumi Murata , Takashi Nishikata , Ryo Yazaki , Takashi Ohshima (2020) Amino Acid Schiff Base Bearing Benzophenone Imine As a Platform for Highly Congested Unnatural α-Amino Acid Synthesis Journal of the American Chemical Society. 142 :18, 8498-8505 DOI:10.1021/jacs.0c02707

Shohei Ohno, and Mitsuhiro Arisawa (2020) Cyclizations of benzo-fused substrates involving two multiple bonds, including heteroatom-substituted unsaturated bond The Journal of Organic Chemistry. DOI:10.1021/acs.joc.0c00452

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YujiSumii, NaoyukiKotoku, ChisuHan, KentaroKamiya, AndiSetiawan, CatherineVilch_ze, William R.JacobsJr., MasayoshiArai (2020) 3-(Phenethylamino)demethyl(oxy)aaptamine as an anti-dormant mycobacterial substance: Isolation, evaluation and total synthesis Tetrahedron Letters. 61 :22, DOI:10.1016/j.tetlet.2020.151924

Hibiki Komine, Shohei Mori, Kunihiko Morihiro, Kenta Ishida, Takumi Okuda, Yuuya Kasahara, Hiroshi Aoyama, Takao Yamaguchi and Satoshi Obika (2020) Synthesis and Evaluation of Artificial Nucleic Acid Bearing an Oxanorbornane Scaffold Molecules. 25 :7, DOI:10.3390/molecules25071732

Mami Sato, Hirokazu Fuchida, Naoya Shindo, Keiko Kuwata, Keisuke Tokunaga, Guo Xiao-Lin, Ryo Inamori, Keitaro Hosokawa, Kosuke Watari, Tomohiro Shibata, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo, Mayumi Ono, and Akio Ojida (2020) Selective Covalent Targeting of Mutated EGFR(T790M) with Chlorofluoroacetamide-Pyrimidines ACS Medicinal Chemistry Letters. DOI:10.1021/acsmedchemlett.9b00574

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Nana Nakada‐Motokawa, Taiga Miyazaki, Satoshi Mizuta, Yoshimasa Tanaka, Tatsuro Hirayama, Takahiro Takazono, Tomomi Saijo, Kazuko Yamamoto, Yoshifumi Imamura, Koichi Izumikawa, Katsunori Yanagihara, Koichi Makimura, Kohsuke Takeda, Shigeru Kohno, Hiroshi Mukae (2020) Design and Synthesis of a Class of Compounds That Inhibit the Growth of Fungi Which Cause Invasive Infections Chemistry Select. 5 :3, 1140-1145 DOI:10.1002/slct.201904380

Kosuke Ohsawa, Hongbin Zhao, Takuya Tokunaga, Carys Thomas, A. Ganesan, Yuichi Masuda, Takayuki Doi (2020) Stereoselective Synthesis of Protected l-allo-Enduracididine and l-Enduracididine via Asymmetric Nitroaldol Reaction Synthesis. 52 :6, 942-948 DOI:10.1055/s-0039-1691522

Haruhisa Kikuchi, Ikuko Ito, Katsunori Takahashi, Hirotaka Ishigaki, Kyoichi Iizumi, Yuzuru Kubohara, Yoshiteru Oshima (2020) Isolation, Synthesis, and Biological Activity of Chlorinated Alkylresorcinols from Dictyostelium Cellular Slime Molds. Molecular and Cellular Biology. 80 :10, 2716-2722 DOI:10.1021/acs.jnatprod.7b00456

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Alif Meem Nurani, Yasuko Ozawa, Tomoyuki Furuya, Yuki Sakamoto, Kazuo Ebine, Sachihiro Matsunaga, Takashi Ueda, Hiroo Fukuda, Yuki Kondo (2020) Deep Imaging Analysis in VISUAL Reveals the Role of YABBY Genes in Vascular Stem Cell Fate Determination Plant and Cell Physiology. 61 :2, 255-264 DOI:10.1093/pcp/pcaa002

Ryohei Yonesaki, Ibuki Kusagawa, Hiroyuki Morimoto, Tamio Hayashi, Takashi Ohshima (2020) Rhodium(I)/Chiral Diene‐Catalyzed Enantioselective Addition of Boronic Acids to N‐Unsubstituted Isatin‐Derived Ketimines Chemistry An Asian Journal. 15 :4, 499-502 DOI:10.1002/asia.201901745

Ryoko Igarashi, Shun-ichi Yamashita, Tomohiro Yamashita, Keiichi Inoue, Tomoyuki Fukuda, Takeo Fukuchi, Tomotake Kanki (2020) Gemcitabine induces Parkin-independent mitophagy through mitochondrial-resident E3 ligase MUL1-mediated stabilization of PINK1 Scientific Reports. 10 1465- DOI:10.1038/s41598-020-58315-w

Yuta Kondo, Tetsuya Kadota, Yoshinobu Hirazawa, Kazuhiro Morisaki, Hiroyuki Morimoto, Takashi Ohshima (2020) Scandium(III) Triflate Catalyzed Direct Synthesis of N-Unprotected Ketimines Organic Letters. 22 :1, 120-125 DOI:10.1021/acs.orglett.9b04038

Yu Hidaka, Noriaki Kiya, Makoto Yoritate, Kazuteru Usui, Go Hirai (2020) Synthesis of CH2-linked α-galactosylceramide and its glucose analogues through glycosyl radical-mediated direct C-glycosylation Chemical Communications. DOI:10.1039/D0CC00785D

Shohei Uchinomiya, Naoya Matsunaga, Koichiro Kamoda, Ryosuke Kawagoe, Akito Tsuruta, Shigehiro Ohdo, Akio Ojida (2020) Fluorescence detection of metabolic activity of the fatty acid beta oxidation pathway in living cells Chemical Communications. 56 :20, 3023-3026 DOI:10.1039/C9CC09993J

Tsukushi Tanaka, Ryo Yazaki, Takashi Ohshima (2020) Chemoselective Catalytic α-Oxidation of Carboxylic Acids: Iron/Alkali Metal Cooperative Redox Active Catalysis Journal of the American Chemical Society . 142 :9, 4517-4524 DOI:10.1021/jacs.0c00727

Keisuke Koga, Ryo Yamagata, Keita Kohno, Takuya Yamane, Miho Shiratori-Hayashi,Yuta Kohro, Hidetoshi Tozaki-Saitoh, Makoto Tsuda, Makoto Tsuda (2020) Sensitization of spinal itch transmission neurons in a mouse model of chronic itch requires an astrocytic factor Journal of Allergy and Clinical Immunology. 145 :1, 183-191 DOI:10.1016/j.jaci.2019.09.034

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Kengo Hirao, Sophie Andrews, Kimiko Kuroki, Hiroki Kusaka, Takashi Tadokoro, Shunsuke Kita, Toyoyuki Ose, Sarah L. Rowland-Jones, and Katsumi Maenaka (2020) Structure of HIV-2 Nef Reveals Features Distinct from HIV-1 Involved in Immune Regulation iScience.. 23 :1, DOI:10.1016/j.isci.2019.100758

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Takashi Tadokoro, Cassandra M. Modahl, Katsumi Maenaka, and Narumi Aoki-Shioi (2020) Cysteine-Rich Secretory Proteins (CRISPs) From Venomous Snakes: An Overview of the Functional Diversity in A Large and Underappreciated Superfamily Toxins. 12 :3, e175- DOI:10.3390/toxins12030175

Hiroki Kusaka, Shunsuke Kita, Takashi Tadokoro, Kouki Yoshida, Yoshiyuki Kasai, Harumi Niiyama, Yukari Fujimoto, Shinya Hanashima, Michio Murata, Shigeru Sugiyama, Toyoyuki Ose, Kimiko Kuroki, Katsumi Maenaka (2020) Efficient preparation of human and mouse CD1d proteins using silkworm baculovirus expression system Protein Expression and Purification. 105631- DOI:10.1016/j.pep.2020.105631

Hiroaki Oyama, Hiroki Koga, Takashi Tadokoro, Katsumi Maenaka, Akira Shiota, Masami Yokoyama, Masanori Noda, Tetsuo Torisu, Susumu Uchiyama (2020) Relation of Colloidal and Conformational Stabilities to Aggregate Formation in a Monoclonal Antibody Journal of Pharmaceutical Sciences. 109 :1, 308-315 DOI:10.1016/j.xphs.2019.10.038

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Yoshihiko Yamamoto, Motoji Sakai, Yuki Ishida, Takeshi Yasui (2020) Synthesis of 1_(Difluoromethyl)alk-1-enes via Palladium-Catalyzed SN2′-Type Substitution Reaction of Difluoromethylated Allylic Phosphates with 1,3-Dicarbonyl Compounds and Imides The Journal of Organic chemistry. DOI:10.1021/acs.joc.0c02538

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Takumi Yasuno, Tomoyuki Ohe, Hiroki Kataoka, Kosho Hashimoto, Yumiko Ishikawa, Keigo Furukawa, Yasuhiro Tateishi, Toi Kobayashi, Kyoko Takahashi, Shigeo Nakamura, Tadahiko Mashino (2020) Fullerene derivatives as dual inhibitors of HIV-1 reverse transcriptase and protease Bioorganic & Medicinal Chemistry Letters. DOI:10.1016/j.bmcl.2020.127675

Yoshitake Nishiyama, Kei Akiyama, Yuki Sakata, Takamitsu Hosoya, and Suguru Yoshida (2020) Facile Synthesis of Tetraarylpyrazines by Sequential Cross-coupling Approach Chemistry Letters. DOI:10.1246/cl.200715

Norikazu Terashima, Yuki Sakata, Tomohiro Meguro, Takamitsu Hosoya, and Suguru Yoshida (2020) Triazole formation of phosphinyl alkynes with azides through transient protection of phosphine by copper Chemical communications. DOI:10.1039/D0CC06551J

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Juri Sakata, Kazunari Akita, Manabu Sato, Masashi Shimomura, and Hidetoshi Tokuyama (2020) Cyclic Sulfamidite as Simultaneous Protecting Group for Amino Alcohols: Development of a Mild Deprotection Protocol Using Thiophenol Chemical and Pharmaceutical Bulletin. 68 :10, 996-1000 DOI:10.1248/cpb.c20-00531

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Tsubasa Matsuzawa, Takamitsu Hosoya and Suguru Yoshida (2020) One-step synthesis of benzo[b]thiophenes by aryne reaction with alkynyl sulfides Chemical Science. DOI:10.1039/d0sc04450d

Naoaki Makio , Yuki Sakata , Tomoko Kuribara , Keisuke Adachi , Yasutomo Hatakeyama , Tomohiro Meguro , Kazunobu Igawa , Katsuhiko Tomooka , Takamitsu Hosoya and Suguru Yoshida (2020) (Hexafluoroacetylacetonato)copper(I)_cycloalkyne complexes as protected cycloalkynes Chemical communications. DOI:10.1039/D0CC05182A.

Yuto Sumida, Ryu Harada, Tomoe Sumida, Kohei Johmoto, Hidehiro Uekusa, Takamitsu Hosoya (2020) Synthesis of Dibenzofurans by Cu-Catalyzed Deborylative Ring Contraction of Dibenzoxaborin Organic Letters. DOI:10.1021/acs.orglett.0c02584

Miyuki Yamaguchi, Ryoya Hagiwara, Kanami Gayama, Kohei Suzuki, Yusuke Sato, Hideyuki Konishi, and Kei Manabe (2020) Direct C3-Selective Arylation of N-Unsubstituted Indoles with Aryl Chlorides, Triflates, and Nonaflates Using a Palladium_Dihydroxyterphenylphosphine Catalyst The Journal of Organic chemistry. DOI:10.1021/acs.joc.0c01494

Tsukasa Sawato ,Mieko Arisawa , and Masahiko Yamaguchi (2020) Reversible Formation of Self-assembly Gels Containing Giant Vesicles in Trifluoromethylbenzene Using Oxymethylenehelicene Oligomers with Terminal C16 Alkyl Groups Bulletin of the Chemical Society of Japan. DOI:10.1246/bcsj.20200164

Noriyuki Natsume, Kaori Ozaki, Daisuke Nakajima, Satoshi Yokoshima, Toshiaki Teruya (2020) Structure－Activity Relationship Study of Majusculamides A and B and Their Analogues on Osteogenic Activity Journal of Natural products. DOI:10.1021/acs.jnatprod.0c00441

Satoshi Yokoshima (2020) Synthesis of Polycyclic Natural Products through Skeletal Rearrangement Synlett. 31 DOI:10.1055/s-0040-1707904

Satoshi Inouye, Mitsuhiro Nakamura, Jumpei Taguchi, Takamitsu Hosoya (2020) Identification of a novel oxidation product from yellow fluorophore in the complex of apoPholasin and dehydrocoelenterazine Bioorganic & Medicinal Chemistry Letters. 30 :19, DOI:10.1016/j.bmcl.2020.127435

Keisuke Adachi,Tomohiro Meguro, Yuki Sakata, Kazunobu Igawa, Katsuhiko Tomooka, Takamitsu Hosoya and Suguru Yoshida (2020) Selective strain-promoted azide_alkyne cycloadditions through transient protection of bicyclo[6.1.0]nonynes with silver or gold Chemical Communications. DOI:10.1039/D0CC04606J

Rina Maeda, Shinji Ito, Kaori Hashiya, Toshikazu Bando, Hiroshi Sugiyama (2020) DNA alkylation of the RUNX-binding sequence by CBI-PI polyamide comjugates Chemistry A European Journal. DOI:10.1002/chem.202002166

ShinyaFujii, ErikoKikuchi, YukoWatanabe, HonokaSuzuyama, MariIshigami-Yuasa, TakayasuMori, KiyoshiIsobe, ShinichiUchida, HiroyukiKagechika (2020) Structural development of N-(4-phenoxyphenyl)benzamide derivatives as novel SPAK inhibitors blocking WNK kinase signaling Bioorganic & Medicinal Chemistry Letters. 30 :17, DOI:10.1016/j.bmcl.2020.127408

Mieko Arisawa (2020) Transition-Metal-Catalyzed Synthesis of Organophosphorus Compounds Involving P_P Bond Cleavage Synthesis. DOI:10.1055/s-0040-1707890

Yumi Yamashita, Louna Poignant, Juri Sakata, and Hidetoshi Tokuyama (2020) Divergent Total Syntheses of Isobatzellines A/B and Batzelline A Organic Letters. DOI:10.1021/acs.orglett.0c01894

Hiromichi Egami, Ryo Hotta, Minami Otsubo, Taiki Rouno, Tomoki Niwa, Kenji Yamashita, and Yoshitaka Hamashima (2020) Asymmetric Dearomatizing Fluoroamidation of Indole Derivatives with Dianionic Phase-Transfer Catalyst Organic Letters. DOI:10.1021/acs.orglett.0c02026

Kenji Watanabe, Nodoka Terao, Isao Kii, Reiko Nakagawa, Takashi Niwa , Takamitsu Hosoya (2020) Indolizines Enabling Rapid Uncaging of Alcohols and Carboxylic Acids by Red Light-Induced Photooxidation Organic Letters. DOI:10.1021/acs.orglett.0c01799

Kanako Nozawa-Kumada, Yuki Iwakawa, So Onuma, Masanori Shigeno and Yoshinori Kondo (2020) NaH-mediated direct C_H arylation in the presence of 1,10- phenanthroline Chemical Communications. DOI:10.1039/D0CC00730G

Yuya Tamura, Yasunori Minami, Yoshitake Nishiyama, Yuki Sakata, Fumika Karaki, Takamitsu Hosoya, Suguru Yoshida_ (2020) Synthesis of Multisubstituted Cycloalkenes Through Carbomagnesiation of Strained Cycloalkynes Chemical communications. DOI:10.1039/d0cc02788j

Takuya Yoshida, Hiroya Oki, Michihiro Doi, Syohei Fukuda, Tomohiro Yuzuriha, Ryotaro Tabata, Kenji Ishimoto, Kazuki Kawahara, Tadayasu Ohkubo, Hiroyuki Miyachi, Takefumi Doi & Keisuke Tachibana (2020) Structural Basis for PPARα Activation by 1H-pyrazolo-[3,5-b]pyridine Derivatives Scientific Reports. 10 :1, DOI:10.1038/s41598-020-64527-x

Kyosuke Ueda and Satoshi Yokoshima (2020) Synthetic Studies on Densanins: Stereoselective Construction of a Pyrrolidine Ring Containing a Quaternary Carbon Heterocycles. 103 DOI:10.3987/COM - 20 - S(K)4

Akihiro Kobayashi, Tsubasa Matsuzawa, Takamitsu Hosoya, and Suguru Yoshida (2020) One-pot Synthesis of Allyl Sulfides from Sulfinate Esters and Allylsilan through Reduction of Alkoxysulfonium Intermediates Chemistry Letters. DOI:10.1246/cl.200285

Haruka Murakami, Tomohiro Asakawa, Yoshihiro Muramatsu, Ryo Ishikawa, Aiki Hiza, Yuta Tsukaguchi, Yohei Tokumaru, Masahiro Egi, Makoto Inai, Hitoshi Ouchi, Fumihiko Yoshimura, Tohru Taniguchi, Yoshinobu Ishikawa, Mitsuru Kondo, and Toshiyuki Kan (2020) Total Synthesis of Sophoraflavanone H and Con firmation of Its Absolute Configuration Organic Letters. 22 :10, 3820-3824 DOI:10.1021/acs.orglett.0c01063

Yusuke Miura , Hitoshi Ouchi , Makoto Inai , Taisei Osawa , Fumihiko Yoshimura , Junichiro Kanazawa , Masanobu Uchiyama, Mitsuru Kondo , Toshiyuki Kan (2020) Synthetic Studies on Pactamycin: A Synthesis of Johnson's Intermediate Organic Letters. 22 :9, 3515-3518 DOI:10.1021/acs.orglett.0c00959

Yoshitake Nishiyama, Takamitsu Hosoya and Suguru Yoshida (2020) Synthesis of benzyl sulfides via substitution reaction at the sulfur of phosphinic acid thioesters Chemical Communications. 56 :43, 5771-5774 DOI:10.1039/d0cc02039g

Kotaro Mutsuura ,Yuki Sakata ,Keisuke Uchida ,Takamitsu Hosoya , and Suguru Yoshida (2020) Synthesis of Thioxanthones through Formal C_H Thiolation of Benzoic Acid Esters and Acid-mediated Direct Cyclization Chemistry Letters. DOI:10.1246/cl.200190

Takayoshi Nakaoka, Yuta Uetake, Ken-ichi Kaneko, Takashi Niwa, Hidenori Ochiai, Satsuki Irie, Yoshie Suezaki, Natsumi Otsuka, Emi Hayashinaka, Yasuhiro Wada, Yilong Cui, Kazuya Maeda, Hiroyuki Kusuhara, Yuichi Sugiyama, Takamitsu Hosoya, and Yasuyoshi Watanabe (2020) Practical Synthesis of [18F]Pitavastatin and Evaluation of Hepatobiliary Transport Activity in Rats by Positron Emission Tomography Molecular Pharmaceutics. DOI:10.1021/acs.molpharmaceut.9b01284

Michitaka Kurimoto, Daisuke Nakajima, Yoshitake Nishiyama, Satoshi Yokoshima (2020) Semipinacol Rearrangement Induced by Cleavage of Dibromocyclopropane European journal of Organic Chemistry. DOI:10.1002/ejoc.202000355

Mieko Arisawa,___ Kohei Fukumoto_ and_ Masahiko Yamaguchi_ (2020) Rhodium-catalyzed phosphorylation reaction of water-soluble disulfides using hypodiphosphoric acid tetraalkyl esters in water RSC Advances. 10 13820-13823 DOI:10.1039/d0ra02377a

KoheiTsuji, Kofi Baffour-AwuahOwusu,TakuyaKobayakawa,RongyiWang,MasayukiFujino, MoemiKaneko, NaokiYamamoto, TsutomuMurakami,HirokazuTamamura (2020) Exploratory studies on CA-15L, an anti-HIV active HIV-1 capsid fragment Bioorganic & Medicinal Chemistry. 28 :11, DOI:10.1016/j.bmc.2020.115488

Miyuki Yamaguchi, Kota Ogihara, Hideyuki Konishi, Kei Manabe (2020) Synthesis of 2,3-disubstituted indoles from alkynylanilines and 2-chlorophenols using palladium_dihydroxyterphenylphosphine catalys Tetrahedron Letters. 61 :21, DOI:10.1016/j.tetlet.2020.151896

Satoshi Inouye, Yuiko Miura-Sahara, Rie Iimori, Yuki Sakata, Yuki Hazama, Suguru Yoshida, Mitsuhiro Nakamura, Takamitsu Hosoya (2020) A novel yellow fluorescent protein of recombinant apoPholasin with dehydrocoelenterazine Biochemical and Biophysical Research Communications. 526 :2, 404-409 DOI:10.1016/j.bbrc.2020.03.085

Youngchan Kim,_ Kazuya Kanemoto,_ Ken Shimomori,_ Takamitsu Hosoya,_ Suguru Yoshida (2020) Functionalization of a Single C_F Bond of Trifluoromethylarenes Assisted by an ortho-Silyl Group Using a Trityl-Based All-in-One Reagent with Ytterbium Triflate Catalyst Chemistry _ A European Journal: List of Issues. DOI:10.1002/chem.202001315

SatoshiInouye, YuikoMiura-Sahara, RieIimoriYukiSakata, YukiHazama, SuguruYoshida, MitsuhiroNakamura, TakamitsuHosoya (2020) A novel yellow fluorescent protein of recombinant apoPholasin with dehydrocoelenterazine Biochemical and Biophysical Research Communications. 526 :2, 404-409 DOI:10.1016/j.bbrc.2020.03.085

Tsuneyuki Kobayashi, Takamitsu Hosoya, Suguru Yoshida (2020) Consecutive Aryne Generation Strategy for the Synthesis of 1,3-Diarylpyrazoles The Journal of Organic Chemistry. 85 :6, 4448-4462 DOI:10.1021/acs.joc.0c00172

Kazuya Kanemoto, Yuki Sakata, Takamitsu Hosoya, Suguru Yoshida (2020) Synthesis of Phenoxathiins and Phenothiazines by Aryne Reactions with Thiosulfonates Chemistry Letters. DOI:10.1246/cl.200132

Tomohiro Meguro, Yuki Sakata, Takamoto Morita, Takamitsu Hosoya, Suguru Yoshida (2020) Facile assembly of three cycloalkyne-modules onto a platform compound bearing thiophene S,S-dioxide moiety and two azido groups Chemical Comunications. DOI:10.1039/D0CC01810D

Takashi Niwa, Takamitsu Hosoya (2020) Molecular Renovation Strategy for Expeditious Synthesis of Molecular Probes Bulletin of the Chemical Society of Japan. 93 :2, 230-248 DOI:10.1246/bcsj.20190310

Akihiro Shiogai, Tatsuya Toma, Satoshi Yokoshima (2020) Synthetic Studies on Bilobalide Synlett. 31 :3, 290-294 DOI:10.1055/s-0039-1691559

Yoshihiko Yamamoto, Jiyue Jiang, Takeshi Yasui (2020) Palladium‐Catalyzed [3+2] and [2+2+2] Annulations of 4‐Iodo‐2‐quinolones with Activated Alkynes through Selective C－H Activation Chemistry A European Journal. 26 :17, 3749-3757 DOI:10.1002/chem.201904558

Shoutaro Iwase, Yusuke Suzuki, Shinji Tanaka, Masato Kitamura (2020) CpRu/Br_nsted Acid-Catalyzed Enantioselective Dehydrative Cyclization of Pyrroles N-Tethered with Allylic Alcohols Organic Letters. 22 :5, 1929-1933 DOI:10.1021/acs.orglett.0c00290

Keigo Murakami, Tatsuya Toma, Tohru Fukuyama, Satoshi Yokoshima (2020) Total Synthesis of Tetrodotoxin Angewandte Chemie. DOI:10.1002/ange.201916611

Keisuke Tachibana, Masuo Kondoh (2020) A Method to Prepare Claudin-Modulating Recombinant Proteins Methods in Molecular Biology. 2109 251-260 DOI:10.1007/7651_2019_258

Mieko Arisawa, Ren Suzuki, Keiichiro Ohashi, Masahiko Yamaguchi (2020) Rhodium-catalyzed Synthesis of Heteroarylselenyl Esters from Diheteroaryl Diselenides and Acid Fluorides Asian Journal of Organic Chemistry. DOI:10.1002/ajoc.202000077

Mieko Arisawa, Katsuya Nakai, Tomoki Yamada, Ren Suzuki, Masahiko Yamaguchia (2020) Synthesis of cycloalkyl/steroidal heteroaryl sulfides using rhodium-catalyzed heteroaryl exchange reaction Heterocycles. 100 :1, 104-118 DOI:10.3987/COM-19-14147

Yuichi Onda, Kazuki Fukushi, Kosuke Ohsawa, Masahito Yoshida, Yuichi Masuda, Takayuki Doi (2020) Synthesis of a Biphenylalanine Analogue of Apratoxin A Displaying Substantially Enhanced Cytotoxicity Heterocycles. 101 :2, 679-691 DOI:10.3987/COM-19-S(F)35

Masashi Shimomura, Manabu Sato, Hiroki Azuma, Juri Sakata, Hidetoshi Tokuyama (2020) Total Synthesis of (－)-Lepadiformine A via Radical Translocation_Cyclization Reaction Organic Letters. DOI:10.1021/acs.orglett.0c00474

Yasuhiro Tateishi, Tomoyuki Ohe, Daisuke Yasuda, Kyoko Takahashi, Shigeo Nakamura, Yasuhiro Kazuki, Tadahiko Mashino_ (2020) Synthesis and evaluation of nevirapine analogs to study the metabolic activation of nevirapine Drug Metabolism and Pharmacokinetics. 35 :2, 238-243 DOI:10.1016/j.dmpk.2020.01.006

Daisuke Yasuda, Tomoyuki Ohe, Kyoko Takahashi, Riyo Imamura, Hirotatsu Kojima, Takayoshi Okabe, Yoshinobu Ichimura, Masaaki Komatsu, Masayuki Yamamoto, Tetsuo Nagano, Tadahiko Mashino (2020) Inhibitors of the protein_protein interaction between phosphorylated p62 and Keap1 attenuate chemoresistance in a human hepatocellular carcinoma cell line Free Radical Research. DOI:10.1080/10715762.2020.1732955

Wakako Kuribayashi, Motohiko Oshima, Naoki Itokawa, Shuhei Koide, Yaeko Nakajima-Takagi, Masayuki Yamashita, Satoshi Yamazaki, Bahityar Rahmutulla, Fumihito Miura, Takashi Ito, Atsushi Kaneda, Atsushi Iwama (2020) Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche Journal of Experimental medicine. 218 DOI:10.1084/jem.20192283

Yohei Inai, Takeshi Izawa, Mutsuki Mori, Machi Atarashi, Seiichirou Tsuchiya, Mitsuru Kuwamura, Jyoji Yamate (2020) Analyses of Hemorrhagic Diathesis in High-Iron Diet-Fed Rats Journal of Toxicologic Pathology. DOI:10.1293/tox.2020-0004

Yuhei Sangatsuda, Fumihito Miura, Hiromitsu Araki, Masahiro Mizoguchi, Nobuhiro Hata, Daisuke Kuga, Ryusuke Hatae, Yojiro Akagi, Takeo Amemiya, Yutaka Fujioka, Yasuhito Arai, Akihiko Yoshida, Tatsuhiro Shibata, Koji Yoshimoto, Koji Iihara & Takashi Ito (2020) Base_resolution methylomes of gliomas bearing histone H3.3 mutations reveal a G35 mutant_specific signature shared with bone tumors Scientific Reports. 10 DOI:10.1038/s41598-020-73116-x

Nahid Rahman, Mizuki Kuramochi, Takeshi Izawa, Mitsuru Kuwamura, Jyoji Yamate (2020) Characterization of Immature Myofibroblasts of Stellate Cell or Mesenchymal Cell Origin in D-Galactosamine-Induced Liver Injury in Rats Veterinary Pathology. DOI:10.1177/0300985820963097

Ryoji Ito, Ikumi Katano, Iyo Otsuka, Takeshi Takahashi, Hiroshi Suemizu, Mamoru Ito and Peter J. Simons (2020) Bovine β-lactoglobulin-induced passive systemic anaphylaxis model using humanized NOG hIL-2/hGM-CSF transgenic mice international immunology. :9, DOI:10.1093/intimm/dxaa067

Mutsuki Mori, Takeshi Izawa, Yohei Inai, Sho Fujiwara, Ryo Aikawa, Mitsuru Kuwamura and Jyoji Yamate (2020) Dietary Iron Overload Differentially Modulates Chemically-Induced Liver Injury in Rats nutrients. 12 DOI:10.3390/nu12092784

Yuhei Sangatsuda, Fumihito Miura, Hiromitsu Araki, Masahiro Mizoguchi, Nobuhiro Hata, Daisuke Kuga, Ryusuke Hatae, Yojiro Akagi, Takeo Amemiya, Yutaka Fujioka, Yasuhito Arai, Akihiko Yoshida, Tatsuhiro Shibata, Koji Yoshimoto, Koji Iihara, Takashi Ito (2020) Base_resolution methylomes of gliomas bearing histone H3.3 mutations reveal a G34 mutant_specific signature shared with bone tumors Scientific Reports. 10 DOI:10.1038/s41598-020-73116-x

Mutsuki Mori, Takeshi Izawa * , Yohei Inai, Sho Fujiwara, Ryo Aikawa, Mitsuru Kuwamura and Jyoji Yamate (2020) Dietary Iron Overload Di erentially Modulates Chemically-Induced Liver Injury in Rats nutrients. DOI:10.3390/nu12092784

Yumi Ohta, Kanako Kazuki, Satoshi Abe, Mitsuo Oshimura, Kaoru Kobayashi, Yasuhiro Kazuki (2020) Development of Caco-2 cells expressing four CYPs via a mammalian artificial chromosome BMC Biotechnology. 20 DOI:10.1186/s12896-020-00637-8

Noa HADA, Mizuki KURAMOCHI, Takeshi IZAWA, Mitsuru KUWAMURA, Jyoji YAMATE (2020) Effects of dexamethasone on hepatic macrophages in normal livers and thioacetamide-induced acute liver lesions in rats Journal of Toxicologic Pathology. DOI:10.1293/tox.2020-0016

Takako Ohyama, Hazuki Takahashi, Harshita Sharma, Toshio Yamazaki, Stefano Gustincich, Yoshitaka Ishii, Piero Carninci (2020) An NMR-based approach reveals the core structure of the functional domain of SINEUP lncRNAs Nucleic acids research. DOI:10.1093/nar/gkaa598

Shinya Tanaka, Wataru Ise, Takeshi Inoue, Ayako Ito, Chisato Ono, Yoshihito Shima, Shuhei Sakakibara, Manabu Nakayama, Kentaro Fujii, Ikuo Miura, Jafar Sharif, Haruhiko Koseki, Pandelakis A. Koni, Indu Raman, Quan-Zhen Li, Masato Kubo, Katsunori Fujiki, Ryuichiro Nakato, Katsuhiko Shirahige, Hiromitsu Araki, Fumihito Miura, Takashi Ito, Eiryo Kawakami, Yoshihiro Baba& Tomohiro Kurosaki_ (2020) Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity nature immunology. :1, 7083- DOI:10.1038/s41590-020-0700-y

Miki Yamazaki_ , Masahito Hosokawa_ , Koji Arikawa_ , Kiyofumi Takahashi_ , Chikako Sakanashi_ , Takuya Yoda_ , Hiroko Matsunaga_ , Haruko Takeyama (2020) Efective microtissue RNA extraction coupled with Smart-seq2 for reproducible and robust spatial transcriptome analysis Scientific Reports. 10 :5, 1088- DOI:10.1038/s41598-020-63495-6

Takuro Horii_ , Ryosuke Kobayashi_ , Mika Kimura_ , Sumiyo Morita_ , Izuho Hatada_ (2020) Calcium-Free and Cytochalasin B Treatment Inhibits Blastomere Fusion in 2-Cell Stage Embryos for the Generation of Floxed Mice via Sequential Electroporation cells. 9 :1, 7083- DOI:10.3390/cells9051088

Miki Yamazaki_ , Masahito Hosokawa_ , Koji Arikawa_ , Kiyofumi Takahashi , Chikako Sakanashi, Takuya Yoda , Hiroko Matsunaga , Haruko Takeyama (2020) Effective Microtissue RNA Extraction Coupled With Smart-seq2 for Reproducible and Robust Spatial Transcriptome Analysis Scientific Reports. 10 DOI:10.1038/s41598-020-63495-6

Takuro Horii, Sumiyo Morita, Shinjiro Hino, Mika Kimura, Yuko Hino, Hiroshi Kogo, Mitsuyoshi Nakao & Izuho Hatada_ (2020) Successful generation of epigenetic disease model mice by targeted demethylation of the epigenome Genome Biology. 21 DOI:10.1186/s13059-020-01991-8

Yamazaki M, Hosokawa M, Arikawa K, Takahashi K, Sakanashi C, Yoda T, Matsunaga H, Takeyama H (2020) Effective microtissue RNA extraction coupled with Smart-seq2 for reproducible and robust spatial transcriptome analysis Scientific Reports. 10 7083- DOI:10.1038/s41598-020-63495-6

Hayato Tsuyuzaki, Masahito Hosokawa, Koji Arikawa, Takuya Yoda, Naoyuki Okada, Haruko Takeyama, Masamitsu Sato (2020) Time-lapse single-cell transcriptomics reveals modulation of histone H3 for dormancy breaking in fission yeast Nature communications. 11 :2, 207-210 DOI:10.1038/s41467-020-15060-y

Shuichi Otani, Shohei Miki, Yuta Nakamura, Kenji Ishimoto, Yukio Ago, Shinsaku Nakagawa. (2020) Improved Bioavailability of b-Carotene by Amorphous Solid Dispersion Technology in Rats. Journal of Nutritional Science and Vitaminology . 66 :3, 509-523 DOI:10.3177/jnsv.66.207

Ai Hashimoto, Mohammad Rabiul Karim, Mizuki Kuramochi, Takeshi Izawa, Mitsuru Kuwamura, Jyoji Yamate (2020) Characterization of Macrophages and Myofibroblasts Appearing in Dibutyltin Dichloride_Induced Rat Pancreatic Fibrosis Toxicologic Pathology. 48 :4, 560-569 DOI:10.1177/0192623319893310

Hironobu Nishina, Chisa Katou-Ichikawa, Mizuki Kuramochi, Takeshi Izawa, Mitsuru Kuwamura, Jyoji Yamate (2020) Participation of Somatic Stem Cells, Recognized by a Unique A3 Antibody, in Mucosal Epithelial Regeneration in Dextran Sulfate Sodium (DSS)_Induced Rat Colonic Lesions Toxicologic Pathology. 48 :2, 238-243 DOI:10.1177/0192623320906817

YasuhiroTateishi, TomoyukiOhe, DaisukeYasuda, KyokoTakahashi, ShigeoNakamura, YasuhiroKazuki, TadahikoMashino (2020) Synthesis and evaluation of nevirapine analogs to study the metabolic activation of nevirapine. Drug Metab Pharmacokinet. 35 111914- DOI:10.1016/j.dmpk.2020.01.006

Takashi Moriwaki, Satoshi Abe, Mitsuo Oshimura, Yasuhiro Kazuki (2020) Transchromosomic technology for genomically humanized animals Experimental Cell Research. :1, 77-77 DOI:10.1016/j.yexcr.2020.111914

Takuro Horii, Sumiyo Morita, Shinjiro Hino, Mika Kimura, Yuko Hino, Hiroshi Kogo, Mitsuyoshi Nakao, Izuho Hatada (2020) Successful generation of epigenetic disease model mice by targeted demethylation of the epigenome Genome Biology. 21 :5, 1574- DOI:10.1186/s13059-020-01991-8

Sumiyo Morita, Takuro Horii, Mika Kimura, Izuho Hatada (2020) Synergistic Upregulation of Target Genes by TET1 and VP64 in the dCas9_SunTag Platform International Journal of Molecular Sciences. 21 :1, 58-70 DOI:10.3390/ijms21051574

Hiroko Izumi-Nakaseko, Masachika Fujiyoshi, Mihoko Hagiwara-Nagasawa, Ai Goto, Koki Chiba, Ryuichi Kambayashi, Atsuhiko T. Naito, Kentaro Ando, Yasunari Kanda, Itsuko Ishii, Atsushi Sugiyama (2020) Dasatinib can Impair Left Ventricular Mechanical Function But May Lack Proarrhythmic Effect: A Proposal of Non-clinical Guidance for Predicting Clinical Cardiovascular Adverse Events of Tyrosine Kinase Inhibitors Cardiovascular Toxicology. 20 :1, 100-109 DOI:10.1007/s12012-019-09538-5

Yuuri Yasuoka, Masahito Matsumoto, Ken Yagi, and Yasushi Okazaki (2020) Evolutionary History of GLIS Genes Illuminates their Roles in Cell Reprogramming and Ciliogenesis Molecular Biology and Evolution. 37 :4, DOI:10.1093/molbev/msz205

Tetsuhiro Ogawa, Kazutoshi Takahashi, Wataru Ishida, Toshihiro Aono, Makoto Hidaka, Tohru Terada, Haruhiko Masaki (2020) Substrate recognition mechanism of tRNAtargeting ribonuclease, colicin D, and an insight into tRNA cleavage-mediated translation impairment RNA Biology. DOI:doi:10.1080/15476286.2020.1838782

Magdalena _miech, Pawe_ Leszczy_ski, Hidetoshi Kono, Christopher Wardell, Hiroaki Taniguchi (2020) Emerging BRAF Mutations in Cancer Progression and Their Possible E ects on Transcriptional Networks Genes. 11 :11, DOI:doi:10.3390/genes11111342

Woong-Hee Shin 1 Keiko Kumazawa 2 Kenichiro Imai, Takatsugu Hirokawa, Daisuke Kihara (2020) Current Challenges and Opportunities in Designing Protein_Protein Interaction Targeted Drugs Advances and Applications in Bioinformatics and Chemistry. 13 11-25 DOI:doi:10.2147/AABC.S235542

Daiki Koge, Naoaki Ono, Ming Huang, Md Altaf-Ul-Amin, Shigehiko Kanaya (2020) Embedding of Molecular Structure Using Molecular Hypergraph Variational Autoencoder with Metric Learning molecular informatics. DOI:doi:10.1002/minf.202000203

Chiduru Watanabe, Yoshio Okiyama, Shigenori Tanaka, Kaori Fukuzawa, Teruki Honma (2020) Molecular Recognition of SARS-CoV-2 Spike Glycoprotein: Quantum Chemical Hot Spot and Epitope Analyses ChemRxiv. DOI:doi:10.26434/chemrxiv.13200176

Shingo Tojo, Zhikuan Zhang, Hiroyuki Matsui, Masahiro Tahara, Mitsunori Ikeguchi, Mami Kochi, Mami Kamada, Hideki Shigematsu, Akihisa Tsutsumi, Naruhiko Adachi, Takuma Shibata, Masaki Yamamoto, Masahide Kikkawa, Toshiya Senda, Yoshiaki Isobe, Umeharu Ohto, Toshiyuki Shimizu (2020) Structural analysis reveals TLR10 dynamics underlying antagonism nature communications. 11 DOI:doi:10.1038/s41467-020-19025-z

Tomoki Himiyama, Yuko Tsuchiya, Yasushige Yonezawa and Tsutomu Nakamura (2020) Rebuilding ring-type assembly of peroxiredoxin by chemical modification The Royal Society of Chemistry.

Dianita S. Saputri, Songling Li, Floris J. van Eerden, John Rozewicki, Zichang Xu, Hendra S. Ismanto, Ana Davila, Shunsuke Teraguchi, Kazutaka Katoh and Daron M. Standley (2020) Flexible, Functional, and Familiar: Characteristics of SARS-CoV-2 Spike Protein Evolution Frontiers in Microbiology. 11 DOI:doi: 10.3389/fmicb.2020.02112

Kazuki Akisawa, Ryo Hatada, Koji Okuwaki, Yuji Mochizuki, Kaori Fukuzawa, Yuto Komeiji, Shigenori Tanaka (2020) Interaction analyses on SARS-CoV-2 spike protein based on large-scale correlated fragment molecular orbital calculations Journal of chemical information and modeling. DOI:doi:10.1021/acs.jcim.0c00283

Yoshio Okiyama,* Tatsuya Nakano, Chiduru Watanabe, Kaori Fukuzawa, Yuto Komeiji, Katsunori Segawa, and Yuji Mochizuki (2020) Acceleration of environmental electrostatic potential using Cholesky decomposition with adaptive metric (CDAM) for fragment molecular orbital (FMO) method Bulletin of the Chemical Society of Japan. DOI:doi:10.1246/bcsj.20200227

MasaoInoue, TomohikoHayashi, SimonHikiri, MitsunoriIkeguchi, MasahiroKinoshita (2020) Comparison based on statistical thermodynamics between globule-to-coil transition of poly(N-isopropylacrylamide) and cold denaturation of a protein Journal of Molecular Liquids. DOI:doi:10.1016/j.molliq.2020.114129

Ryunosuke Yoshino, Nobuaki Yasuo, Masakazu Sekijima (2020) Identifcation of key interactions betweenSARS_CoV_2 main protease andinhibitor drug candidate Scientific Reports. 10 DOI:doi:10.1038/s41598-020-69337-9

Hidetoshi Kono, Hisashi Ishida (2020) Nucleosome unwrapping and unstacking Current Opinion in Structural Biology. 64 119-125 DOI:doi: 10.1016/j.sbi.2020.06.020

Yuko Tsuchiya, Kentaro Tomii (2020) Structural Modeling and Ligand-Binding Prediction for Analysis of Structure-Unknown and Function-Unknown Proteins Using FORTE Alignment and PoSSuM Pocket Search Methods in molecular biology. DOI:doi: 10.1007/978-1-0716-0708-4_1

Hikaru Tsuchiya, Akinori Endo, Yasushi Saeki (2020) Multi-Step Ubiquitin Decoding Mechanism for Proteasomal Degradatio Pharmaceuticals. 13 :6, e128- DOI:doi: 10.3390/ph13060128

Chikako Ono, Takasuke Fukuhara, Songling Li, Jian Wang, Asuka Sato, Takuma Izumi, Yuzy Fauzyah, Takuya Yamamoto, Yuhei Morioka, Nikolay V Dokholyan, Daron M Standley, Yoshiharu Matsuura (2020) Various miRNAs Compensate the Role of miR-122 on HCV Replication PLOS Pathogens. 16 :6, e1008308- DOI:doi: 10.1371/journal.ppat.1008308

Koichiro Kato, Tomohide Masuda, Chiduru Watanabe, Naoki Miyagawa, Hideo Mizouchi, Shumpei Nagase, Kikuko Kamisaka, Kanji Oshima, Satoshi Ono, Hiroshi Ueda, Atsushi Tokuhisa, Ryo Kanada, Masateru Ohta, Mitsunori Ikeguchi, Yasushi Okuno, Kaori Fukuzawa, Teruki Honma (2020) High-precision Atomic Charge Prediction for Protein Systems Using Fragment Molecular Orbital Calculation and Machine Learning Journal of Chemical Information and Modeling . DOI:doi: 10.1021/acs.jcim.0c00273

Koichiro Kato, Teruki Honma, Kaori Fukuzawa (2020) Intermolecular Interaction Among Remdesivir, RNA and RNA-Dependent RNA Polymerase of SARS-CoV-2 Analyzed by Fragment Molecular Orbital Calculation ChemRxiv.

Satomi Kori, Tomohiro Jimenji, Toru Ekimoto, Miwa Sato, Fumie Kusano, Takashi Oda, Motoko Unoki, Mitsunori Ikeguchi, Kyohei Arita (2020) Serine 298 Phosphorylation in Linker 2 of UHRF1 Regulates Ligand-Binding Property of Its Tandem Tudor Domain Journal of Molecular Biology. DOI:doi: 10.1016/j.jmb.2020.05.006

Sayaka Takehara, Shun Sakuraba, Bunzo Mikami, Hideki Yoshida, Hisako Yoshimura, Aya Itoh,Masaki Endo, Nobuhisa Watanabe, Takayuki Nagae, Makoto Matsuoka & Miyako Ueguchi-Tanaka (2020) A common allosteric mechanism regulates homeostatic inactivation of auxin and gibberellin Nature Communications. 11 :1, DOI:doi: 10.1038/s41467-020-16068-0

DaisukeTakaya, HideakiNiwa, JunkoMikuni, KanaNakamura, NorikoHanda, AkikoTanaka, ShigeyukiYokoyama, TerukiHonma (2020) Protein ligand interaction analysis against new CaMKK2 inhibitors by use of X-ray crystallography and the fragment molecular orbital (FMO) method Journal of Molecular Graphics and Modelling. 99 DOI:doi: 10.1016/j.jmgm.2020.107599

Atsushi Matsumoto, Masaaki Sugiyama, Zhenhai Li, Anne Martel, Lionel Porcar, Rintaro Inoue, Daiki Kato, Akihisa Osakabe, Hitoshi Kurumizaka, Hidetoshi Kono (2020) Structural Studies of Overlapping Dinucleosomes in Solution Biophysical Journal. 118 DOI:doi: 10.1016/j.bpj.2019.12.010

Yuko Tsuchiya, Kentaro Tomii (2020) Neural networks for protein structure and function prediction and dynamic analysis Biophysical Reviews. DOI:doi: 10.1007/s12551-020-00685-6

Hiroyuki Fukuda & Kentaro Tomii_ (2020) DeepECA: an end-to-end learning framework for protein contact prediction from a multiple sequence alignment BMC Bioinformatics. 21 10- DOI:doi: 10.1186/s12859-019-3190-x

Kiyoharu Fukushima, Takashi Satoh, Fuminori Sugihara, Yuki Sato, Toru Okamoto, Yuichi Mitsui, Sachiyo Yoshio, Songling Li, Satoshi Nojima, Daisuke Motooka, Shota Nakamura, Hiroshi Kida, Daron M. Standley, Eiichi Morii, Tatsuya Kanto, Motoko Yanagita, Yoshiharu Matsuura, Takashi Nagasawa, Atsushi Kumanogoh, Shizuo Akira (2020) Dysregulated Expression of the Nuclear Exosome Targeting Complex Component Rbm7 in Nonhematopoietic Cells Licenses the Development of Fibrosis. Immunity. 52 :3, 542-556 DOI: doi: 10.1016/j.immuni.2020.02.007.

Hozaifa Metwally, Toshio Tanaka, Songling Li, Gyanu Parajuli, Sujin Kang, Hamza Hanieh, Shigeru Hashimoto, Jaya P. Chalise, Yohannes Gemechu, Daron M. Standley, and Tadamitsu Kishimoto (2020) Noncanonical STAT1 phosphorylation expands its transcriptional activity into promoting LPS-induced IL-6 and IL-12p40 production. Science Signaling. 13 :624, DOI:doi:10.1126/scisignal.aay0574.

Afifa Ayu Koesoema, Daron M. Standley, Toshiya Senda & Tomoko Matsuda (2020) Impact and relevance of alcohol dehydrogenase enantioselectivities on biotechnological applications Applied Micribiology and Biotechnology. 104 2897-2909 DOI:doi: 10.1007/s00253-020-10440-2

Afifa Ayu Koesoema, Daron M. Standley, Shusuke Ohshima, Mayumi Tamura, Tomoko Matsuda (2020) Control of enantioselectivity in the enzymatic reduction of halogenated acetophenone analogs by substituent positions and sizes Tetrahedron Letters. DOI:doi: 10.1016/j.tetlet.2020.151820

Shu Tadaka, Eiji Hishinuma, Shohei Komaki, Ikuko N Motoike, Junko Kawashima, Daisuke Saigusa, Jin Inoue, Jun Takayama, Yasunobu Okamura, Yuichi Aoki, Matsuyuki Shirota, Akihito Otsuki, Fumiki Katsuoka, Atsushi Shimizu, Gen Tamiya, Seizo Koshiba, Makoto Sasaki, Masayuki Yamamoto, Kengo Kinoshita (2020) jMorp updates in 2020: large enhancement of multi-omics data resources on the general Japanese population DOI:10.1093/nar/gkaa1034

Kouta Mayanagi, Keisuke Oki, Naoyuki Miyazaki, Sonoko Ishino, Takeshi Yamagami, Kosuke Morikawa, Kenji Iwasaki, Daisuke Kohda, Tsuyoshi Shirai, Yoshizumi Ishino (2020) Two conformations of DNA polymerase D-PCNA-DNA, an archaeal replisome complex, revealed by cryo-electron microscopy BMC Biology. DOI:10.1186/s12915-020-00889-y

Mayu Shibata, b, Kohji Okamura, Kei Yura, Akihiro Umezawa (2020) High-precision multiclass cell classification by supervised machine learning on lectin microarray data Regenerative Therapy. 15 195-201 DOI:10.1016/j.reth.2020.09.005

Kanako Ishizuka, Tomoyuki Yoshida, Takeshi Kawabata, Ayako Imai, Hisashi Mori, Hiroki Kimura, Toshiya Inada, Yuko Okahisa, Jun Egawa, Masahide Usami, Itaru Kushima, Mako Morikawa, Takashi Okada, Masashi Ikeda, Aleksic Branko, Daisuke Mori, Toshiyuki Someya, Nakao Iwata & Norio Ozaki (2020) Functional characterization of rare NRXN1 variants identified in autism spectrum disorders and schizophrenia Journal of Neurodevelopmental Disorders. DOI:10.1186/s11689-020-09325-2

Kuribayashi W, Oshima M, Itokawa N, Koide S, Nakajima-Takagi Y, Yamashita M, Yamazaki S, Rahmutulla B, Miura F, Ito T, Kaneda A, Iwama A. (2021) Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche Journal of Experimental Medicine. 218 :3, e20192283- DOI:10.1084/jem.20192283 PMID:33231616

Sangatsuda Y, Miura F, Araki H, Mizoguchi M, Hata N, Kuga D, Hatae R, Akagi Y, Amemiya T, Fujioka Y, Arai Y, Yoshida A, Shibata T, Yoshimoto K, Iihara K, Ito T. (2020) Base-resolution methylomes of gliomas bearing histone H3.3 mutations reveal a G34 mutant-specific signature shared with bone tumors. Scientific Reports. 10 :1, 16162- DOI:10.1038/s41598-020-73116-x PMID:32999376

Kenjiro Shirane, Fumihito Miura, Takashi Ito, Matthew C Lorincz (2020) NSD1-deposited H3K36me2 directs de novo methylation in the mouse male germline and counteracts Polycomb-associated silencing Nature Genetics. 52 :10, 1088-1098 DOI:10.1038/s41588-020-0689-z PMID:32929285

Shinya Tanaka, Wataru Ise, Takeshi Inoue, Ayako Ito, Chisato Ono, Yoshihito Shima, Shuhei Sakakibara, Manabu Nakayama, Kentaro Fujii, Ikuo M, Jafar Sharif, Haruhiko Koseki, Pandelakis A Koni, Indu Raman, Quan-Zhen Li, Masato Kubo, Katsunori Fujiki, Ryuichiro Nakato, Katsuhiko Shirahige, Hiromitsu Araki, Fumihito Miura, Takashi Ito, Eiryo Kawakami, Yoshihiro Baba, Tomohiro Kurosaki (2020) Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity Nature Immunology. 21 :8, 950-961 DOI:10.1038/s41590-020-0700-y PMID:32572241

Keisuke Yoshida, Toshio Maekawa, Nhung Hong Ly, Shin-Ichiro Fujita, Masafumi Muratani, Minami Ando, Yuki Katou, Hiromitsu Araki, Fumihito Miura, Katsuhiko Shirahige, Mariko Okada, Takashi Ito, Bruno Chatton, Shunsuke Ishii (2020) ATF7-Dependent Epigenetic Changes Are Required for the Intergenerational Effect of a Paternal Low-Protein Diet Molecular Cell. 78 :3, 445-458 DOI:10.1016/j.molcel.2020.02.028 PMID:32197065

Masashi Tsubaki, Kentaro Tomii, Jun Sese (2020) Compound–protein interaction prediction with end-to-end learning of neural networks for graphs and sequences bioinfomatics. 35 :2, 309-318 DOI:10.1093/bioinformatics/bty535

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