成果

創薬等先端技術支援基盤プラットフォーム(BINDS)の実施者による研究支援と研究高度化の成果として輩出されたデータベース、 ツール、論文および特許を紹介します。

開発されたデータベースやツール

ケミカルシーズ・リード 探索ユニット

インシリコユニット

プラットフォーム機能最適化ユニット

BINDS支援技術に関する研究成果(論文)

Murayama T, Ogawa H, Kurebayashi N, Ohno S, Horie M, Sakurai T (2018)  A tryptophan residue in the caffeine-binding site of the ryanodine receptor regulates Ca2+ sensitivity Communications Biology. 1 98- DOI:10.1038/s42003-018-0103-x
Murayama, T, Kurebayashi N, Ikegami-Yuasa M, Mori S, Suzuki Y, Akima R, Ogawa H, Suzuki J, Kanemaru K, Oyamada H, Kiuchi Y, Iino M, Kagechika H, Sakurai T (2018)  Efficient high-throughput screening by ER Ca2+ measurement to identify inhibitors of ryanodine receptor Ca2+-release channels. Molecular Pharmacology. 94 722-730 DOI:10.1124/mol.117.111468 PMID:29674523 
Hijikata A, Tsuji T, Shionyu M, Shirai T (2017)  Decoding disease-causing mechanisms of missense mutations from supramolecular structures. Scientific Reports. :7,  8541- DOI:DOI:10.1038/s41598-017-08902-1 PMID:28819267 
Nagao Y., Hisanaga T., Utsumi T., Egami H., Kawato Y., Hamashima Y.  (2018)  Enantioselective Synthesis of Nelfinavir via Asymmetric Bromocyclization of Bisallylic Amide The Journal of Organic Chemistry. DOI:10.1021/acs.joc.8b00039.
Egami H., Niwa T., Sato H., Hotta R., Rouno T., Kawato Y., Hamashima Y. (2018)  Dianionic Phase-Transfer Catalyst for Asymmetric Fluoro-cyclization Journal of the American Chemical Society. :140,  2785-2788 DOI:1-.1021/jacs.7b13690
Egami H., Masuda S., Kawato Y., Hamashima Y. (2018)  Photofluorination of Aliphatic C–H Bonds Promoted by the Phthalimide Group Organic Letters. :20,  1367-1370 DOI:10.1021/acs.orglett.8b00133
Konishi H, Tanaka H, Manabe K.  (2017)  Pd-Catalyzed Selective Synthesis of Cyclic Sulfonamides and Sulfinamides Using K2S2O5 as a Sulfur Dioxide Surrogate Organic Letters. 19 1578-1581 DOI:10.1021/acs.orglett.7b00402
SHIBUYA M, OKAMOTO M, FUJITA S, ABE M, YAMAMOTO Y (2018)  Boron-Catalyzed Double Hydrofunctionalization Reactions of Unactivated Alkynes ACS Catalysis. 8 4189-4193 DOI:10.1021/acscatal.8b00955

BINDSの支援を受けた研究成果(論文)

Obayashi T, Kagaya Y, Aoki Y, Tadaka S, Kinoshita K (2018)  COXPRESdb v7: a gene coexpression database for 11 animal species supported by 23 coexpression platforms for technical evaluation and evolutionary inference. Nucleic acids research. 47 :D1,  D55-D62 DOI:doi: 0.1093/nar/gky1155
Kazunori D. Yamada & Kengo Kinoshita  (2018)  De novo profile generation based on sequence context specificity with the long short-term memory network. BMC bioinformatics . 19 :272,  DOI:doi: 10.1186/s12859-018-2284-1
Shohei Nosaki, Takuya Miyakawa, Yuqun Xu, Akira Nakamura, Kei Hirabayashi, Tadao Asami, Takeshi Nakano & Masaru Tanokura  (2018)  Structural basis for brassinosteroid response by BIL1/BZR1 Nature Plants. 4 771-776 DOI:doi:10.1038/s41477-018-0255-1
Atsushi Yamagata, Yuri Miyazaki, Norihiko Yokoi, Hideki Shigematsu, Yusuke Sato, Sakurako Goto-Ito, Asami Maeda, Teppei Goto, Makoto Sanbo, Masumi Hirabayashi, Mikako Shirouzu, Yuko Fukata, Masaki Fukata & Shuya Fukai  (2018)  Structural basis of epilepsy-related ligand–receptor complex LGI1–ADAM22 Nat. commun.. 9 DOI:https://doi.org/10.1038/s41467-018-03947-w
HupingWang, WenyuHan, JunichiTakagi, YaoCon (2018)  Yeast Inner-Subunit PA–NZ-1 Labeling Strategy for Accurate Subunit Identification in a Macromolecular Complex through Cryo-EM Analysis Journal of molecular biology . 430 :10,  1417-1425 DOI:doi: /10.1016/j.jmb.2018.03.026
SanaeTabata, YuKitago, YukiFujii, EmikoMihara, KeikoTamura-Kawakami, NaokoNorioka, KatsuTakahashi, Mika K.Kaneko, YukinariKato, JunichiTakagi (2018)  An anti-peptide monoclonal antibody recognizing the tobacco etch virus protease-cleavage sequence and its application to a tandem tagging system Science Direct. 147 94-99 DOI:doi: 10.1016/j.pep.2018.03.004.
Masamichi Nagae, Yasuhiko Kizuka, Emiko Mihara, Yu Kitago, Shinya Hanashima, Yukishige Ito, Junichi Takagi, Naoyuki Taniguchi & Yoshiki Yamaguchi (2018)  Structure and mechanism of cancer-associated N-acetylglucosaminyltransferase-V nature communications. 9 DOI:https://doi.org/10.1038/s41467-018-05931-w
Kubo T, Hou Y, Cochran DA, Witman GB, Oda T (2018)  A microtubule-dynein tethering complex regulates the axonemal inner dynein f (I1) Mol Biol Cell. . 29 1060-1074 DOI:https://doi.org/10.1091/mbc.E17-11-0689
Hiroshi Yamaguchi, Toshiyuki Oda, Masahide Kikkawa , Hiroyuki Takeda  (2018)  Systematic studies of all PIH proteins in zebrafish reveal their distinct roles in axonemal dynein assembly e Life. 7 DOI:DOI: 10.7554/eLife.36979
Emiri Hiramoto, Akihisa Tsutsumi, Risa Suzuki, Shigeru Matsuoka, Satoko Arai, Masahide Kikkawa and Toru Miyazaki (2018)  The IgM pentamer is an asymmetric pentagon with an open groove that binds the AIM protein Sci adv. 4 DOI:DOI: 10.1126/sciadv.aau1199
Go Kasuya, Takanori Nakane, Takeshi Yokoyama, Yanyan Jia, Masato Inoue, Kengo Watanabe, Ryoki Nakamura, Tomohiro Nishizawa, Tsukasa Kusakizako, Akihisa Tsutsumi, Haruaki Yanagisawa, Naoshi Dohmae, Motoyuki Hattori, Hidenori Ichijo, Zhiqiang Yan, Masahide Kikkawa, Mikako Shirouzu, Ryuichiro Ishitani & Osamu Nureki  (2018)  Cryo-EM structures of the human volume-regulated anion channel LRRC8 Nat Struct Mol Biol. 25 797-804 DOI:doi: 10.1038/s41594-018-0109-6
Noritoshi Shamoto, Keishi Narita, Tomohiro Kubo, Toshiyuki Oda, and Sen Takeda (2018)  CFAP70 Is a Novel Axoneme-Binding Protein That Localizes at the Base of the Outer Dynein Arm and Regulates Ciliary Motility cells. 7 :9,  DOI:doi: 10.3390/cells7090124
Hidetsugu Asada, Shoichiro Horita, Kunio Hirata, Mitsunori Shiroishi, Yuki Shiimura, Hiroko Iwanari, Takao Hamakubo, Tatsuro Shimamura, Norimichi Nomura, Osamu Kusano-Arai, Tomoko Uemura, Chiyo Suno, Takuya Kobayashi & So Iwata  (2018)  Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog Nature Structural & Molecular Biology. 25 570-576 DOI:https://doi.org/10.1038/s41594-018-0079-8
Yosuke Toyoda, Kazushi Morimoto, […]Takuya Kobayashi  (2018)  Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface Nature Chemical Biology . 15 18-26 DOI:doi: 10.1038/s41589-018-0131-3
Yohei Katsuyama, Yukari Sato, Yoshinori Sugai, Yousuke Higashiyama, Miki Senda,Toshiya Senda and Yasuo Ohnishi (2018)  Crystal structure of the nitrosuccinate lyase CreD incomplex with fumarate provides insights into the catalyticmechanism for nitrous acid elimination The FEBS Journal. 285 :8,  1540-1555 DOI:doi:10.1111/febs.14429
Eriko Sumi, Takashi Nomura, Ryuta Asada, Ryuji Uozumi, Harue Tada, Yoko Amino, Teruo Sawada, Atsushi Yonezawa, Masatoshi Hagiwara & Kenji Kabashima  (2018)  Safety and Plasma Concentrations of a Cyclin-dependent Kinase 9 (CDK9) Inhibitor, FIT039, Administered by a Single Adhesive Skin Patch Applied on Normal Skin and Cutaneous Warts Clinical Drug Investigation . 39 55-61 DOI:https://doi.org/10.1007/s40261-018-0712-7
Takashi Nakaoku, Takashi Kohno, Mitsugu Araki, Seiji Niho, Rakhee Chauhan, Phillip P. Knowles,Katsuya Tsuchihara, Shingo Matsumoto, Yoko Shimada , Sachiyo Mimaki, Genichiro Ishii,Hitoshi Ichikawa, Satoru Nagatoishi, Kouhei Tsumoto, Yasushi Okuno, Kiyotaka Yoh,Neil Q. McDonald6,9 & Koichi Goto (2018)  A secondary RET mutation in the activation loop conferring resistance to vandetanib Nat. commun.. 9 DOI:doi: 10.1038/s41467-018-02994-7
Naoko Obi Tetsuya Fukuda Noboru Nakayama John Ervin Yasuhiko Bando Toshihide Nishimura Satoru Nagatoishi Kouhei Tsumoto Takeshi Kawamura (2018)  Development of drug discovery screening system by molecular interaction kinetics–mass spectrometry Rapid Commun Mass Spectrom. 32 665-671 DOI: doi: 10.1002/rcm.8083
Shinya Tashiro, Jose M. M. Caaveiro, Makoto Nakakido, Aki Tanabe, Satoru Nagatoishi, Yasushi Tamura, Noriyuki Matsuda, Dali Liu, Quyen Q. Hoang, Kouhei Tsumoto (2018)  Discovery and Optimization of Inhibitors of the Parkinson’s Disease Associated Protein DJ-1 ACS Chem. Biol.. 13 :9,  2783-2793 DOI:https://doi.org/10.1021/acschembio.8b00701
SatoruNagatoishi, SouYamaguchi, EtsukoKatoh, KeitaKajita, TakaneYokotagawa, SatoruKanai, ToshioFuruya, KouheiTsumoto (2018)  A combination of 19F NMR and surface plasmon resonance for site-specific hit selection and validation of fragment molecules that bind to the ATP-binding site of a kinase Bioorg. Med. Chem.. 26 :8,  1929-1938 DOI:https://doi.org/10.1016/j.bmc.2018.02.041
DaisukeYasudaAkihiroYuasaRikaObataMaoNakajimaKyokoTakahashiTomoyukiOheYoshinobuIchimuraMasaakiKomatsuMasayukiYamamoto RiyoImamuraHirotatsuKojimaTakayoshiOkabeTetsuoNaganoTadahikoMashino (2018)  Discovery of benzo[g]indoles as a novel class of non-covalent Keap1-Nrf2 protein-protein interaction inhibitor Bioorganic & Medicinal Chemistry Letters. 27 :22,  5006-5009 DOI:https://doi.org/10.1016/j.bmcl.2017.10.008
Mizuho Kajikawa, Toyoyuki Ose, Yuko Fukunaga, Yuki Okabe, Naoki Matsumoto, Kento Yonezawa, Nobutaka Shimizu, Simon Kollnberger, Masanori Kasahara & Katsumi Maenaka  (2018)  Structure of MHC class I-like MILL2 reveals heparan-sulfate binding and interdomain flexibility Nat. commun.. 9 DOI:https://doi.org/10.1038/s41467-018-06797-8
Junichi Taniguchi, Yihong Feng, Ganesh N. Pandian, Fumitaka Hashiya, Takuya Hidaka, Kaori Hashiya, Soyoung Park, Toshikazu Bando, Shinji Ito, Hiroshi Sugiyama (2018)  Biomimetic Artificial Epigenetic Code for Targeted Acetylation of Histones J. Am. Chem. Soc. 140 :23,  7108-7115 DOI:doi: 10.1021/jacs.8b01518
Zutao Yu Wei‐Che Hsieh Sefan Asamitsu Kaori Hashiya Dr. Toshikazu Bando Prof. Dr. Danith H. Ly Prof. Dr. Hiroshi Sugiyama (2018)  Orthogonal γPNA Dimerization Domains Empower DNA Binders with Cooperativity and Versatility Mimicking that of Transcription Factor Pairs Chem.Eur.J. 24 :53,  14183-14188 DOI:doi: 10.1002/chem.201801961
長野哲雄編 (2018)  創薬科学―メディシナルケミストへの道 東京化学同人. DOI:ISBN: 9784807909483
NorioSuzuki, YukariMatsuo-Tezuka, YusukeSasaki, KojiSato, KenichiroMiyauchi, KoichiroKato, SakaeSaito, YasushiShimonaka, MichinoriHirata, MasayukiYamamoto (2018)  Iron attenuates erythropoietin production by decreasing hypoxia-inducible transcription factor 2α concentrations in renal interstitial fibroblasts Kidney International. 94 :5,  900-911 DOI:DOI: 10.1016/j.kint.2018.06.028
Kawaguchi SI, Gonda Y, Yamamoto T, Sato Y, Shinohara H, Kobiki Y, Ichimura A, Dan T, Sonoda M, Miyata T, OgawaA, TsujitaT (2018)  Furan- and Thiophene-2-Carbonyl Amino Acid Derivatives Activate Hypoxia-Inducible Factor via Inhibition of Factor Inhibiting Hypoxia-Inducible Factor-1. Molecules. . 23 :4,  DOI:doi: 10.3390/molecules23040885.
Takehiro Nishimura, Junya Kawai,Yoshiteru Oshima, Haruhisa Kikuchi (2018)  Removal of the E-Olefin Barrier of Humulene Leading to Unnatural Terpenoid-like Skeletons Org. Lett. . 20 :22,  7317-7320 DOI:https://doi.org/10.1021/acs.orglett.8b03259
Dr. Haruhisa Kikuchi Kosuke Kawai Yota Nakashiro Takayuki Yonezawa Kumi Kawaji Prof. Dr. Eiichi. N. Kodama Prof. Dr. Yoshiteru Oshima (2018)  Construction of a Meroterpenoid‐Like Compounds Library Based on Diversity‐Enhanced Extracts Chem. Eur. J.. 25 :4,  1106-1112 DOI:doi: 10.1002/chem.201805417
Haruhisa Kikuchi and Yoshiteru Oshima (2018)  Developments toward the Production of Diverse Natural-Product-Like Compounds: Diversity-Oriented Synthesis and Diversity-Enhanced Extracts Heterocycles. 96 :9,  1509-1527 DOI:doi: 10.3987/REV-18-885
Rehana Parvin, Erika Noro, Akiko Saito-Hakoda, Hiroki Shimada, Susumu Suzuki, Kyoko Shimizu, Hiroyuki Miyachi, Atsushi Yokoyama, and Akira Sugawara (2018)  Inhibitory Effects of a Novel PPAR-γ Agonist MEKT1 on Pomc Expression/ACTH Secretion in AtT20 Cells PPAR Res.. 2018 DOI:doi: 10.1155/2018/5346272
Erika Noro ,Atsushi Yokoyama ,Makoto Kobayashi ,Hiroki Shimada ,Susumu Suzuki ,Mari Hosokawa ,Tomohiro Takehara ,Rehana Parvin ,Hiroki Shima,Kazuhiko Igarashi andAkira Sugawara (2018)  Endogenous Purification of NR4A2 (Nurr1) Identified Poly(ADP-Ribose) Polymerase 1 as a Prime Coregulator in Human Adrenocortical H295R Cells. Int J Mol Sci.. 19 :5,  DOI:doi: 10.3390/ijms19051406
Hirokazu Tsukamoto, Yumi Nomura, and Takayuki Doi (2018)  First Total Synthesis of Palmarumycin C6 Based on Double Oxa-Michael Addition of 1,8-Dihydroxynaphthalene to 3-Bromo-1-indenone heterocycles. 99 549-565 DOI:doi: 10.3987/COM-18-S(F)52
Hiromichi Egami*Shuya MasudaYuji KawatoYoshitaka Hamashima (2018)  Photofluorination of Aliphatic C–H Bonds Promoted by the Phthalimide Group Org. Lett.. 20 :5,  1367-1370 DOI:https://doi.org/10.1021/acs.orglett.8b00133
Egami H., Niwa T., Sato H., Hotta R., Rouno T., Kawato Y., Hamashima Y. (2018)  Dianionic Phase-Transfer Catalyst for Asymmetric Fluoro-cyclization J. Am. Chem. Soc.. 140 :8,  2785-2788 DOI:https://doi.org/10.1021/jacs.7b13690
Yoshihiro NagaoTatsunari HisanagaTakahiro UtsumiHiromichi EgamiYuji KawatoYoshitaka Hamashima (2018)  Enantioselective Synthesis of Nelfinavir via Asymmetric Bromocyclization of Bisallylic Amide J. Org. Chem. 83 :13,  7290-7295 DOI:https://doi.org/10.1021/acs.joc.8b00039
Masamichi Ito, Hironori Hara, Norifumi Takeda, Atsuhiko T. Naito, SeitaroNomura, Masaki Kondo, YutakaHata, MasanobuUchiyama, Hiroyuki Morita, Issei Komuro (2019)  Characterization of a small molecule that promotes cell cycle activation of human induced pluripotent stem cell-derived cardiomyocytes Journal of Molecular and Cellular Cardiology. 128 90-95 DOI:https://doi.org/10.1016/j.yjmcc.2019.01.020
Tomohiro Sato,Hitomi Yuki,Keiji Ogura,Teruki Honma  (2018)  Construction of an integrated database for hERG blocking small molecules PLOS ONE. 13 :7,  e0199348- DOI:https://doi.org/10.1371/journal.pone.0199348
Toru Sengoku, Takehiro Suzuki, Naoshi Dohmae, Chiduru Watanabe, Teruki Honma, Yasushi Hikida, Yoshiki Yamaguchi, Hideyuki Takahashi, Shigeyuki Yokoyama & Tatsuo Yanagisawa  (2018)  Structural basis of protein arginine rhamnosylation by glycosyltransferase EarP Nature Chemical Biology . 14 368-374 DOI:doi: 10.1038/s41589-018-0002-y
DaisukeTakaya, KojiInaka, AkifumiOmura, KenjiTakenuki, MasashiKawanishi, YukakoYabuki, YukariNakagawa, KeikoTsuganezawa, NaokoOgawa, ChiduruWatanabe, TerukiHonma, KosukeAritake, YoshihiroUrade, MikakoShirouzu, AkikoTanaka (2018)  Characterization of crystal water molecules in a high-affinity inhibitor and hematopoietic prostaglandin D synthase complex by interaction energy studies Bioorganic & Medicinal Chemistry. 26 :16,  4726-4734 DOI:https://doi.org/10.1016/j.bmc.2018.08.014
Motoshi Kamiya and Yuji Sugita (2018)  Flexible selection of the solute region in replica exchange with solute tempering: Application to protein-folding simulations J. Chem. Phys.. 149 :7,  DOI:doi: 10.1063/1.5016222
Kei Moritsugu, Tohru Terada, Hironori Kokubo, Satoshi Endo, Toshimasa Tanaka, and Akinori Kidera (2018)  Multiscale enhanced sampling of glucokinase: Regulation of the enzymatic reaction via a large scale domain motion J. Chem. Phys.. 149 DOI:doi: 10.1063/1.5027444
Atsushi Yamagata, Sakurako Goto-Ito, Yusuke Sato, Tomoko Shiroshima, Asami Maeda, Masahiko Watanabe, Takashi Saitoh, Katsumi Maenaka, Tohru Terada, Tomoyuki Yoshida, Takeshi Uemura & Shuya Fukai  (2018)  Structural insights into modulation and selectivity of transsynaptic neurexin–LRRTM interaction Nat. commun.. 9 DOI:doi: 10.1038/s41467-018-06333-8
Kumar Nagarathinam, Yoshiko Nakada-Nakura, Christoph Parthier, Tohru Terada, Narinobu Juge, Frank Jaenecke, Kehong Liu, Yunhon Hotta, Takaaki Miyaji, Hiroshi Omote, So Iwata, Norimichi Nomura, Milton T. Stubbs & Mikio Tanabe  (2018)  Outward open conformation of a Major Facilitator Superfamily multidrug/H+ antiporter provides insights into switching mechanism Nat. commun.. :9,  DOI:https://doi.org/10.1038/s41467-018-06306-x
Hiroaki Taniguchi, Akihiro Fujimoto, Hidetoshi Kono, Mayuko Furuta, Masashi Fujita and Hidewaki Nakagawa (2018)  Loss-of-function mutations in Zn-finger DNA-binding domain of HNF4A cause aberrant transcriptional regulation in liver cancer. Oncotarget.. 9 :40,  26144-26156 DOI:Oncotarget. 2018 May 25;9(40):26144-26156. doi: 10.18632/oncotarget.25456
Yu Nakashima, Takaaki Mitsuhashi, Yudai Matsuda, Miki Senda, Hajime Sato, Mami Yamazaki, Masanobu Uchiyama, Toshiya Senda, Ikuro Abe (2018)  Structural and Computational Bases for Dramatic Skeletal Rearrangement in Anditomin Biosynthesis J. Am. Chem. Soc.. 140 :30,  9743-9750
Dominique Ray-Gallet, M. Daniel Ricketts, Yukari Sato, Kushol Gupta, Ekaterina Boyarchuk, Toshiya Senda, Ronen Marmorstein & Geneviève Almouzni  (2018)  Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit Nat. commun.. 9 DOI:doi: 10.1038/s41467-018-05581-y
Akiko Higuchi, Naoki Nonaka and Kei Yura (2018)  iMusta4SLC: Database for the structural property and variations of solute carrier transporters Biophysics and Physicobiology. :15,  94-103 DOI:doi: 10.2142/biophysico.15.0_94
Chiaki Ohtaka-Maruyama, Mayumi Okamoto, Kentaro Endo, Minori Oshima, Noe Kaneko, Kei Yura, Haruo Okado, Takaki Miyata, Nobuaki Maeda (2018)  Synaptic transmission from subplate neurons controls radial migration of neocortical neurons Science . 6386 :360,  313-317 DOI:DOI: 10.1126/science.aar2866
Takahiro Segawa, Satoshi Fukuchi , Dylan Bodington , Sayaka Tsutida, Pierre Philippe Mbehang Nguema , Hiroshi Mori and Kazunari Ushida (2019)  Genomic Analyses of Bifidobacterium moukalabense Reveal Adaptations to Frugivore/Folivore Feeding Behavior Microorganisms. 7 :4,  99-112 DOI:https://doi.org/10.3390/microorganisms7040099
NaoyaMatsunaga, YuyaYoshida, NaokiKitajou, AkiraShiraishi, NaokiKusunose, SatoruKoyanagi, ShigehiroOhdo (2019)  Microcurrent stimulation activates the circadian machinery in mice Biochemical and Biophysical Research Communications. 513 :2,  293-299 DOI:https://doi.org/10.1016/j.bbrc.2019.02.022
Atsushi Matsumoto (2019)  Dynamic analysis of ribosome by a movie made from many three-dimensional electron-microscopy density maps Biophysics and Physicobiology. 16 108-113 DOI: https://doi.org/10.2142/biophysico.16.0_108
Kohei Yoshitani Yohei Hizukuri Yoshinori Akiyama (2019)  An in vivo protease activity assay for investigating the functions of the Escherichia coli membrane protease HtpX FEBS Letters. 593 :8,  842-851 DOI: https://doi.org/10.1002/1873-3468.13368
Tomoya Nakagita, Akiko Ishida, Takumi Matsuya, Takuya Kobayashi, Masataka Narukawa, Takatsugu Hirokawa, Makoto Hashimoto, Takumi Misaka (2019)  Structural insights into the differences among lactisole derivatives in inhibitory mechanisms against the human sweet taste receptor PLOS ONE. 14 :3,  DOI:https://doi.org/10.1371/journal.pone.0213552
Suguru Yoshida, Tomoko Kuribara, Harumi Ito, Tomohiro Meguro, Yoshitake Nishiyama, Fumika Karaki, Yasutomo Hatakeyama, Yuka Koike, Isao Kii and Takamitsu Hosoya (2019)  A facile preparation of functional cycloalkynes via an azide-to-cycloalkyne switching approach Royal Society of Chemistry. 55 3556-3559 DOI:0.1039/C9CC01113G
Akane Fujii, Osamu Nakagawa, Yuki Kishimoto, Takumi Okuda, Yusuke Nakatsuji , Natsumi Nozaki, Yuuya Kasahara, Satoshi Obika (2019)  1,3,9‐Triaza‐2‐oxophenoxazine artificial nucleobase forms highly stable self‐base pairs with three AgI ions in a duplex Chemistry a Eouropean journal. 25 :31,  7443-7448 DOI:Chemistry a Eouropean journal
Satoshi Yamasaki, Takayuki Amemiya, Yukimitsu Yabuki, Katsuhisa Horimoto, Kazuhiko Fukui (2019)  ToGo-WF: prediction of RNA tertiary structures and RNA–RNA/protein interactions using the KNIME workflow Journal of Computer-Aided Molecular Design. 33 :5,  497-507 DOI:doi.org/10.1007/s10822-019-00195-y
HiroakiIto, TakeshiSugawara, SoyaShinkai, SatoshiMizukawa, AyakaKondo, HisamichiSenda, KengoSawai, KokiIto, SayakaSuzuki, MasakatsuTakaine, SatoshiYoshida, HiromiImamura, KenjiKitamura, ToshinoriNamba, Shin-ichiTate, MasaruUeno (2019)  Spindle pole body movement is affected by glucose and ammonium chloride in fission yeast Biochemical and Biophysical Research Communications. 511 :4,  820-825 DOI:https://doi.org/10.1016/j.bbrc.2019.02.128
Atsunori Oshima (2019)  Potential of cryo-EM for high-resolution structural analysis of gap junction channels Current Opinion in Structural Biology. 54 78-85 DOI:https://doi.org/10.1016/j.sbi.2019.01.005
KazukiYamamoto, AkiraKatsuyama, SatoshiIchikawa (2019)  Structural requirement of tunicamycin V for MraY inhibition Bioorganic & Medicinal Chemistry. 27 :8,  1717-1719 DOI:https://doi.org/10.1016/j.bmc.2019.02.035
Kengo Kitadokoro Mizuki Kakara Shingo Matsui Ryouhei Osokoshi Uschara Thumarat Fusako Kawai Shigeki Kamitani (2019)  Structural insights into the unique polylactate‐degrading mechanism of Thermobifida alba cutinase The FEBS Journal. 286 :11,  2087-2098 DOI:https://doi.org/10.1111/febs.14781
Hiroshi Nonaka, Yuki Nakanishi, Satoshi Kuno, Tomoki Ota, Kentaro Mochidome, Yutaro Saito, Fuminori Sugihara, Yoichi Takakusagi, Ichio Aoki, Satoru Nagatoishi, Kouhei Tsumoto, and Shinsuke Sando (2019)  Design strategy for serine hydroxymethyltransferase probes based on retro-aldol-type reaction nature communications. 10 :876,  DOI:10.1038/s41467-019-08833-7 PMID:30787298 
Aya Shiba-Ishii, Jeongmin Hong, Takatsugu Hirokawa, Yunjung Kim, Tomoki Nakagawa, Shingo Sakashita, Noriaki Sakamoto, Yukinori Kozuma, Yukio Sato and Masayuki Noguchi (2019)  Stratifin inhibits SCFFBW7 formation and blocks ubiquitination of oncoproteins during the course of lung adenocarcinogenesis Clinical Cancer Research. 25 :9,  DOI: 10.1158/1078-0432.CCR-18-3631
KanaOkada, TakaoYamaguchi, KosukeDodo, MikikoSodeoka, SatoshiObika (2019)  Detection of esterase activity by chromogenic and fluorogenic probe based on an O-nitrobenzoxadiazole (O-NBD) unit Bioorganic & Medicinal Chemistry. 27 :7,  1444-1448 DOI:https://doi.org/10.1016/j.bmc.2019.02.036
Nobuaki Yasuo, Yusuke Nakashima, Masakazu Sekijima (2019)  CoDe-DTI: Collaborative Deep Learning-based Drug-Target Interaction Prediction 2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). 792-797 DOI:10.1109/BIBM.2018.8621368
K.Yamanishi, Y. Sin, S. Terawaki, Y. Higuchi and N. Shibata (2019)  High-resolution structure of a Y27W mutant of the Dishevelled2 DIX domain Acta Crystallographica Section F. F75 116-122 DOI:https://doi.org/10.1107/S2053230X18018290
Risako Tamura Rika Oi Satoko Akashi Mika K. Kaneko Yukinari Kato Terukazu Nogi (2019)  Application of the NZ‐1 Fab as a crystallization chaperone for PA tag‐inserted target proteins Prortein Science. 28 :4,  823-836 DOI:10.1002/pro.3580
Seiki Baba, Nobuhiro Mizuno, Hideo Okumura, Nipawan Nuemket, Kazuya Hasegawa, Yuki Nakamura,Hironori Murakami, Go Ueno, Tomoki Fukui, Takaki Irie, Masayuki Tanaka, Hiroshi Yamazaki, Haruhiko Ohashi, Masaki Yamamoto Takashi Kumasaka, (2019)  Upgrade of bending magnet MX beamline BL38B1 at SPring-8 AIP Conference Proceedings. 2054 :1,  DOI:10.1063/1.5084639
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